Hypertension as a paraneoplastic syndrome in hepatocellular carcinoma

Arai, Hajime; Saitoh, Shu‐ichi; Matsumoto, T; Makita, Fujio; Mitsugi, Sadanao; Yuasa, K.; Takagi, Hitoshi; Mori, Masataka

doi:10.1007/s005350050309

Cited by 21 publications

(16 citation statements)

References 9 publications

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“…Rare paraneoplastic syndromes, which can produce systemic hypertension, may be associated with hepatocarcinoma or renal malignancies, while it is usually alleged that more than half of patients with cancer will experience fever during the course of their disease [3]. The reasons for cancer-related fever are multiple but the most frequent and severe causes include opportunistic infections, venous thromboembolic disease or, more rarely, the fever is tumor-treatment related [4].…”

Section: Discussionmentioning

confidence: 99%

Paraneoplastic syndrome – unresponsive systemic hypertension and fever as expression of primitive ciliary body carcinoma in a blind painful eye: a case report

et al. 2016

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BackgroundThe purpose of this study was to present a case of paraneoplastic systemic hypertension and fever in an undiagnosed primary ciliary body carcinoma arising in a painful blind eye.Case presentationA 37-year-old white man with a history of blindness since childhood was enucleated for neovascular glaucoma because of intractable pain in his right eye. A histopathological examination revealed a ciliary body carcinoma. One year later, an invasive recurrence of his orbit and ethmoid was detected and a debulking procedure was performed. He had untreatable fever and multidrug-resistant systemic hypertension for 3 months before the neoplasm diagnosis. He recovered from fever and systemic hypertension only after tumor excision and relapsed 1 year later when synchronous tumor dissemination was shown through a computed tomography scan. Tumor metastases, despite surgery and chemotherapy, caused his death.ConclusionsParaneoplastic symptoms such as fever and hypertension may be due to unrecognized ocular malignancy. This case report intends to emphasize the importance of histopathological examination of an enucleated phthisical painful blind eye.

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Section: Discussionmentioning

confidence: 99%

Paraneoplastic syndrome – unresponsive systemic hypertension and fever as expression of primitive ciliary body carcinoma in a blind painful eye: a case report

et al. 2016

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“…This increase of plasma Ang-N levels is thought to be a major cause of the BP rise observed occasionally in women taking oral contraceptives [8,9]. Finally, many clinical observations and animal studies have consistently demonstrated a direct dependence of BP on plasma Ang-N levels [10][11][12]. Ang-N may therefore be an independent regulator of BP.…”

Section: Introductionmentioning

confidence: 94%

Blood pressure and renin–angiotensin system resetting in transgenic rats with elevated plasma Val5-angiotensinogen

Bohlender

Bäder²,

Ménard³

et al. 2012

Journal of Hypertension

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High plasma Ang-N increases plasma and kidney Ang-II levels, and amplifies the plasma and renal Ang-II response to a given change in renal renin secretion. This enzyme-kinetic amplification dominates over the Ang-II mediated feedback reduction of renin secretion. High Ang-N levels thus facilitate hypertension via small increases of Ang II and may influence the effectiveness of renin-angiotensin system inhibitors.

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“…Arterial hypertension has been described as a paraneoplastic manifestation of HCC. Some cases of severe arterial blood pressure associated with high plasma level of angiotensin-I, accompanied with hypokalemia have been reported [64]. Elevated concentrations of angiotensinogen have been found, whether or not associated with higher plasma levels of renin.…”

Section: Arterial Hypertensionmentioning

confidence: 99%