Hypertension in Diabetes Study (HDS): II. Increased risk of cardiovascular complications in hypertensive type 2 diabetic patients

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doi:10.1097/00004872-199303000-00013

Cited by 158 publications

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“…Demographics, lifestyle variables, dietary habits, and personal medical and family history were obtained using a predesigned questionnaire based on factors associated with dysglycemia found in other populations. [9][10][11][12][13][14][15][18][19][20][21][22] Participants were instructed to fast overnight for 8 to 14 hours, and fasting blood sample was collected to estimate fasting plasma glucose (FPG) and glycated hemoglobin (HbA1c). Another sample was collected 1 hour after ingestion of 50-g glucose solution (CASCO NERL Diagnostics, East Providence, RI, USA) for estimating plasma glucose (1-hour oral glucose tolerance test; 1 h-OGTT).…”

Section: Study Design and Data Collectionmentioning

confidence: 99%

The Association Between Dietary Habits and Other Lifestyle Indicators and Dysglycemia in Saudi Adults Free of Previous Diagnosis of Diabetes

Jambi

Enani

Malibary

et al. 2020

Nutr Metab Insights

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Objective: Study the association of dietary habits and other indicators of lifestyle with dysglycemia in Saudi adults. Methods: In a cross-sectional design, data were obtained from 1403 Saudi adults (⩾20 years), not previously diagnosed with diabetes. Demographics, lifestyle variables and dietary habits were obtained using a predesigned questionnaire. Fasting plasma glucose, glycated hemoglobin and 1-hour oral glucose tolerance test were used to identify dysglycemia. Regression analysis was performed to determine the associations of dietary factors and other indicators of lifestyle with dysglycemia. Results: A total 1075 adults (596 men, and 479 women) had normoglycemia, and 328 (195 men, and 133 women) had dysglycemia. Following adjustment for age, BMI and waist circumference, in men the weekly intake of 5 portions or more of red meat and Turkish coffee were associated with decreased odds of having dysglycemia odds ratio (OR) 0.444 (95% CI: 0.223, 0.881; P = .02) and 0.387 (95% CI: 0.202, 0.74; P = .004), respectively. In women, the intake of fresh juice 1 to 4 portions per week and 5 portions or more were associated with OR 0.603 (95% CI: 0.369, 0.985; P = .043) and OR 0.511 (95% CI: 0.279, 0.935; P = .029) decreased odds of having dysglycemia, respectively compared with women who did not drink fresh juice. The intake of 5 times or more per week of hibiscus drink was associated with increased odds of having dysglycemia, OR 5.551 (95% CI: 1.576, 19.55, P = .008) compared with women not using such a drink. Other lifestyle factors were not associated with dysglycemia. Conclusion: Dietary practices by studied Saudis have some impact on risk of dysglycemia, with obvious sex differences.

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Section: Study Design and Data Collectionmentioning

confidence: 99%

The Association Between Dietary Habits and Other Lifestyle Indicators and Dysglycemia in Saudi Adults Free of Previous Diagnosis of Diabetes

Jambi

Enani

Malibary

et al. 2020

Nutr Metab Insights

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“…In this context, a leading risk factor for CVD mortality is high blood pressure (BP), which accounts for > 40% of CVD-related deaths worldwide (Danaei et al, 2014). In individuals with type 2 diabetes mellitus (T2DM), elevated BP further increases the risk of CVD (Turner et al, 1993), whilst T2DM itself imposes a risk of coronary heart disease mortality equivalent to that of a prior myocardial infarction (Juutilainen et al, 2005). Moreover, a recent study confirmed a time dependent and additive effect of BP and increasing blood glucose levels on the development of T2DM complications (Stratton et al, 2006).…”

Section: Introductionmentioning

confidence: 99%

Substantial Inter-Subject Variability in Blood Pressure Responses to Glucose in a Healthy, Non-obese Population

Monnard

Fellay²,

Scerri

et al. 2017

Front. Physiol.

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Aim: A large inter-subject variability in the blood pressure (BP) response to glucose drinks has been reported. However, the underlying factors remain elusive and we hypothesized that accompanying changes in glucose metabolism affect these BP responses.Methods: Cardiovascular and glycemic changes in response to a standard 75 g oral-glucose-tolerance-test were investigated in 30 healthy, non-obese males. Continuous cardiovascular monitoring, including beat-to-beat BP, electrocardiographically deduced heart rate and impedance cardiography, was performed during a 30 min baseline and continued up to 120 min after glucose ingestion. Blood samples were taken at baseline, 30, 60, 90, and 120 min for the assessment of glucose, insulin and c-peptide. Additionally, we evaluated body composition by using validated bioelectrical impedance techniques.Results: Individual overall changes (i.e., averages over 120 min) for systolic BP ranged from −4.9 to +4.7 mmHg, where increases and decreases were equally distributed (50%). Peak changes (i.e., peak averages over 10 min intervals) for systolic BP ranged from −1.3 to +9.5 mmHg, where 93% of subjects increased systolic BP above baseline values (similar for diastolic BP) whilst 63% of subjects increased peak systolic BP by more than 4 mmHg. Changes in peak systolic BP were negatively associated with the calculated Matsuda-index of insulin sensitivity (r = −0.39, p = 0.04) but with no other evaluated parameter including body composition. Moreover, besides a trend toward an association between overall changes in systolic BP and total fat mass percentage (r = +0.32, p = 0.09), no association was found between other body composition parameters and overall BP changes.Conclusion: Substantial inter-subject variability in BP changes was observed in a healthy, non-obese subpopulation in response to an oral glucose load. In 63% of subjects, peak systolic BP increased by more than a clinically relevant 4 mmHg. Peak systolic BP changes, but not overall BP changes, correlated with insulin sensitivity, with little influence of body composition.

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“…It has also been shown that hypertension in diabetic patients is observed more often than in nondiabetic individuals ( − ). These associations carry a significant increase in mortality and morbidity due to atherosclerosis and microvascular diabetic complications such as nephropathy and retinopathy ( − ). It is recognized that the management of hypertension especially in the diabetic patient is complicated by multiple factors related to the metabolic state, that is, glucose and lipid levels and insulin resistance.…”

Section: Introductionmentioning

confidence: 99%

Aqueous Extract of Monascus purpureus M9011 Prevents and Reverses Fructose-Induced Hypertension in Rats

Hsieh

Tai

2003

J. Agric. Food Chem.

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This study aimed to determine the antihypertensive and metabolic effects of an aqueous extract of Monascus purpureus M9011 on fructose-induced hypertensive rats. After dietary feeding of fructose for 2 weeks, the rats exhibited significantly higher systolic blood pressure (SBP), mean arterial pressure (MAP), and plasma insulin and triglyceride levels, but lower insulin sensitivity than those in control rats on regular diet. The intragastric loading of fructose-fed rats with M9011 containing gamma-aminobutyric acid (GABA, 1 mg.kg(-)(1).day(-)(1)) prevented the development of fructose-induced hypertension. After fructose-induced hypertension had been established, intragastric loading of M9011 reversed the elevated blood pressure to normal level. Administration of pure GABA at the same dose as that contained in M9011 failed to prevent or reverse hypertension due to fructose consumption. Chronic M9011 treatment significantly suppressed the fructose-induced elevation in total cholesterol levels and enhanced the recovery of high-density lipoprotein cholesterol/total cholesterol ratio. However, M9011 treatment did not alter insulin sensitivity or the plasma levels of insulin, glucose, and triglyceride in fructose-fed and control rats. The present results suggest that M9011 is a novel, potent, food-based antihypertensive agent with the capability to improve long-term control of cholesterol metabolism in rats and may be of importance in clinical application for the hypertensive diabetic population.

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Hypertension in Diabetes Study (HDS): II. Increased risk of cardiovascular complications in hypertensive type 2 diabetic patients

Cited by 158 publications

References 0 publications

The Association Between Dietary Habits and Other Lifestyle Indicators and Dysglycemia in Saudi Adults Free of Previous Diagnosis of Diabetes

The Association Between Dietary Habits and Other Lifestyle Indicators and Dysglycemia in Saudi Adults Free of Previous Diagnosis of Diabetes

Substantial Inter-Subject Variability in Blood Pressure Responses to Glucose in a Healthy, Non-obese Population

Aqueous Extract of Monascus purpureus M9011 Prevents and Reverses Fructose-Induced Hypertension in Rats

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