Hypertension and peripheral arterial disease

Bennett, Philip C.; Silverman, Stanley; Gill, Paramjit

doi:10.1038/jhh.2008.126

Cited by 20 publications

(15 citation statements)

References 23 publications

(27 reference statements)

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“…Indeed, pathophysiological and epidemiological links between AH and vasculopathy have been well established [21]; however, multivariate analysis showed that in our study population vasculopathy was not independently associated to HCs. In the big, multicenter "STAT" registry study on acute hypertension treatment the prevalence of vasculopathy or CAD was of 11 % and 5 %, respectively [22].…”

Section: Discussioncontrasting

confidence: 70%

Incidence, Associated Clinical Factors and Outcome of Hypertensive Crises in Critically Ill Patients: A Prospective Survey

Chelazzi¹,

Villa²,

Margiacchi³

et al. 2011

J Anesthe Clinic Res

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Background: Hypertensive crises (HCs) are common among critically ill patients. However, little is known of their epidemiology, particularly actual rate and outcome of affected patients. Primary end-point of the study was to assess incidence of and clinical factors associated with HCs in a cohort of patients admitted to a general ICU. Secondary end-point was to assess the impact of HC on patients' outcome.Methods: All patients consecutively admitted to a general ICU over a 13 months period were included in the study. Incidence of HCs was assessed and associated clinical factors were determined using univariate and multivariate analysis. Length-of-stay and ICU-and in-hospital mortality were evaluated.Results: Incidence of HCs was 15.4%. Factors independently associated with HCs were: ICU-admission for acute medical conditions, cigarette smoking, cancer, coronary artery disease, chronic atrial fibrillation (p<0.05). ICU length-of-stay and ICU-/ in-hospital mortality rate were higher among patients with HCs (p<0.05). Conclusion:HCs are common in critically ill patients, even if previously normotensive, and are associated with a worse outcome. Associated clinical factors include acute medical conditions leading to ICU admission, cigarette smoking, cancer, coronary artery disease and chronic atrial fibrillation.

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Section: Discussioncontrasting

confidence: 70%

Incidence, Associated Clinical Factors and Outcome of Hypertensive Crises in Critically Ill Patients: A Prospective Survey

Chelazzi¹,

Villa²,

Margiacchi³

et al. 2011

J Anesthe Clinic Res

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“…For instance, HT,9) DM,10) hypercholesterolemia,11) smoking,12) CKD,13) and MetS4) are known risk factors for CAD. Furthermore, HT,14) DM,15) hypercholesterolemia,16) smoking,17) CKD,5) and MetS4) are risk factors for PAD. In our study, the mean TC, LDL-C, HDL-C values were higher in the normal control group than those in the PAD or CAD group.…”

Section: Discussionmentioning

confidence: 99%

Comparison of Cardiovascular Risk Factors for Peripheral Artery Disease and Coronary Artery Disease in the Korean Population

Jang

Cho

et al. 2013

Korean Circ J

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Background and ObjectivesThe objective of this study was to analyze and compare risk factors for peripheral artery disease (PAD) and coronary artery disease (CAD).Subjects and MethodsThe sample included 7936 Korean patients aged ≥20 years who were hospitalized from 1994 to 2004. Of the 7936 subjects, PAD (n=415), CAD (n=3686), and normal controls (Control) (n=3835) were examined at the Health Promotion Center, Samsung Medical Center.ResultsThe mean age (years) of PAD subjects was 64.4 (±9.3), while CAD subjects was 61.2 (±9.9), and Control subjects was 59.9 (±9.1) (p<0.01). The proportion of males was 90.6% for PAD, 71.4% for CAD, and 75.5% for Control subjects (p<0.01). The adjusted odds ratios (ORs) for hypertension, diabetes mellitus, hypercholesterolemia, smoking, metabolic syndrome and chronic kidney disease were significantly higher in subjects with PAD or CAD compared to those in Control. However, the ORs for high density lipoprotein, being overweight, and being obese were significantly lower in PAD subjects compared to those in Control.ConclusionWe found that cardiovascular risk factors were in fact risk factors for both PAD and CAD.

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“…Although the association of PAD with higher risk of ischemic events has been identified, this particular manifestation of systemic atherosclerosis is largely under diagnosed and undertreated [2, 3]. The main systemic atherosclerotic vascular diseases, namely coronary artery disease (CAD), cerebrovascular disease (CVD) and PAD are leading causes of morbidity and mortality and all these diseases share the common pathophysiological process of atherothrombosis [4]. …”

Section: Introductionmentioning

confidence: 99%

Risk factors of peripheral arterial disease: a case control study in Sri Lanka

et al. 2016

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BackgroundPeripheral artery disease (PAD) is an important global health problem and contributes to notable proportion of morbidity and mortality. This particular manifestation of systemic atherosclerosis is largely under diagnosed and undertreated. For sustainable preventive strategies in a country, it is mandatory to identify country-specific risk factors. We intended to assess the risk factors of PAD among adults aged 40–74 years.MethodsThis case control study was conducted in 2012–2013 in Sri Lanka. Seventy-nine cases and 158 controls in the age group of 40–74 years were selected for the study in order to have case to control ratio 1:2. The criterion for selecting cases and control was based on Ankle brachial pressure index (ABPI). Cases were selected from those who had ABPI 0.85 or less (ABPI ≤0.85) in either lower limb. Controls were selected from those ABPI score between 1.18 and 1.28 in both lower limbs. Only newly identified individuals with PAD were selected as cases. Controls were selected from the same geographical location and within the 5 year age group as cases.ResultsThe history of diabetes mellitus more than 10 years (OR 5.8, 95% CI 2.2–14.2), history of dyslipidemia for more than 10 years (OR 4.9, 95% CI 2.1–16.2), history of hypertension for more than 10 years (OR 3.8, 95% CI 1.8–12.7) and smoking (OR 2.9, 95% CI 1.2–6.9), elevated HsCRP (OR 3.7, 95% CI 1.2–12.0) and hyperhomocysteinemia (OR 3.0, 95% CI 1.1–8.1) were revealed as country specific significant risk factor of PAD.ConclusionsDiabetes mellitus, hypertension, dyslipidemia, smoking as well as elevated homocysteine and HsCRP found as risk factors of PAD. Longer the duration or higher level exposure to these risk factors has increased the risk of PAD. These findings emphasis the need for routine screening of PAD among patients with the identified risk factors.

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Hypertension and peripheral arterial disease

Cited by 20 publications

References 23 publications

Incidence, Associated Clinical Factors and Outcome of Hypertensive Crises in Critically Ill Patients: A Prospective Survey

Incidence, Associated Clinical Factors and Outcome of Hypertensive Crises in Critically Ill Patients: A Prospective Survey

Comparison of Cardiovascular Risk Factors for Peripheral Artery Disease and Coronary Artery Disease in the Korean Population

Risk factors of peripheral arterial disease: a case control study in Sri Lanka

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