Hypertension as a Risk Factor for Heart Failure

Kannan, Arun; Janardhanan, Rajesh

doi:10.1007/s11906-014-0447-7

Cited by 55 publications

(38 citation statements)

References 67 publications

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“…Although it is unclear whether aggressively managing cardiac AE risk factors will result in a reduction in cardiac failure events, it is possible that controlling risk factors reduces event occurrences. Because hypertension generally increases the risk for congestive heart failure and predates it in a majority of cases, 44,45 monitoring and aggressively controlling high blood pressure at the start and during treatment with carfilzomib is critical. In addition, dyspnea LVEF (%) change from baseline minutes.…”

Section: Discussionmentioning

confidence: 99%

Analysis of carfilzomib cardiovascular safety profile across relapsed and/or refractory multiple myeloma clinical trials

et al. 2018

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Section: Discussionmentioning

confidence: 99%

Analysis of carfilzomib cardiovascular safety profile across relapsed and/or refractory multiple myeloma clinical trials

et al. 2018

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“…Ventricular hypertrophy is characterized by increased ventricular wall thickness as a means to decrease wall tension and cardiac stress. Sustained pathological hypertrophic remodeling can lead to arrhythmias, heart failure, and sudden death [4]. …”

Section: Introductionmentioning

confidence: 99%

Cardiac inositol 1,4,5-trisphosphate receptors

Garcia

Boehning

2017

Biochimica et Biophysica Acta (BBA) - Molecular Cell Research

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Calcium is a second messenger that regulates almost all cellular functions. In cardiomyocytes, calcium plays an integral role in many functions including muscle contraction, gene expression, and cell death. Inositol 1,4,5-trisphosphate receptors (IP3Rs) are a family of calcium channels that are ubiquitously expressed in all tissues. In the heart, IP3Rs have been associated with regulation of cardiomyocyte function in response to a variety of neurohormonal agonists, including those implicated in cardiac disease. Notably, IP3R activity is thought to be essential for mediating the hypertrophic response to multiple stimuli including endothelin-1 and angiotensin II. In this review, we will explore the functional implications of IP3R activity in the heart in health and disease.

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“…To further assess whether patients in the low C‐peptide group actually showed sympathetic activation, we focused on blood pressure data. It is widely accepted that sympathetic activation induces blood pressure elevation, and we previously reported significant elevation of self‐measured systolic blood pressure in the morning at home to be sustained for more than 2 weeks after the earthquake in 142 hypertensive patients affected by the Great East Japan Earthquake. As the data of blood pressure in the morning of the participants in the present study were unavailable, we compared clinical blood pressure levels 1 month after the earthquake with those obtained at 3 months, with the latter being assumed to reflect the pre‐earthquake levels.…”

Section: Discussionmentioning

confidence: 98%

Impacts of the Great East Japan Earthquake on diabetic patients

Tanaka

Imai

Satoh

et al. 2015

J of Diabetes Invest

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Aims/IntroductionWe investigated impacts of the Great East Japan Earthquake on diabetic patients and characterized those with disaster-susceptible diabetes.Materials and MethodsWe enrolled 497 diabetic patients who had been followed at hospitals in devastated areas. We collected metabolic parameters prospectively, 1 and 3 months after the earthquake, and retrospectively for pre-earthquake time-points. Questionnaire surveys were carried out regarding earthquake-related damage and post-earthquake lifestyle alterations. Available data were analyzed to examine associations with post-earthquake glycosylated hemoglobin alterations.ResultsThe mean glycosylated hemoglobin level of the participants was not elevated at 1 month, and was significantly decreased at 3 months as compared with the pre-earthquake glycosylated hemoglobin. There were no significant differences in earthquake-related damage or lifestyle alterations between the improved and worsened glycemic control groups according to the data obtained from the questionnaire survey. As reported, fasting serum C-peptide levels were significantly lower in the worsened glycemic control group (P < 0.05). Notably, plasma noradrenaline levels were significantly higher in the worsened glycemic control group (P < 0.05). Furthermore, at 1 month after the earthquake, the plasma noradrenaline level was significantly higher in the low C-peptide group (fasting serum C-peptide <1.0 ng/mL) than in the high C-peptide group (fasting serum C-peptide ≥1.0 ng/mL), but this difference had disappeared by 3 months after the earthquake. These findings show that post-earthquake plasma noradrenaline levels were temporarily increased in the low C-peptide group.ConclusionsSympathetic nerve activation might be elicited more easily in subjects with lower endogenous insulin secretory capacity, and could be involved in the mechanism underlying post-earthquake worsening of glycemic control.

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Hypertension as a Risk Factor for Heart Failure

Cited by 55 publications

References 67 publications

Analysis of carfilzomib cardiovascular safety profile across relapsed and/or refractory multiple myeloma clinical trials

Analysis of carfilzomib cardiovascular safety profile across relapsed and/or refractory multiple myeloma clinical trials

Cardiac inositol 1,4,5-trisphosphate receptors

Impacts of the Great East Japan Earthquake on diabetic patients

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