Hypertension and Plasma Renin Activity in Experimentally Induced Chronic Pyelonephritis

Tsuchida, Seigi; Yamaguchi, Osamu; Miura, Kouji; Miyagawa, Ikuo; Kumagai, Ikutaro

doi:10.5980/jpnjurol1928.66.4_188

Cited by 3 publications

(4 citation statements)

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“…Inflammation and blood pressure Tsutida et al (1975) reported that a slight elevation of resting PRA was transiently found within 3 to 4 days of the acute stage of chronic pyelonephritis in rats, but it was not accompanied by hypertension . He did not examine the relationship between resting PRA and sodium balance .…”

Section: Resultsmentioning

confidence: 99%

Elevated Plasma Renin Activity in Patients with Acute Pyelonephritis

Kuroda

Matsumoto

Haruyama

et al. 1978

Tohoku J. Exp. Med.

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Section: Resultsmentioning

confidence: 99%

Elevated Plasma Renin Activity in Patients with Acute Pyelonephritis

Kuroda

Matsumoto

Haruyama

et al. 1978

Tohoku J. Exp. Med.

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“…1971). We previously conducted animal experiments in which non-obstructive pyelonephritis was produced in dogs , and plasma renin activity was observed in relation to blood pressure (Tsuchida et al 1975). Renin activity, except in the acute stage of the disease , tended to become suppressed despite the general rise in blood pressure .…”

Section: Discussionmentioning

confidence: 99%

Pyelonephritis and Hypertension

Tsuchida

Miura

Yamaguchi

et al. 1975

Tohoku J. Exp. Med.

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Blood pressure changes were followed up for 1-12 years (average; 3.8 years) in 46 cases of confirmed postoperative chronic pyelonephritis which had undergone ureterocutaneostomy, nephrostomy or other urologic operations.Diastolic blood pressure levels averaged 82 mmHg before operation, and 89 mmHg in the chronic stage after the operation. The incidence of hypertension (over 100 mmHg diastolic pressure) was 7% before the operation, but rose to 30% in the chronic stage. Application of an "age and sex-adjusted score" also served to confirm a mean increase in blood pressure through the development of chronic pyelonephritis.No correlation was found between renal function and blood pressure.Nor was there any definite relationship between family history of hypertension and high blood pressure.In the 14 cases observed for plasma renin activity, values were found to be in the normal range.pyelonephritis; hypertension; postoperative hypertensionThe relationship between chronic pyelonephritis and hypertension has been widely studied since it was first pointed out by Longcope (1937). There remains a problem, however, as to the cause-and-effect relationship between the two diseases. This may be because blood pressure has been observed in cases of pyelonephritis only after the onset of the chronic stage, and without reference to pre-disease levels. Further, when observations were made over a long period of time, age-related rises in blood pressure may over-lap. A comparative study of blood pressure levels before and after the development of pyelonephritis should help to clarify the relationship between the two diseases.We examined 46 patients who had developed chronic non-obstructive pyelone phritis after undergone urologic operation. Controls were provided by blood pressure measurements in other urological cases free from pyelonephritis and renovascular hypertension. For the cases of chronic pyelonephritis the relationships between blood pressure and renal function, and between blood pressure and genetic factor were also assessed. In 14 of these cases plasma renin activity was also studied in related to blood pressure.

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“…Females appear to pre dominate over males by 5 or 10 to 1 in small series. Patho logically, the affected portions of the kidneys are charac terized by thick-walled smaller arteries, small scattered dilated tubules, a reduced number of glomeruli, and few, if any, inflammatory or round cell infiltrates [15,17,18], Few studies of the renin system have been reported. The renal venous D/N ratio was above 1.5 in 2 [17,19] and below 1.5 in a 3rd patient [18], In I patient with an abnormal D/N ratio, the peripheral renin activity was normal and the sarileu-sin test was negative [19].…”

Section: Congenita] Hypoplasiamentioning

confidence: 99%

“…Tsuchida et al [15] produced unilateral pyelonephritis in dogs by vesicoureteral reflux combined with ascending infection. The blood pressure increased in 21 of 23 animals without measurable change in plasma renin activity.…”

Section: Chronic Atrophic Pyelonephritis -Including Pyenephrosis and mentioning

confidence: 99%

Unilateral Renal Disease and Hypertension

Wesson¹

1982

Nephron

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Hypertension and Plasma Renin Activity in Experimentally Induced Chronic Pyelonephritis

Cited by 3 publications

References 0 publications

Elevated Plasma Renin Activity in Patients with Acute Pyelonephritis

Elevated Plasma Renin Activity in Patients with Acute Pyelonephritis

Pyelonephritis and Hypertension

Unilateral Renal Disease and Hypertension

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