Hypertension artérielle associée à une paraparésie des membres inférieurs révélant un adénome surrénalien

Tabti, E.; Benmekki, Abdelghani; Bestaoui, M.H.; Messad, M.; Ghembaza, Amine; Lounici, A.

doi:10.1016/j.ancard.2018.05.001

Cited by 1 publication

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“…After chirurgical excision of the adrenal mass, our patient normalized his blood pressure with 3 years of follow up. This case illustrates a form of endocrine hypertension of adrenal origin and the need for a careful clinical examination during the discovery of hypertension in the young subject in order to carry out adequate balance sheets to search for a curable cause of secondary hypertension [1].…”

Section: Introductionmentioning

confidence: 99%

Adrenal Adenoma Causing Secondary Hypertension. A Review of the Literature

Lounici¹,

Tabti²,

Benmekki³

et al. 2018

JED

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Arterial hypertension (HTN) of endocrine origin accounts for 5 to 10% of cases of secondary hypertension. Although this form of hypertension is rare, the identification and treatment of the underlying cause could lead to healing or significant improvement in hypertension, thereby decreasing the cardiovascular risk and morbidity associated with hypertension. Endocrine causes of secondary hypertension are primary hyperaldosteronism, pheochromocytoma, Cushing's syndrome (CS), acromegaly, hyperparathyroidism, congenital adrenal hyperplasia, hypothyroidism, hyperthyroidism and secretory tumors of renin. The adrenal hypertension is the most frequent and the most frequently curable.Epidemiological data on hypertension associated with CS are largely retrospective. However, the available data suggested that 70-85% of adult patients with endogenous CS suffer from hypertension, compared to approximately 20% of patients long-term treated with exogenous corticosteroids.The mechanisms involved in the development of hypertension during CS are complex and only partially understood. The main data concerning the renin-angiotensin system, the mineral corticoid activity, the sympathetic nervous system and the vasoregulatory system, together with the indirect mechanisms, which contribute to the development of CS-related hypertension.The definitive therapy of CS-related hypertension is the surgical removal of the tumor responsible for the disease. Interestingly, mortality data show that adequate control of hypercortisolemia does not always lead to BP normalization. Some studies show a normalization of increased cardiovascular risk after immediate surgical cure of Cushing's disease, while others did not.The definitive therapy of CS-related hypertension is the surgical removal of the tumor responsible for the disease. Interestingly, mortality data show that adequate control of hypercortisolemia does not always lead to BP normalization. Some studies show a normalization of increased cardiovascular risk after immediate surgical cure of Cushing's disease [26], while others did not [27].

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Section: Introductionmentioning

confidence: 99%