Hypertension and hypothyroidism: results from an ambulatory blood pressure monitoring study

“…The analyses were exploratory, and findings should be confirmed for subjects in different districts and for different populations of subjects. In addition, the observed indicators in our study were relationships between thyroid function and clinic blood pressure, others studies had shown both overt and subclinical hypothyroidism were not only associated with the clinic blood pressure but also related to ambulatory blood pressure [28][29][30]. To the best of our knowledge, few studies have been performed to examine the relationship of blood pressure to thyroid function in children and adolescents.…”

Section: Discussionmentioning

confidence: 38%

Investigation of thyroid function and blood pressure in school-aged subjects without overt thyroid disease

Chen

Zhang

et al. 2011

Endocrine

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This study was performed to ascertain whether a relationship exists between thyroid function and blood pressure in school-aged Chinese subjects without overt thyroid disease. A cross-sectional survey of 880 subjects (541 females and 339 males) aged 7-18 years in Bengbu, Anhui province was conducted. The investigation, which was based on a stratified random cluster sampling method, included a questionnaire and measurements of blood pressure, height, and body weight. Fasting blood samples were taken for measurements of thyroid-stimulating hormone (TSH), free 3,5,3'-triiodothyronine (FT(3)) and free thyroxine (FT(4)). Serum TSH and FT(3) were positively correlated with systolic and diastolic blood pressure Z scores (SBP-Z and DBP-Z) even after adjusting for body mass index (BMI) (P < 0.05) but no correlation was observed between FT(4) and SBP-Z or DBP-Z after comparable adjustments (P > 0.05). SBP-Z and DBP-Z in subjects with subclinical hypothyroidism were significant higher than in euthyroid subjects (P < 0.05). Both SBP-Z and DBP-Z increased linearly with TSH concentration in boys after adjusting BMI (P < 0.05); however, a similar linear trend was not observed in girls. Our findings support the hypothesis that elevated TSH and FT(3) concentrations increase blood pressure in school-aged Chinese subjects without overt thyroid disease; this increase may be even more significant in boys.

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“…Previous studies differ in their results about cardiovascular aspects of SH, since many of them had diverse variable definitions of disease states and inclusion criteria. Hypothyroidism may be a predictor of higher cardiovascular target-organ damage, as it has been associated with higher mean 24-h systolic blood pressure, 24-h pulse pressure and 24-h systolic blood pressure variability 21 . A recent study demonstrated that non-dipper hypertensive patients had lower serum FT3 levels than dipper patients and that FT3 was an independent predictor of non-dipper hypertension.…”

Section: Discussionmentioning

confidence: 99%