Hypertension in Blacks

Muntner, Paul; Abdalla, Marwah; Correa, Adolfo; Griswold, Michael; Hall, John E.; Jones, Daniel W.; Mensah, George A.; Sims, Mario; Shimbo, Daichi; Spruill, Tanya M.; Tucker, Katherine L.; Appel, Lawrence J.

doi:10.1161/hypertensionaha.117.09061

Cited by 23 publications

(18 citation statements)

References 76 publications

(77 reference statements)

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“…Moreover, measurement of 24-h BP phenotypes provided limited incremental value as a predictor of CV/renal disease risk among African Americans, by differing in prediction by one less or more event in ~ 250 (range 250–1,000 depending on the 24-h BP phenotype) predictions, compared to clinic BP values. Even though several similar studies comparing clinic and 24-h BPs have been reported in Caucasian and Asian populations 24 , 25 , this is the first study in African Americans that directly compared the predictive effects of outpatient BP levels versus 24-h BP phenotypes in predicting CV/renal disease events 32 .…”

Section: Discussionmentioning

confidence: 95%

“…In addition, masked HTN has been associated with increased CVD risk factors 43 – 45 . Most of these studies have been conducted in European and Asian populations 32 . In addition, ABPM levels are also valuable in evaluating BP variability which has been associated with target-organ damage 46 , 47 .…”

Section: Discussionmentioning

confidence: 99%

“…Few studies have evaluated the effect of ABPM on long-term CV/renal disease morbidity and mortality in African American individuals when compared to clinic BP values 32 . Most notable of this is Jackson Heart Study (JHS), which has shown that various 24-h BP phenotypes such as lack of nocturnal dipping, BP variability, and masked HTN were negatively associated with intermediate target-organ damage markers such as glomerular filtration rate decline (chronic kidney disease), increased left ventricular mass index, and increased carotid artery intimal-media thickness when controlled for clinic BPs indicating superiority of ABPM in predicting these intermediate outcomes 48 – 53 .…”

Section: Discussionmentioning

confidence: 99%

“…All CV/renal disease events were verified and adjudicated by reviewing patient medical records by board-certified physicians. In addition, medical records of all individuals who were determined to have not had an event for 10 years were also reviewed prior to designating them as controls unlike many of the other studies that have only verified positive events 32 . Despite its strengths, we acknowledge our study’s limitations.…”

Section: Discussionmentioning

confidence: 99%

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Twenty-four-hour versus clinic blood pressure levels as predictors of long-term cardiovascular and renal disease outcomes among African Americans

Kidambi

Wang

Chelius

et al. 2020

Sci Rep

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In Caucasian and Asian populations, evidence suggests that 24-h blood pressures (BP) are more predictive of long-term cardiovascular events than clinic BP. However, few long-term studies have evaluated the predictive value of 24-h BP phenotypes (24-h, daytime, nighttime) among African Americans (AA). The purpose of this study is to evaluate the added value of 24-h BP phenotypes compared to clinic BP in predicting the subsequent fatal and non-fatal cardiovascular/renal disease events in AA subjects. AA subjects (n = 270) were initially studied between 1994 and 2006 and standardized clinic BP measurements were obtained during screening procedures for a 3-day inpatient clinical study during which 24-h BP measurements were obtained. To assess the subsequent incidence of cardiovascular and renal disease events, follow-up information was obtained and confirmed by review of paper and electronic medical records between 2015 and 2017. During a mean follow-up of 14 ± 4 years, 50 subjects had one or more fatal or non-fatal cardiovascular/renal disease events. After adjustment for covariates, clinic systolic and diastolic BP were strongly associated with cardiovascular/renal disease events and all-cause mortality (p < 0.0001). Twenty-four-hour BP phenotypes conferred a small incremental advantage over clinic BP in predicting cardiovascular/renal events, which was limited to making a difference of one predicted event in 250-1,000 predictions depending on the 24-h BP phenotype. Nocturnal BP was no more predictive than the other 24-h BP phenotypes. In AA, 24-h BP monitoring provides limited added value as a predictor of cardiovascular/ renal disease events. Larger studies are needed in AA to confirm these findings.

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Section: Discussionmentioning

confidence: 95%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

See 2 more Smart Citations

Twenty-four-hour versus clinic blood pressure levels as predictors of long-term cardiovascular and renal disease outcomes among African Americans

Kidambi

Wang

Chelius

et al. 2020

Sci Rep

View full text Add to dashboard Cite

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“…Hypertension is the classic disease phenotype to demonstrate this difference. It is well known that the effect of electrolyte intake on blood pressure dramatically differs between African Americans and European-decent individuals [13]. This may suggest an underlying physiological difference in disease pathogenesis and may explain differences in response to drug therapies.…”

Section: Changing the Perspectivementioning

confidence: 99%

Leaving some behind: the growing gap in precision medicine for minority populations

Perera

2018

Expert Review of Precision Medicine and Drug Development

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Will the 2021 USPSTF Hypertension Screening Recommendation Decrease or Worsen Racial/Ethnic Disparities in Blood Pressure Control?

Ferdinand

Brown

2021

JAMA Netw Open

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Hypertension, defined as systolic blood pressure (BP) greater than or equal to 130 mm Hg or diastolic BP greater than or equal to 80 mm Hg, or currently using medication to lower BP, is a potent cardiovascular disease (CVD) risk factor affecting 45.4% of the adult US population. 1 The highest prevalence is among non-Hispanic/Latinx Black adults (57.1%), for whom earlier age of onset and treatment resistance confer greater hypertension-related CVD, including coronary artery disease, congestive heart failure, cerebrovascular accident, and end-stage renal disease. Although the overall Author affiliations and article information are listed at the end of this article.

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Hypertension in Blacks

Cited by 23 publications

References 76 publications

Twenty-four-hour versus clinic blood pressure levels as predictors of long-term cardiovascular and renal disease outcomes among African Americans

Twenty-four-hour versus clinic blood pressure levels as predictors of long-term cardiovascular and renal disease outcomes among African Americans

Leaving some behind: the growing gap in precision medicine for minority populations

Will the 2021 USPSTF Hypertension Screening Recommendation Decrease or Worsen Racial/Ethnic Disparities in Blood Pressure Control?

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