Hypertension and Severe Hypokalemia Associated With Oral Ingestion of Topical Hydrocortisone Cream

Saha, A.; Balakrishnan, Suryanarayanan; Trivedi, Nitin; Abraham, George M.

doi:10.1016/j.aace.2022.10.004

Cited by 3 publications

(2 citation statements)

References 10 publications

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“…A promising strategy to prevent and treat ALI is to suppress the excessive production of inflammatory cytokines through anti-inflammatory drugs, including corticosteroids, such as methylprednisolone [10], dexamethasone (DEX) [11], prednisolone [12]. However, the clinical application of corticosteroids is usually accompanied by various severe side effects, such as hyperglycemia, hypertension, hypokalemia, dyslipidemia, osteoporosis, myopathy and immunosuppression [13][14][15]. Therefore, it is necessary to find new drugs with better efficacy and safety for the treatment of ALI patients.…”

Section: Introductionmentioning

confidence: 99%

Vitamin K2 (MK-7) attenuates LPS-induced acute lung injury via inhibiting inflammation, apoptosis, and ferroptosis

Wang,

Yang,

Liu

et al. 2023

PLoS ONE

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Acute lung injury (ALI) is a life-threatening disease that has received considerable critical attention in the field of intensive care. This study aimed to explore the role and mechanism of vitamin K2 (VK2) in ALI. Intraperitoneal injection of 7 mg/kg LPS was used to induce ALI in mice, and VK2 injection was intragastrically administered with the dose of 0.2 and 15 mg/kg. We found that VK2 improved the pulmonary pathology, reduced myeloperoxidase (MPO) activity and levels of TNF-α and IL-6, and boosted the level of IL-10 of mice with ALI. Moreover, VK2 played a significant part in apoptosis by downregulating and upregulating Caspase-3 and Bcl-2 expressions, respectively. As for further mechanism exploration, we found that VK2 inhibited P38 MAPK signaling. Our results also showed that VK2 inhibited ferroptosis, which manifested by reducing malondialdehyde (MDA) and iron levels, increasing glutathione (GSH) level, and upregulated and downregulated glutathione peroxidase 4 (GPX4) and heme oxygenase-1 (HO-1) expressions, respectively. In addition, VK2 also inhibited elastin degradation by reducing levels of uncarboxylated matrix Gla protein (uc-MGP) and desmosine (DES). Overall, VK2 robustly alleviated ALI by inhibiting LPS-induced inflammation, apoptosis, ferroptosis, and elastin degradation, making it a potential novel therapeutic candidate for ALI.

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Section: Introductionmentioning

confidence: 99%

Vitamin K2 (MK-7) attenuates LPS-induced acute lung injury via inhibiting inflammation, apoptosis, and ferroptosis

Wang,

Yang,

Liu

et al. 2023

PLoS ONE

View full text Add to dashboard Cite

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“…Under the Pituitary-Gonadal-Adrenal Access in this issue, a case¬†highlighted the risks associated with inappropriate use of over the counter medications such as hydrocortisone cream. 1 In another case, authors suggested the co-occurrence of both functional gonadotroph adenoma with a lactotroph adenoma in patients who present with elevated gonadotropin levels despite hyperprolactinemia. 2 …”

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confidence: 99%