Hypertension Is Associated With Antibody Response and Breakthrough Infection in Health Care Workers Following Vaccination With Inactivated SARS-CoV-2

Soegiarto, Gatot; Wulandari, Laksmi; Purnomosari, Dewajani; Fahmita, Karin Dhia; Gautama, Hendra Ikhwan; Hadmoko, Satrio Tri; Prasetyo, Muhammad Edwin; Mahdi, Bagus Aulia; Arafah, Nur; Prasetyaningtyas, Dewi; Negoro, Pujo Prawiro; Prakoeswa, Cita Rosita Sigit; Endaryanto, Anang; Suprabawati, Desak Gede Agung; Tinduh, Damayanti; Rachmad, Eka Basuki; Triyono, Erwin Astha; Wahyuhadi, Joni; Keswardiono, Catur Budi; Wardani, Feby Elyana; Mayorita, Fitriyah; Kristiani, Nunuk; Baskoro, Ari; Fetarayani, Deasy; Nurani, Wita Kartika; Oceandy, Delvac

doi:10.2139/ssrn.4008922

“…Due to elevated levels of pro-inflammatory cytokines which correlates with hyporesponsiveness to vaccination [16] and perivascular inflammation [17] in hypertension, there is an impaired immune function, influencing the response to vaccination. The findings correlate with a study conducted in Indonesia by Soegiarto et al [18] in 2021, on 2714 healthcare workers who received two doses of inactivated viral vaccine, showed that hypertension is associated with lower antibody titers and breakthrough infection following COVID-19 vaccination. Similarly in diabetic patients, dysregulation of antigen presentation and deteriorated complement function, followed by hyperglycemia and insulin resistance, could justify lower levels of antibodies in diabetes [15].…”

Section: Discussionsupporting

confidence: 89%

Is Omicron really mild? - Comparative analysis of comorbidities and disease outcomes associated with SARS-CoV-2 Omicron (B.1.1.529) and Delta (B.1.617.2) variants

Mitra

¹

,

Manchanda

²

,

Rafique

³

et al. 2022

Preprint

0

View full text Add to dashboard Cite

Introduction Multiple variants of SARS-CoV-2 from Alpha to Omicron have an estimated 6.1 million deaths globally till date. However, variants have been found to vary in transmissibility and severity. The present study deals with comparison of morbidity and mortality with SARS-CoV-2 Omicron (B.1.1.529) and Delta (B.1.617.2) variants. Methods An observational retrospective cohort study was conducted on a cohort of laboratory confirmed patients of SARS-CoV-2 diagnosed by qRT-PCR of nasopharyngeal swabs in periods; April-2021 & January-2022; that were sequenced and variants were recorded. Patients were invited for a telephonic interview after voluntary and informed consent was obtained from each participant wherein, the demographics, co-morbidities, oxygen requirement and mortality outcomes of the patients were enquired about. Results A total of 200 patients, with 100 from each period were included in the study. Major comorbidities in patients included hypertension, diabetes mellitus and pulmonary disease. Patients who succumbed to the Delta variant (26%) were higher as compared to the Omicron variant (10%); with the elderly (68 ± 9.7 years) having mortality during the Omicron variant. A significantly increased risk for mortality was observed in comorbidities in both Delta and Omicron variants with hypertension (OR:1.3;5.44), diabetes mellitus (OR:0.99;1.94), chronic pulmonary disease (OR:1.6;2.25), chronic kidney disease (OR:3.18;0.89), and smoking (OR:1.74;1.55). Conclusion The study concluded that the Omicron has potential of high transmissibility and milder disease for the population by large, however, it is not a milder strain for patients with comorbidities having a higher risk of adverse outcomes than that of the previously dominant Delta variant.

show abstract

“…30 Soegiarto et al examined total dose inactivated virus vaccination in health workers in Indonesia and disclosed that even fully vaccinated still had a breakthrough infection. 8 Our study showed similar result that the vaccined HCWs still have a risk to be infected.…”

Section: Discussionsupporting

confidence: 82%

“…Nevertheless, the SARS-CoV-2 mutation and various antibody put HCWs at risk for breakthrough infection, even after being fully vaccinated. [6][7][8] Therefore, comprehensive contact tracing has become one of the critical strategies by governments to ensure healthcare workers' and patients' safety. 9 Contact tracing is a crucial mechanism for breaking the chain of infectious diseases by identifying, quarantining, and monitoring contacts of infected individuals.…”

Section: Introductionmentioning

confidence: 99%

Analysis of contact tracing surveillance for COVID-19 among healthcare workers in secondary referral hospital, Indonesia

Asmarawati

¹

,

Sukartini

²

,

Ekasari

³

et al. 2022

F1000Res

Self Cite

0

View full text Add to dashboard Cite

Background: Healthcare workers (HCWs) are more vulnerable to COVID-19 infection. Tracing and screening cases among healthcare workers are essential to overcome the spread of COVID-19. We held surveillance at the second-referral hospital in Surabaya, Indonesia, to inspect the associating factors of infected HCWs. Methods: From 776 HCWs, we conducted a structured retrospective review of all COVID-19-confirmed HCWs and ones having contact with COVID-19 patients between February-July 2021. We associated general characteristics (i.e age, gender, working sites, etc) of the sample with the positive cases, analyzed the vaccination status, then did bivariate and multivariate regression logistic analyses to determine related factors putting HCWs at risk for COVID-19 infection. Results: Bivariate analysis significantly revealed that 72.86% patients had a close contact (OR = 2.61; p<0.05), with medical staffs as the most frequent source (85.71%; OR = 2.19; p=0.033), for > 15 minutes contact duration (90%; OR = 1.1; p<0.05). Healthcare workers wearing proper PPE (N-95 and face shields) were significantly less exposed to COVID-19 (OR = 0.47; p<0.05; and OR = 0.46; p<0.05). Even fully-vaccinated samples were still prone to infection. (OR=1.25; p= 0.042). Common symptoms consisted of fever, rhinorrhea, sore throat, and vomiting (p=0.025l p=0.002; p<0.05; p=0.002). Multivariate regression logistic analysis disclosed that the use of N95 masks, contact duration >15 minutes, and the vaccine were the most influential factors (aOR = 1.72. 95% CI (1.029-2.88); aOR = 3.92. 95% CI (1.75-8.78); aOR = 0.39. 95% CI (0.13-0.82 )) Conclusions: Close contact, lack of compliance in wearing N95 masks, and unvaccinated status are risk factors for COVID-19 exposure to HCWs; thus, to achieve maximum prevention of intra-hospital transmission, the use of N-95 masks, contact avoidance, and vaccination, along with immediate tracing and strict health-protocols are all compulsory.

show abstract

“…32 Soegiarto et al examined total dose inactivated virus vaccination in health workers in Indonesia and disclosed that even fully vaccinated still had a breakthrough infection. 10 Our study showed similar result that the vaccined HCWs still have a risk to be infected.…”

Section: Discussionsupporting

confidence: 82%

“…7 Nevertheless, the SARS-CoV-2 mutation and various antibody put HCWs at risk for breakthrough infection, even after being fully vaccinated. [8][9][10] Therefore, comprehensive contact tracing has become one of the critical strategies by governments to ensure healthcare workers' and patients' safety. 11 Contact tracing is a crucial mechanism for breaking the chain of infectious diseases by identifying, quarantining, and monitoring contacts of infected individuals.…”

Section: Introductionmentioning

confidence: 99%

Analysis of contact tracing surveillance for COVID-19 among healthcare workers in secondary referral hospital, Indonesia

Asmarawati

¹

,

Sukartini

²

,

Ekasari

³

et al. 2022

F1000Res

Self Cite

0

View full text Add to dashboard Cite

Background: Healthcare workers (HCWs) are more vulnerable to COVID-19 infection. Tracing and screening cases among healthcare workers are essential to overcome the spread of COVID-19. We held surveillance at the second-referral hospital in Surabaya, Indonesia, to inspect the associating factors of infected HCWs. Methods: From 776 HCWs, we conducted a structured retrospective review of all COVID-19-confirmed HCWs and ones having contact with COVID-19 patients between February-July 2021. We associated general characteristics (i.e age, gender, working sites, etc) of the sample with the positive cases, analyzed the vaccination status, then did bivariate and multivariate regression logistic analyses to determine related factors putting HCWs at risk for COVID-19 infection. Results: Bivariate analysis significantly revealed that 72.86% patients had a close contact (OR = 2.61; p<0.05), with medical staffs as the most frequent source (85.71%; OR = 2.19; p=0.033), for > 15 minutes contact duration (90%; OR = 1.1; p<0.05). Healthcare workers wearing proper PPE (N-95 and face shields) were significantly less exposed to COVID-19 (OR = 0.47; p<0.05; and OR = 0.46; p<0.05). Even fully-vaccinated samples were still prone to infection. (OR=1.25; p= 0.042). Common symptoms consisted of fever, rhinorrhea, sore throat, and vomiting (p=0.025l p=0.002; p<0.05; p=0.002). Multivariate regression logistic analysis disclosed that the use of N95 masks, contact duration >15 minutes, and the vaccine were the most influential factors (aOR = 1.72. 95% CI (1.029-2.88); aOR = 3.92. 95% CI (1.75-8.78); aOR = 0.39. 95% CI (0.13-0.82 )) Conclusions: Close contact, lack of compliance in wearing N95 masks, and unvaccinated status are risk factors for COVID-19 exposure to HCWs; thus, to achieve maximum prevention of intra-hospital transmission, the use of N-95 masks, contact avoidance, and vaccination, along with immediate tracing and strict health-protocols are all compulsory.

show abstract

Hypertension Is Associated With Antibody Response and Breakthrough Infection in Health Care Workers Following Vaccination With Inactivated SARS-CoV-2

Cited by 4 publications

References 31 publications

Is Omicron really mild? - Comparative analysis of comorbidities and disease outcomes associated with SARS-CoV-2 Omicron (B.1.1.529) and Delta (B.1.617.2) variants

Is Omicron really mild? - Comparative analysis of comorbidities and disease outcomes associated with SARS-CoV-2 Omicron (B.1.1.529) and Delta (B.1.617.2) variants

Analysis of contact tracing surveillance for COVID-19 among healthcare workers in secondary referral hospital, Indonesia

Analysis of contact tracing surveillance for COVID-19 among healthcare workers in secondary referral hospital, Indonesia

Contact Info

Product

Resources

About