Hypertension in Metabolic Syndrome: Novel Insights

Katsimardou, Alexandra; Imprialos, Κonstantinos; Stavropoulos, Konstantinos; Sachinidis, Alexandros; Doumas, Michalis; Athyros, Vasilios G.

doi:10.2174/1573402115666190415161813

Cited by 52 publications

(30 citation statements)

References 70 publications

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“…This finding was in accordance with other studies (14,15) because many predisposing conditions which rising in the MS prevalence during aging, such as insulin resistance, obesity and hypertension (15). Hypertension was the major component of MS in our study followed by central obesity, and this finding was similar to a comprehensive review of Katsimardou et al that hypertension was present in almost 80% of patients with MS (16). Regarding hypertension in MS, the pathophysiologic mechanism had been proposed that insulin resistance can stimulate the sympathetic nervous system and decrease nitric oxide production, contributing to increases in blood pressure (17,18).…”

Section: Resultssupporting

confidence: 90%

Increased Uric Acid and Life Style Factors Associated with Metabolic Syndrome in Thais

Klongthalay¹,

Suriyaprom²

2020

Ethiop J Health Sci

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BACKGROUND: The prevalence of metabolic syndrome (MS) has been continually increasing in developing countries especially in Thailand. Although insulin resistance and central obesity are initially considered as significant risk factors, the other causal factors leading to the development of MS continue to challenge the investigators. The aims of this study were to evaluate the prevalence of MS in Pathum Thani province, Thailand and to investigate the relationship between MS and risk factors.METHODS: This cross-sectional study was performed with 202 Thai volunteers. Anthropometric-biochemical variables and blood pressures in each subject were measured.RESULTS: Almost one-third (32.7%) of the participants were diagnosed with MS based on the harmonized criteria, and one of the most significant risk factors is the elevated blood pressure. Weight, BMI, waist and hip circumferences, waist-hip ratio, blood pressure, glucose, triglycerides and uric acid were significantly higher in subjects with MS subjects. However, HDL-C levels were significantly lower in subjects with MS, compared to subjects without MS (p<0.001). The results of regression model after adjustment for age and gender showed that the increased serum uric acid level (OR=1.31, 95%CI: =1.04-1.66), cigarette smoking (OR=3.72, 95%CI: =1.51-9.15) and physical activity (OR=0.36, 95%CI: =0.19-0.67) were significantly related to MS.CONCLUSIONS: These findings suggest that the decrease of uric acid level, the promotion of physical activity and smoking cessation may decrease the risk of developing MS among Thais.

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Section: Resultssupporting

confidence: 90%

Increased Uric Acid and Life Style Factors Associated with Metabolic Syndrome in Thais

Klongthalay¹,

Suriyaprom²

2020

Ethiop J Health Sci

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“…We also found hypertension a compulsory risk factor of MetS. Consistently, almost 80% of the patients affected by MetS present elevated blood pressure (41). Lowered histidine and imidazole levels could be linked to an impairment in the concentration of the endogenous ligands of the imidazoline and a 2adrenogenic receptor, ultimately associated to hypertension episodes (27,28).…”

Section: Discussionsupporting

confidence: 69%

A molecular signature for the Metabolic Syndrome by urine metabolomics

Bruzzone

Gil‐Redondo

Seco

et al. 2021

Preprint

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BACKGROUND. Metabolic syndrome (MetS) is a multimorbid long-term condition without consensual medical definition and a diagnostic based on compatible symptomatology. Here we have investigated the molecular signature of MetS in urine.METHODS. We used NMR-based metabolomics to investigate a European cohort including urine samples from 11,754 individuals (18–75 years old, 41% females), designed to populate all the intermediate conditions in MetS, from subjects without any risk factor up to individuals with developed MetS (4–5%, depending on the definition). A set of quantified metabolites were integrated from the urine spectra to obtain metabolic models (one for each definition), to discriminate between individuals with MetS.RESULTS. MetS progression produces a continuous and monotonic variation of the urine metabolome, characterized by up- or down-regulation of the pertinent metabolites (19 in total, including glucose, lipids, aromatic amino acids, salicyluric acid, maltitol, trimethylamine N-oxide, and p-cresol sulfate) with some of the metabolites associated to MetS for the first time. This metabolic signature, based solely on information extracted from the urine spectrum, adds a molecular dimension to MetS definition and it was used to generate models that can identify subjects with MetS (AUROC values between 0.86 and 0.92). This signature is particularly suitable to add meaning to the conditions that are in the interface between healthy subjects and MetS patients. Aging and non-alcoholic fatty liver disease are also risk factors that may enhance MetS probability, but they do not directly interfere with the metabolic discrimination of the syndrome.CONCLUSIONS. Urine metabolomics, studied by NMR spectroscopy, unravelled a set of metabolites that concomitantly evolve with MetS progression, that were used to derive and validate a molecular definition of MetS and to discriminate the conditions that are in the interface between healthy individuals and the metabolic syndrome.

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“…We also found hypertension a compulsory risk factor of MetS. Consistently, almost 80% of the patients affected by MetS present elevated blood pressure [44]. Lowered histidine and imidazole levels could be linked to an impairment in the concentration of the endogenous ligands of the imidazoline and α 2 -adrenogenic receptor, ultimately associated to hypertension episodes [29,30].…”

Section: Discussionsupporting

confidence: 69%

A molecular signature for the metabolic syndrome by urine metabolomics

Bruzzone

Gil‐Redondo

Seco³

et al. 2021

Cardiovasc Diabetol

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Background Metabolic syndrome (MetS) is a multimorbid long-term condition without consensual medical definition and a diagnostic based on compatible symptomatology. Here we have investigated the molecular signature of MetS in urine. Methods We used NMR-based metabolomics to investigate a European cohort including urine samples from 11,754 individuals (18–75 years old, 41% females), designed to populate all the intermediate conditions in MetS, from subjects without any risk factor up to individuals with developed MetS (4–5%, depending on the definition). A set of quantified metabolites were integrated from the urine spectra to obtain metabolic models (one for each definition), to discriminate between individuals with MetS. Results MetS progression produces a continuous and monotonic variation of the urine metabolome, characterized by up- or down-regulation of the pertinent metabolites (17 in total, including glucose, lipids, aromatic amino acids, salicyluric acid, maltitol, trimethylamine N-oxide, and p-cresol sulfate) with some of the metabolites associated to MetS for the first time. This metabolic signature, based solely on information extracted from the urine spectrum, adds a molecular dimension to MetS definition and it was used to generate models that can identify subjects with MetS (AUROC values between 0.83 and 0.87). This signature is particularly suitable to add meaning to the conditions that are in the interface between healthy subjects and MetS patients. Aging and non-alcoholic fatty liver disease are also risk factors that may enhance MetS probability, but they do not directly interfere with the metabolic discrimination of the syndrome. Conclusions Urine metabolomics, studied by NMR spectroscopy, unravelled a set of metabolites that concomitantly evolve with MetS progression, that were used to derive and validate a molecular definition of MetS and to discriminate the conditions that are in the interface between healthy individuals and the metabolic syndrome.

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Hypertension in Metabolic Syndrome: Novel Insights

Cited by 52 publications

References 70 publications

Increased Uric Acid and Life Style Factors Associated with Metabolic Syndrome in Thais

Increased Uric Acid and Life Style Factors Associated with Metabolic Syndrome in Thais

A molecular signature for the Metabolic Syndrome by urine metabolomics

A molecular signature for the metabolic syndrome by urine metabolomics

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