Hypertension in Wilms tumor

Hsiao, Wendy; Laskin, Benjamin L.

doi:10.1007/s00467-023-06011-y

Cited by 2 publications

(3 citation statements)

References 67 publications

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“…Although 30% of these patients experienced a grade 2 hypertension, the ultimate incidence of life-threatening complications is very low. Hypertension at diagnosis is associated with a higher eGFR at end of treatment, possibly suggesting hyperfiltration, which supports the proposed recommendations for follow-up in the review [ 1 ].…”

supporting

confidence: 77%

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The incidence and outcome of hypertension at diagnosis in children with a kidney tumor

van den Berg,

Raymakers-Janssen,

Asperen

et al. 2024

Pediatr Nephrol

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supporting

confidence: 77%

“…With great interest we have read the review about hypertension in Wilms tumor [ 1 ]. The review notes a substantial range of 22–79% in the prevalence of hypertension at the time of diagnosis.…”

mentioning

confidence: 99%

The incidence and outcome of hypertension at diagnosis in children with a kidney tumor

van den Berg,

Raymakers-Janssen,

Asperen

et al. 2024

Pediatr Nephrol

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“…Although other studies with shorter follow-up are less impactful, a recent meta-analysis of all studies confirmed higher eGFR in children undergoing NSS (116 ml/min/1.73 m 2 vs. 98 ml/min/1.73 m 2 ) [ 73 ]. Recommendations for surveillance of kidney function and hypertension in WT survivors have been published, although they are based on personal opinion, and extrapolation from solitary kidney and cancer survivorship literature [ 74 ].…”

Section: Kidney Outcomesmentioning

confidence: 99%

The rationale for nephron-sparing surgery in unilateral non-syndromic Wilms tumour

Taghavi,

Sarnacki,

Blanc

et al. 2023

Pediatr Nephrol

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The central question of nephron-sparing surgery in unilateral non-syndromic Wilms tumour sits at a crossroads between surgery, oncology, and nephrology. There has been a significant paradigm shift in paediatric oncology towards reducing toxicity and addressing long-term treatment-related sequalae amongst childhood cancer survivors. After paediatric nephrectomy and 30–50 years of follow-up, 40% of patients will have chronic kidney disease, including 22% with hypertension and 23% with albuminuria. It is difficult to predict which patients will progress to develop hypertension, reduced glomerular filtration rate, albuminuria, and a higher cardiovascular risk. For these reasons, nephron-sparing surgery when it is technically feasible must be considered. To decrease the incidence of positive surgical margins (viable tumour present at a resection margin), incomplete lymph node sampling, and complications, these procedures should be performed at specialist and experienced reference centres. Based on the impacts of individual treatment pathways, survivors of childhood WT need to be followed through adulthood for early detection of chronic kidney disease, hypertension, and prevention of cardiovascular events.

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Hypertension in Wilms tumor

Cited by 2 publications

References 67 publications

The incidence and outcome of hypertension at diagnosis in children with a kidney tumor

The incidence and outcome of hypertension at diagnosis in children with a kidney tumor

The rationale for nephron-sparing surgery in unilateral non-syndromic Wilms tumour

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