Hypertension, hyperreninemia and a solitary renal cyst in an adolescent

Rose, H; Pruitt, Albert W.

doi:10.1016/0002-9343(76)90341-7

Cited by 17 publications

(5 citation statements)

References 11 publications

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“…There are only several case reports on the presence of hypertension in adult patients with solitary renal cysts [85,89] and even less case reports in children [90,91]. We did not find any hypertensive child among children with solitary renal cyst in our renal division using both clinic and ambulatory 24-hour blood pressure measurement [49].…”

Section: Hypertension In Children With Simple Renal Cystsmentioning

confidence: 56%

“…Hypertension is usually hyperreninemic as has been shown in several reports where the authors measure plasma renin activity in their hypertensive patients [86,87,90,92,93]. Treatment of hypertension in children with simple cyst is pharmacological and surgical.…”

Section: Hypertension In Children With Simple Renal Cystsmentioning

confidence: 99%

“…Pharmacological treatment is based on the evidence that most patients have hyperreninemic hypertension and therefore ACE-inhibitors are the drugs of choice. However, surgical treatment is usually preferred, because drainage, aspiration, evacuation or sclerosing of the cyst has been shown to be effective in controlling hypertension and hyperreninism in patients with simple renal cyst [86][87][88][89][90]94]. It has to be stated that all other forms of cystic kidney diseases have to be excluded, especially ADPKD, before definitive diagnosis of simple renal cyst is made in a child.…”

Section: Hypertension In Children With Simple Renal Cystsmentioning

confidence: 99%

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Hypertension in Children with Cystic Kidney Diseases

Seeman

2006

CHYR

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Cystic kidney diseases are one of the most common urogenital malformations and are responsible for a substantial morbidity and mortality. Autosomal recessive polycystic kidney disease (ARPKD), autosomal dominant polycystic kidney disease (ADPKD), multicystic dysplastic kidney (MCDK) and juvenile nephronophthisis (JNP) are the most common and most serious cystic kidney diseases.Hypertension is the main risk factor for progression of various nephropathies, including cystic kidney diseases. The prevalence of hypertension varies depending on the method of BP measurement and the type of cystic disease. Ambulatory BP monitoring (ABPM) is a more potent tool for detection of hypertension than the clinic BP. Hypertension is most common in children with ARPKD, the prevalence ranges between 60 -100% and hypertension accounts for substantial cardiovascular morbidity and mortality in these patients. In children with ADPKD the prevalence of hypertension is 15 -38% despite normal renal function and is the most important treatable factor for progression of the disease. Hypertension is a relative uncommon finding in children with MCDK (0 -20%) and is more often caused by contralateral kidney damage than by affected multicystic kidney. Children with JNP are usually normotensive until the late stages of renal insufficiency.The drugs of first choice in children with cystic kidney diseases are ACE-inhibitors. Most children with ARPKD have severe hypertension and require combination therapy with 2 -4 drugs (beta-blockers, diuretics, calcium channel blockers). Treatment of hypertension is important not only to delay progression of the kidney disease but also to decrease the cardiovascular morbidity and mortality.

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Section: Hypertension In Children With Simple Renal Cystsmentioning

confidence: 56%

Section: Hypertension In Children With Simple Renal Cystsmentioning

confidence: 99%

Section: Hypertension In Children With Simple Renal Cystsmentioning

confidence: 99%

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Hypertension in Children with Cystic Kidney Diseases

Seeman

2006

CHYR

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“…There have been several descriptions of simple cysts resulting in hypertension with elevated renin from the affected kidney, which resolves following cyst decompression. [21][22][23] Interestingly, a longitudinal study has demonstrated an increased risk of developing hypertension in middle-aged men with renal cysts, 24 and a case series of patients undergoing aspiration of simple cysts has shown that hypertension is more common among those with larger cysts. 25 Adult polycystic kidney disease (APKD) frequently leads to the development of hypertension, which can occur before there is a significant decline in renal function.…”

Section: Discussionmentioning

confidence: 99%

Hypertension and Hydronephrosis: Rapid Resolution of High Blood Pressure Following Relief of Bilateral Ureteric Obstruction

Chalisey

Karim

2012

J GEN INTERN MED

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Hypertension secondary to hydronephrosis is not commonly reported in the medical literature. Tubuloglomerular feedback and the renin-angiotensin-aldosterone axis are thought to mediate this process. We describe a patient presenting with acute kidney injury and bilateral hydronephrosis secondary to pelvic malignancy in which peripheral venous renin and aldosterone were elevated. Her blood pressure improved rapidly following insertion of bilateral nephrostomies. The speed of resolution of hypertension following relief of obstruction suggests that humorally mediated vasoconstriction can play an important role in the mechanism by which hydronephrosis causes hypertension. We also discuss other causes of renal parenchymal compression that may lead to the development of hypertension.

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“…Hypertension occurs as a result of compression exerted by the cyst on the vascular structures of the surrounding parenchyma, which causes progressive ischemia and activation of the renin-angiotensin-aldosterone system. [5][6][7][8] In humans, symptomatic renal cysts are treated by drainage and ultrasound-guided percutaneous injection of alcohol. [9][10][11][12][13][14][15][16][17][18][19][20][21][22][23][24][25][26][27][28] In the present case, the SRC caused dilatation of the papillary duct and renal pelvis, but renal function was not noticeably compromised.…”

mentioning

confidence: 99%

Obstructive Renal Cyst in a Dog: Ultrasonography-Guided Treatment Using Puncture Aspiration and Injection with 95% Ethanol

Zatelli¹,

Bonfanti²,

D’Ippolito³

2005

J Vet Int Med

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A 12-year-old, intact male, mixed-breed dog was evaluated after surgical removal of a mast cell tumor from the shoulder. Results of laboratory tests were within the reference ranges, but examination of urinary sediment identified epithelial cells of the upper urinary tract and microscopic hematuria. Abdominal ultrasound examination performed after a 12-hour fast identified a simple cyst in the left kidney. The cyst was approximately 26 mm in diameter, was anechoic, and had a thin, slightly hyperechoic wall with distal acoustic enhancement accompanied by dilatation of the caudal papillary duct and renal pelvis (Fig 1). Excretory urography with iopamidol a contrast (800 mg/kg IV) confirmed the presence of dilatation of the left renal pelvis and collecting system (Fig 2).Drainage and ultrasound-guided percutaneous injection of 95% alcohol into the cyst were performed. After a 12hour fast, the dog was anesthetized with propofol b (6.5 mg/ kg IV, followed by 1 mg/kg as needed), placed in dorsal recumbency, and prepared for standard surgical intervention. A 23-gauge spinal needle c was inserted into the cyst under ultrasound guidance and connected to a 50-cm extension set with a 3-way valve. A portion of the drained material was submitted for cytologic examination and another portion was placed in a sterile container for bacteriologic culture. Alcohol injection was performed via the spinal catheter by using a volume of 95% ethanol equal to approximately one half of the volume that had been drained. The alcohol was removed after 3 minutes and the injection was repeated with 2% lidocaine (10%, vol/vol) added to the alcohol solution. The liquid was left in place for 3 minutes and again drained.Cytologic examination of the cystic liquid identified the presence of epithelial cells but no evidence of neoplasia or infection. Results of bacteriologic culture were negative. The animal was monitored for complications by clinical examination, CBC, and abdominal ultrasonography 24 and 48 hours after the procedure, and no evidence was found of short-term complications. Successive ultrasonographic and radiographic examinations with contrast medium by excretory urography after 20 days identified resolution of ec-From the Clinica

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Hypertension, hyperreninemia and a solitary renal cyst in an adolescent

Cited by 17 publications

References 11 publications

Hypertension in Children with Cystic Kidney Diseases

Hypertension in Children with Cystic Kidney Diseases

Hypertension and Hydronephrosis: Rapid Resolution of High Blood Pressure Following Relief of Bilateral Ureteric Obstruction

Obstructive Renal Cyst in a Dog: Ultrasonography-Guided Treatment Using Puncture Aspiration and Injection with 95% Ethanol

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