Hypertension and Renin-Angiotensin System Blockers Are Not Associated With Expression of Angiotensin Converting Enzyme 2 (Ace2) in the Kidney

Jiang, Xiao; Eales, James; Scannali, David; Nazgiewicz, Alicja; Prestes, Priscilla; Maier, Michelle; Denniff, Matthew; Xu, Xiaoguang; Saluja, Sushant; Wystrychowski, Wojciech; Żywiec, Joanna; Żukowska-Szczechowska, E; Burrell, Louise M.; Greenstein, Adam; Bogdański, Paweł; Keavney, Bernard; Morris, Adrew P.; Heagerty, Anthony M.; Samani, Nilesh J.; Guzik, Tomasz J.; Charchar, Fadi J.; Tomaszewski, Maciej

doi:10.1097/01.hjh.0000744740.07122.70

Cited by 6 publications

(11 citation statements)

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“…Those most vulnerable may have also avoided pharmacies for picking up antihypertensive medications, leading to discontinuation of treatment. Thirdly, the suspicions that certain antihypertensive medications (i.e., ACE-inhibitors and angiotensin receptor blockers) may increase susceptibility to infection, may have led to a drop in adherence to these medications amongst patients with hypertension [98]. The effects of the pandemic on un-employment and subsequent drop in income (even in the developed economies) are likely to have augmented already high rates of cost-related medication nonadherence [99].…”

Section: Assessing and Maintaining Adherence Virtuallymentioning

confidence: 99%

Virtual management of hypertension: lessons from the COVID-19 pandemic–International Society of Hypertension position paper endorsed by the World Hypertension League and European Society of Hypertension

Khan

Stergiou

Omboni

et al. 2022

Journal of Hypertension

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The coronavirus disease 2019 pandemic caused an unprecedented shift from in person care to delivering healthcare remotely. To limit infectious spread, patients and providers rapidly adopted distant evaluation with online or telephone-based diagnosis and management of hypertension.It is likely that virtual care of chronic diseases including hypertension will continue in some form into the future. The purpose of the International Society of Hypertension's (ISH) position paper is to provide practical guidance on the virtual management of hypertension to improve its diagnosis and blood pressure control based on the currently available evidence and international experts’ opinion for nonpregnant adults. Virtual care represents the provision of healthcare services at a distance with communication conducted between healthcare providers, healthcare users and their circle of care. This statement provides consensus guidance on: selecting blood pressure monitoring devices, accurate home blood pressure assessments, delivering patient education virtually, health behavior modification, medication adjustment and long-term virtual monitoring. We further provide recommendations on modalities for the virtual assessment and management of hypertension across the spectrum of resource availability and patient ability.

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Section: Assessing and Maintaining Adherence Virtuallymentioning

confidence: 99%

Virtual management of hypertension: lessons from the COVID-19 pandemic–International Society of Hypertension position paper endorsed by the World Hypertension League and European Society of Hypertension

Khan

Stergiou

Omboni

et al. 2022

Journal of Hypertension

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“…The question seemed to be a sensible one. The study of Jiang et al 11 confirmed that an older age favours the SARS-CoV-2 infection process by upregulating ACE2. A possible explanation being that RASIs could counterbalance this process through alteration of the cell surface interaction mechanism between this receptor and the angiotensin receptor type one.…”

Section: Does Age Modify the Effect Of Rasis?mentioning

confidence: 86%

“…Jiang et al 11 find no evidence of RASIs upregulating ACE2, based on a sample of RNA-sequenced kidney transcriptomes, which significantly mitigates fears of a possible harmful RASI effect in Covid-19. The authors find kidney expression of ACE2 to increase with age but not as an effect of RASI exposure.…”

Section: Transcriptomics Studymentioning

confidence: 98%

Hunting for protective drugs at the break of a pandemic: Causal inference from hospital data

Berzuini

Bernardinelli

2022

Stat Methods Med Res

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At the break of a pandemic, the protective efficacy of therapeutic interventions needs rapid evaluation. An experimental approach to the problem will not always be appropriate. An alternative route are observational studies, whether based on regional health service data or hospital records. In this paper, we discuss the use of methods of causal inference for the analysis of such data, with special reference to causal questions that may arise in a pandemic. We apply the methods by using the aid of a directed acyclic graph (DAG) representation of the problem, to encode our causal assumptions and to logically connect the scientific questions. We illustrate the usefulness of DAGs in the context of a controversy over the effects of renin aldosterone system inhibitors (RASIs) in hypertensive individuals at risk of (or affected by) severe acute respiratory syndrome coronavirus 2 disease. We consider questions concerning the existence and the directions of those effects, their underlying mechanisms, and the possible dependence of the effects on context variables. This paper describes the cognitive steps that led to a DAG representation of the problem, based on background knowledge and evidence from past studies, and the use of the DAG to analyze our hospital data and assess the interpretive limits of the results. Our study contributed to subverting early opinions about RASIs, by suggesting that these drugs may indeed protect the older hypertensive Covid-19 patients from the consequences of the disease. Mechanistic interaction methods revealed that the benefit may be greater (in a sense to be made clear) in the older stratum of the population.

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“…Другие недавние исследования подтвердили эти наблюдения, сообщив, что возраст старше 60 лет, избыточный вес / ожирение и СД, но ни АГ, ни антигипертензивное лечение не были связаны с неблагоприятным прогнозом [9,10].…”

Section: ____________________________________________________________...unclassified

“…Небольшое исследование [15] показало, что макрофаги и нейтрофилы пациентов с АГ с COVID-19 демонстрируют более высокую экспрессию провоспалительных хемокинов, таких как лиганды хемокинов с двумя соседними цистеинами (CCL3, CCL4) и рецептор хемокинов CCR1. Недавнее исследование [16] показало связанное с возрастом увеличение экспрессии ангиотензинпревращающего фермента 2 (АПФ2) в тканях почек и легких человека и отсутствие связи между АГ, блокаторами ренин-ангиотензиновой системы (РАС) и почечной экспрессией АПФ2 [17]. Эти результаты согласуются с предыдущими отчетами, предполагающими, что использование блокаторов РАС не было связано с более высокой экспрессией AПФ2 в тканях легких, а также с увеличением концентрации AПФ2 в циркулирующей плазме [18,19].…”

Section: ____________________________________________________________...unclassified

The Importance of Cardiometabolic Risk Factors During the COVID-19 Pandemic: Review of the Сonsensus Paper from the European Society of Cardiology

Суджаева¹

2022

Рецепт

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В настоящей статье приведен обзор опубликованного в 2021 г. согласованного мнения экспертов Рабочей группы Европейского общества кардиологов по коронарной патофизиологии и микроциркуляции, Рабочей группы ESC по тромбозам и Ассоциации неотложной сердечно-сосудистой помощи в сотрудничестве с Европейской ассоциацией сердечного ритма, посвященного сердечно-сосудистым заболеваниям при коронавирусной болезни-19 (COVID-19). Суммированы наиболее актуальные данные о патогенезе повреждающего действия коронавируса-2, вызывающего тяжелый острый респираторный синдром (SARS-CoV-2), на сердце и сосуды. Отдельно рассмотрена роль кардиометаболических факторов риска (артериальная гипертензия, нарушения углеводного обмена, ожирение и курение) в период пандемии COVID-19.

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Hypertension and Renin-Angiotensin System Blockers Are Not Associated With Expression of Angiotensin Converting Enzyme 2 (Ace2) in the Kidney

Cited by 6 publications

References 0 publications

Virtual management of hypertension: lessons from the COVID-19 pandemic–International Society of Hypertension position paper endorsed by the World Hypertension League and European Society of Hypertension

Virtual management of hypertension: lessons from the COVID-19 pandemic–International Society of Hypertension position paper endorsed by the World Hypertension League and European Society of Hypertension

Hunting for protective drugs at the break of a pandemic: Causal inference from hospital data

The Importance of Cardiometabolic Risk Factors During the COVID-19 Pandemic: Review of the Сonsensus Paper from the European Society of Cardiology

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