Hypertension and chronic kidney disease in Asian populations

Teo, Boon Wee; Chan, Gek Cher; Leo, Christopher Cheang Han; Tay, Jam Chin; Chia, Yook Chin; Siddique, Saulat; Turana, Yuda; Chen, Chen Huan; Hoshide, Satoshi; Minh, Huynh Van; Sogunuru, Guru Prasad; Wang, Tzung‐Dau

doi:10.1111/jch.14188

Cited by 17 publications

(16 citation statements)

References 31 publications

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“…A large number of studies have shown that the degree of portal hypertension is an important prognostic factor for liver dysfunction. , Additionally, necrotizing inflammation of the liver can promote the increase of hepatic vascular tension . At the same time, hypertension is also the main cause of chronic kidney disease . Retrospective analysis showed that the level of serum uric acid was negatively correlated with renal function.…”

Section: Introductionmentioning

confidence: 99%

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Metabolomics of Artichoke Bud Extract in Spontaneously Hypertensive Rats

Wang

Jiang

Liu³

et al. 2021

ACS Omega

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Hypertension adversely affects the quality of life in humans across modern society. Studies have attributed increased reactive oxygen species production to the pathophysiology of hypertension. So far, a specific drug to control the disease perfectly has not been developed. However, artichoke, an edible vegetable, plays an essential role in treating many diseases due to its potent antioxidant activities. The objective of this study is to evaluate the effect of artichoke bud extract (ABE) on heart tissue metabolomics of hypertensive rats. Spontaneously hypertensive rats and Wistar–Kyoto (WKY) rats were divided into six groups, then exposed to different doses comprising ABE, Enalapril Maleate, or 1% carboxylmethyl cellulose for 4 weeks. Their blood pressures were recorded at 0, 2, 3, and 4 weeks after the start of the test period. Thereafter, all rats were anesthetized, and blood was collected from their cardiac apexes. Then, we measured the levels for 15 kinds of serum biochemical parameters. An established orthogonal partial least square-discriminant analysis model completed the metabolomic analysis. Hypertensive rats in the ABE group exhibited well-controlled blood pressure, relative to those in the model group. Specifically, artichoke significantly lowered serum levels for total protein (TP), albumin (ALB), and uric acid (UA) in the hypertensive rats. This effect involved the action of eight metabolites, including guanine, 1-methylnicotinamide, p-aminobenzoic acid, NAD, NADH, uridine 5′-monophosphate, adenosine monophosphate, and methylmalonic acid. Collectively, these findings suggest that ABE may play a role in affecting oxidative stress and purine, nicotinate, and nicotinamide metabolism.

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Section: Introductionmentioning

confidence: 99%

“…10 At the same time, hypertension is also the main cause of chronic kidney disease. 11 Retrospective analysis showed that the level of serum uric acid was negatively correlated with renal function. The level of serum uric acid is directly related to SP and DP.…”

Section: Introductionmentioning

confidence: 99%

Metabolomics of Artichoke Bud Extract in Spontaneously Hypertensive Rats

Wang

Jiang

Liu³

et al. 2021

ACS Omega

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“…Forthly, secondary hypertension and dyslipidemia, and genetic familial hypercholesterolemia were not excluded in this study, if any. Finally, the contents of pharmacotherapy for hypertension, which can influence the metabolism of lipids [ 44 , 45 ], the data of renal function and serum uric acid, which contribute to the development of hypertension [ 46 , 47 , 48 , 49 ], and the data of diet were also unavailable in this study. Further studies addressing these limitations are needed to warrant current results.…”

Section: Resultsmentioning

confidence: 99%

Association of Serum High-Density Lipoprotein Cholesterol with High Blood Pressures at Checkup: Results of Kanagawa Investigation of Total Checkup Data from the National Database-9 (KITCHEN-9)

Nakajima

Igata

Higuchi

et al. 2021

JCM

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Background: although high-density lipoprotein has cardioprotective effects, the association between serum high-density lipoprotein cholesterol (HDL-C) and hypertension is poorly understood. Therefore, we investigated whether high and low concentrations of HDL-C are associated with high blood pressure (HBP) using a large healthcare dataset. Methods: in a community-based cross-sectional study of 1,493,152 Japanese people (830,669 men and 662,483 women) aged 40–74 years who underwent a health checkup, blood pressures automatically measured at healthcare center were investigated in nine HDL-C groups (20–110 mg/dL or over). Results: crude U-shaped relationship were observed between the nine HDL-C and blood pressures in both men and women. Logistic regression analysis showed left-to-right inverted J-shaped relationships between HDL-C and odds ratios for HBP (≥140/90 mmHg and/or pharmacotherapy), with lower limits of 90–99 mg/dL in both sexes, which were unchanged after adjusting for confounding factors. However, further adjustment for body mass index and serum triglyceride concentration revealed positive linear associations between HDL-C and HBP, although blunt U-shaped associations remained in nonalcohol drinkers. Conclusion: both low and extremely high HDL-C concentrations are associated with HBP. The former association might be dependent on excess fat mass concomitant with low HDL-C, whereas the latter association may be largely dependent on frequent alcohol consumption.

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“…Among the risk factors for early kidney damage, BP is one of the most important. 20 Indeed, a recent study showed that a higher BP in childhood was correlated with a higher risk of subclinical kidney damage in adults over 30 years of follow‐up. 21 Moreover, short‐term BP variability was independently associated with early kidney abnormalities.…”

Section: Discussionmentioning

confidence: 99%

Association of urinary vanin‐1 with kidney function decline in hypertensive patients

Hosohata

Matsuoka

Kumagai³

2021

J of Clinical Hypertension

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Previously, the authors reported the utility of urinary vanin‐1 as an early biomarker of kidney injury in spontaneously hypertensive rats and in humans. However, little is known about whether urinary vanin‐1 can be used to predict the clinical outcome. This study aimed to evaluate the predictive power of urinary vanin‐1 based on kidney function decline in hypertensive patients. The authors measured urinary vanin‐1 in 147 patients at the baseline and examined its association with the incidence of ≥20% decline in the estimated glomerular filtration rate (eGFR) using the Cox regression analysis. The mean age of the patients averaged 72.9 ± 8.2 years, and 39% were women. Median (interquartile range) urinary vanin‐1 was 0.33 (0–2.6) ng/mg Cr During a median follow‐up of 12 months, 14 patients showed kidney function decline. A higher urinary vanin‐1 level was associated with an increased risk of kidney function decline (hazard ratio, 9.87; 95% CI, 1.11–87.5) (p = .04) in the fully adjusted model. In conclusion, urinary vanin‐1 is an independent risk factor for kidney function decline in hypertensive patients and it could be useful in clinical settings. The underlying pathophysiologic mechanisms warrant additional investigation.

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Hypertension and chronic kidney disease in Asian populations

Abstract: This is an open access article under the terms of the Creative Commons Attribution NonCommercial License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited and is not used for commercial purposes.

Cited by 17 publications

References 31 publications

Metabolomics of Artichoke Bud Extract in Spontaneously Hypertensive Rats

Metabolomics of Artichoke Bud Extract in Spontaneously Hypertensive Rats

Association of Serum High-Density Lipoprotein Cholesterol with High Blood Pressures at Checkup: Results of Kanagawa Investigation of Total Checkup Data from the National Database-9 (KITCHEN-9)

Association of urinary vanin‐1 with kidney function decline in hypertensive patients

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