Hypertension and reproductive dysfunction: a possible role of inflammation and inflammation-associated lymphangiogenesis in gonads

Navaneethabalakrishnan, Shobana; Goodlett, Bethany L; Lopez, Alexandra H; Rutkowski, Joseph M.; Mitchell, Brett M.

doi:10.1042/cs20201023

Cited by 10 publications

(7 citation statements)

References 195 publications

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“…N-nitrol-L-arginine methyl ester (L-NAME) is a vasoconstrictor, which is commonly used to induce the animal model of experimental hypertension ( 172 ), based on its inhibiting nitric oxide enzyme and consequently resulting in chronic NO depletion ( 173 ). Hypertension is a recognized risk factor for male reproductive dysfunction ( 174 , 175 ), such as erectile dysfunction ( 176 ), sperm quality impairment ( 177 ), penile and testicular morphology changes ( 178 ). Since L-NAME is non-toxic, reproductive defects including decreased T levels, decreased sperm motility, antioxidant status and histological changes of internal testicular artery ( 179 , 180 ) by L-NAME mainly attribute to hypertension in model animals.…”

Section: The Protective Effects Of Taurine Against Male Reproductive ...mentioning

confidence: 99%

The role of taurine in male reproduction: Physiology, pathology and toxicology

Peng²,

Shang³

et al. 2023

Front. Endocrinol.

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Taurine, a sulfur-containing amino acid, has a wide range of biological effects, such as bile salt formation, osmotic regulation, oxidative stress inhibition, immunomodulation and neuromodulation. Taurine has been proved to be synthesized and abundant in male reproductive organs. Recently, accumulating data showed that taurine has a potential protective effect on reproductive function of male animals. In physiology, taurine can promote the endocrine function of the hypothalamus-pituitary-testis (HPT) axis, testicular tissue development, spermatogenesis and maturation, delay the aging of testicular structure and function, maintain the homeostasis of the testicular environment, and enhance sexual ability. In pathology, taurine supplement may be beneficial to alleviate pathological damage of male reproductive system, including oxidative damage of sperm preservation in vitro, testicular reperfusion injury and diabetes -induced reproductive complications. In addition, taurine acts as a protective agent against toxic damage to the male reproductive system by exogenous substances (e.g., therapeutic drugs, environmental pollutants, radiation). Related mechanisms include reduced oxidative stress, increased antioxidant capacity, inhibited inflammation and apoptosis, restored the secretory activity of the HPT axis, reduced chromosomal variation, enhanced sperm mitochondrial energy metabolism, cell membrane stabilization effect, etc. Therefore, this article reviewed the protective effect of taurine on male reproductive function and its detailed mechanism, in order to provide reference for further research and clinical application.

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Section: The Protective Effects Of Taurine Against Male Reproductive ...mentioning

confidence: 99%

The role of taurine in male reproduction: Physiology, pathology and toxicology

Peng²,

Shang³

et al. 2023

Front. Endocrinol.

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“…However, the potential effect of metformin on ED via the third pathway is at least partly supported by our recent observational study that showed a significant risk reduction of hypertension (hazard ratio [HR], 0.724; 95% confidence interval [CI], 0.681–0.769) in patients with T2DM who had been treated with metformin in comparison to patients who had never been treated with metformin [ 5 ]. Because hypertension is a well-recognized risk factor of atherosclerotic diseases and ED [ 31 ], an improvement in arteriogenic ED resulting from a reduced risk of hypertension and atherosclerotic diseases associated with metformin use is probable.…”

Section: Men's Reproductive Healthmentioning

confidence: 99%

The Effect of Metformin on Male Reproductive Function and Prostate: An Updated Review

Tseng

2022

World J Mens Health

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Metformin is the first-line oral antidiabetic drug that shows multiple pleiotropic effects of anti-inflamation, anti-cancer, anti-aging, anti-microbia, anti-atherosclerosis, and immune modulation. Metformin's effects on men's related health are reviewed here, focusing on reproductive health under subtitles of erectile dysfunction (ED), steroidogenesis and spermatogenesis; and on prostate-related health under subtitles of prostate specific antigen (PSA), prostatitis, benign prostate hyperplasia (BPH), and prostate cancer (PCa). Updated literature suggests a potential role of metformin on arteriogenic ED but controversial and contradictory effects (either protective or harmful) on testicular functions of testosterone synthesis and spermatogenesis. With regards to prostate-related health, metformin use may be associated with lower levels of PSA in humans, but its clinical implications require more research. Although there is a lack of research on metform's effect on prostatitis, it may have potential benefits through its anti-microbial and anti-inflammatory properties. Metformin may reduce the risk of BPH by inhibiting the insulin-like growth factor 1 pathway and some but not all studies suggest a protective role of metformin on the risk of PCa. Many clinical trials are being conducted to investigate the use of metformin as an adjuvant therapy for PCa but results currently available are not conclusive. While some trials suggest a benefit in reducing the metastasis and recurrence of PCa, others do not show any benefit. More research works are warranted to illuminate the potential usefulness of metformin in the promotion of men's health.

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“…Hypertension is a common chronic disease encountered in clinical practice. Based on the related complications, the mortality and disability rate are at the forefront of human diseases, which causes great harm to human health ( Wang et al, 2014 ; Navaneethabalakrishnan et al, 2020 ). At present, most blood pressure-lowering drugs in clinical use are chemically synthesized.…”

Section: Introductionmentioning

confidence: 99%

Study on the vasodilatory activity of lotus leaf extract and its representative substance nuciferine on thoracic aorta in rats

Deng

Sang

et al. 2022

Front. Pharmacol.

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Lotus (Nelumbo nucifera) leaves are widely used for both edible and medicinal applications. For its further utilization, we studied the vasodilatory activity of lotus leaf extract for the first time. In this study, we obtained the extracts using different ratios of water and ethanol, which was followed by polarity-dependent extraction. We found that the CH2Cl2 layer exhibited better vasodilatory activity (EC50 = 1.21 ± 0.10 μg/ml). HPLC and ESI-HRMS analysis of the CH2Cl2 layer using the standard product as a control revealed that nuciferine (Emax = 97.95 ± 0.76%, EC50 = 0.36 ± 0.02 μM) was the main component in this layer. Further research revealed that nuciferine exerts a multi-target synergistic effect to promote vasodilation, via the NO signaling pathway, K+ channel, Ca2+ channel, intracellular Ca2+ release, α and β receptors, etc. Nuciferine exhibits good vasodilatory activity, and it exhibits the potential to be utilized as a lead compound.

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Hypertension and reproductive dysfunction: a possible role of inflammation and inflammation-associated lymphangiogenesis in gonads

Cited by 10 publications

References 195 publications

The role of taurine in male reproduction: Physiology, pathology and toxicology

The role of taurine in male reproduction: Physiology, pathology and toxicology

The Effect of Metformin on Male Reproductive Function and Prostate: An Updated Review

Study on the vasodilatory activity of lotus leaf extract and its representative substance nuciferine on thoracic aorta in rats

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