Hypertension and Male Fertility

Guo, David; Li, Shufeng; Behr, Barry; Eisenberg, Michael L.

doi:10.5534/wjmh.2017.35.2.59

Cited by 59 publications

(46 citation statements)

References 30 publications

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“…We Consistent with previous findings in Nigeria [15] and elsewhere [16], our results suggest that systolic and diastolic hypertension are prevalent among men with fertility challenge. Among sub-fertile men, only about 23% professionals reported high frequency of MESI (16 -20) compared to about 54% of entrepreneurs while no sub-fertile man who commonly drinks reported high frequency of MESI.…”

Section: Discussionsupporting

confidence: 93%

Frequency of Monthly Ejaculation at Sexual Intercourse, DNA Fragmentation Index and Fertilization Rate among Sperm Donors and Fertility-Challenged Men in Sub-Saharan Africa: Paper 1

Ajayi¹,

Afolabi²,

Ajayi³

et al. 2019

OJU

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Introduction: In humans, the ideal ejaculation frequency depends on age, exercise and sexual potential. Natural ejaculation frequency balances the testosterone levels in the body. Materials and Methods: Semi-structured questionnaire was used to collect information from subjects. Semen samples were collected from sperm donors and sub-fertile men who presented for infertility challenges. Processing and analysis of semen samples were done according to World Health Organization guidelines. Sperm DNA fragmentation was evaluated using the Halosperm® kit. Results: A total of 114 subjects, including 19 sperm donors and 95 sub-fertile males were studied. There was a significant difference (t = −5.96, P-value = 0.00001) in the mean [±sd] age of sperm donors (30.8 [8.1]) and that of sub-fertile men (42.3 [76]). There was a significant difference (t= −4.10, P-value = 0.0005) in the mean monthly ejaculation during sexual intercourse (MESI) among sperm donors with DNA fragmentation index < 25% (3.0 [1.0]) compared to those with DNA fragmentation index ≥ 25% (9.3 [5.5]). There was also a significant difference (t= −2.20, P-value = 0.02) in MESI among sub-fertile men aged ≥40 years (8.9 [4.6]) than among those aged <40 years (10.8 [3.8]). Entrepreneurs (59.3%) and non-smokers (84.6%) reported higher frequency (16-20) of MESI than others. There was a significant but negative correlation between frequency of MESI and DNA fragmentation index category (coef.

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Section: Discussionsupporting

confidence: 93%

Frequency of Monthly Ejaculation at Sexual Intercourse, DNA Fragmentation Index and Fertilization Rate among Sperm Donors and Fertility-Challenged Men in Sub-Saharan Africa: Paper 1

Ajayi¹,

Afolabi²,

Ajayi³

et al. 2019

OJU

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“…Previous studies have indicated that BP is inversely associated with serum total testosterone, free testosterone, and SHBG . A recent study showed a significant relationship between HTN and impaired semen quality in men diagnosed with HTN: They had a lower semen volume, sperm motility, and total sperm count compared to the normal group . Both clinical and experimental evidence indicates that humans or animals with DM exhibited altered sperm parameters .…”

Section: Discussionmentioning

confidence: 99%

“…32,33 A recent study showed a significant relationship between HTN and impaired semen quality in men diagnosed with HTN: They had a lower semen volume, sperm motility, and total sperm count compared to the normal group. 34 Both clinical and experimental evidence indicates that humans or animals with DM exhibited altered sperm parameters. 35 Numerous studies report that DM reduces serum testosterone levels, contributing to a steroidogenetic defect in Leydig cells.…”

Section: Discussionmentioning

confidence: 99%

Metabolic syndrome and semen quality in adult population

Chen

Kao

Peng

et al. 2019

Journal of Diabetes

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Background Male obesity is suggested to impact negatively on male fertility and semen quality in numerous studies. However, previous literatures regarding health effects of the metabolic syndrome (MetS) on semen quality are rare and inconsistent. The aim of this study is to investigate the relationship between MetS and sperm parameters in a Taiwanese reproductive‐age male population. Methods A total of 8395 men who attended a private medical screening program in Taiwan from 2010 to 2016 were included in this cross‐sectional study. Semen analysis was assessed in accordance with the WHO guidelines and included sperm concentration, total motility, progressive motility, and morphology. MetS was defined by the modified National Cholesterol Education Program Third Adult Treatment Panel (NCEP ATP III) criteria with the Asian cutoff for waist circumference (WC). The associations between MetS and semen analysis were examined by multivariable linear regressions. Results After fully adjusting for pertinent covariables, MetS was significantly associated with a reduced percentage of sperm normal morphology. Blood pressure, WC, and serum glucose had a significantly negative association with sperm normal morphology. Individuals with an increased number of MetS components had a closer association with reduced sperm progressive motility and the percentage of normal morphology. Conclusion MetS and its components exhibited deleterious effects on semen quality among reproductive‐age men. Further studies are warranted to explore these pathophysiologic relationship and underlying mechanisms.

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“…About 15% of all couples are infertile, and it is estimated that a male factor plays a role in about half of the cases . Recent data suggest that men with male factor infertility (MFI) may have a lower general health status, with a higher risk of developing tumours and age‐related diseases, such as cardio‐vascular and metabolic disorders . In this context, various studies have focused on the association between male infertility and impaired glucose metabolism .…”

Section: Introductionmentioning

confidence: 99%

Undiagnosed prediabetes is highly prevalent in primary infertile men – results from a cross‐sectional study

et al. 2018

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ObjectiveTo study the prevalence and the risk associated with prediabetes (PreDM) in primary infertile men. Patients and methodsData from 744 infertile men were analysed. Healthsignificant comorbidities were scored with the Charlson Comorbidity Index (CCI). Serum hormones were measured in every man. Semen analysis was based on 2010 World Health Organization (WHO) reference criteria. PreDM was defined according to the clinical criteria detailed by the American Diabetes Association (Diabetes Care 2014; 37 (Suppl. 1): S81). Descriptive statistics and logistic regression analyses tested the association between PreDM status, hormonal milieu and seminal parameters. The predictive accuracy of all variables was evaluated using the area under the curve, and the clinical net benefit estimated by decision curve analysis (DCA). ResultsOf the 744 men, PreDM was found in 114 (15.4%). Men with PreDM (+PreDM) were older, had higher CCI scores, lower total testosterone and sex hormone-binding globulin but higher follicle-stimulating hormone (FSH) and 17b-oestradiol values compared to those without PreDM (ÀPreDM) (all P ≤ 0.04). Higher sperm DNA fragmentation index (DFI; P = 0.014) and idiopathic non-obstructive azoospermia (iNOA; P < 0.001) were found more frequently in +PreDM men. At multivariable logistic regression analysis, older age, FSH and iNOA (all P ≤ 0.04) were significantly associated with +PreDM status. DCA demonstrated a clinical net benefit in discriminating men at higher risk of a +PreDM status. ConclusionsAbout 15% of primary infertile men had criteria suggestive of undiagnosed PreDM. A PreDM status was associated with a greater risk of hypogonadism, higher DFI values and iNOA status. Age, FSH values and iNOA status could be considered as useful parameters to recognise men with PreDM and implement early preventive interventions in those men at risk of the consequences from poor glycaemic control.

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Hypertension and Male Fertility

Cited by 59 publications

References 30 publications

Frequency of Monthly Ejaculation at Sexual Intercourse, DNA Fragmentation Index and Fertilization Rate among Sperm Donors and Fertility-Challenged Men in Sub-Saharan Africa: Paper 1

Frequency of Monthly Ejaculation at Sexual Intercourse, DNA Fragmentation Index and Fertilization Rate among Sperm Donors and Fertility-Challenged Men in Sub-Saharan Africa: Paper 1

Metabolic syndrome and semen quality in adult population

Undiagnosed prediabetes is highly prevalent in primary infertile men – results from a cross‐sectional study

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