Hypertension Following X-Irradiation of the Kidneys

Influence of X-Irradiation of the Dog Kidney on Erythropoietin Production

“…C o g a n et al (16) is the primarily affected portion ofthe kidney and the tubular atrophy is secondary. These findings are similar to those reported by other investigators (5,16,21,22,23).…”

“…Previous work by Wilson et al (23) has suggested that X-irradiation increases the suscepti bility of the renal arteries to hypertensive damage. Additional stu dies by these workers (26) have revealed that the vascular lesions observed in severe hypertension are identical with those found after X-irradiation.…”

“…Several workers (23,24,25) have reported experimental ob servations on the relationship of hypertension to structural renal damage after X-irradiation of the kidneys. Previous work by Wilson et al (23) has suggested that X-irradiation increases the suscepti bility of the renal arteries to hypertensive damage.…”

Seltene Formen renaler Hypertonie

“…Elevation of blood pressure values developed in nearly all cases desribed in the literature after a latent interval of several years [41,47,57]. In our patient severe hypertension occurred 8 years after ra-diation therapy of 4,000 rad for seminoma.…”

Tension and the Artery: The Experimental Elucidation of Pseudo-Uraemia and Malignant Nephrosclerosis

“…The choice of the rat was most fortunate because, like man, it develops permanent hypertension after constriction of only one renal artery, and so we were able to study the effect of hypertension on an untouched kidney in the absence of renal failure. In these 'two-kidney' experiments we observed acute vascular crises, some of which presented with convulsions and coma as in human hypertensive encephalopathy, others with weakness, cyanosis and rapid loss of weight (Wilson & Byrom, 1939, 1941, and after death we were able to demonstrate in the untouched kidney the full picture of malignant nephrosclerosis, matching lesion for lesion, and so to complete the experimental proof of Volhard's clinico-pathological concept of primary malignant hypertension.…”