Hypertension and arterial development. Long-term considerations.

Berry, C. L.

doi:10.1136/hrt.40.7.709

Cited by 56 publications

(21 citation statements)

References 49 publications

(38 reference statements)

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“…There is evidence in animals and human beings that changes of afterload in early life can alter the structure and compliance of the larger arteries. 24 The fetal circulation of the compromised group have changes of regional resistance that may cause redistribution of cardiac output. Cerebral blood flow may be increased, and flow to the trunk may decrease; that is, the so-called ''brain-sparing effect''.…”

Section: Discussionmentioning

confidence: 99%

Placental Circulation, Fetal Growth, and Stiffness of the Abdominal Aorta in Newborn Infants

Mori

Saburi

2006

The Journal of Pediatrics

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Section: Discussionmentioning

confidence: 99%

Placental Circulation, Fetal Growth, and Stiffness of the Abdominal Aorta in Newborn Infants

Mori

Saburi

2006

The Journal of Pediatrics

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“…Intimal thickening at 6 weeks is enough to halve the normal tension imposed on wall elements, assuming that the elastic properties of the neointima match those of the media. Given the putative role of wall tension in stimulating both developmental and pathological medial growth, 33 this decrease in tension may ultimately offset the effects of other growth stimuli that have resulted from the injury.…”

Section: Neointimal Proliferationmentioning

confidence: 99%

Structural changes and recovery of function after arterial injury.

Jamal

Bendeck

Langille

1992

Arterioscler Thromb

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Repair and remodeling processes initiated by arterial injury are thought to be critical in the pathogenesis of important vascular disorders. However, how these processes are related to specific types of injury is not well defined. Consequently, we compared arterial responses to several types of injury. Segments of rabbit carotid arteries were injured by Intraluminal passage of an inflated embolectomy catheter, by hyperdistending the arteries with sterile saline, or by flushing them briefly with Triton X-100. Ballooning and Triton treatment removed the endothelium while imposing hyperdistending or nonhyperdistending injury on the vessel media. Hyperdistension with sterile saline caused medial injury but only transient and focal endothelial denudation. All modes of injury caused medial damage that was repaired within 2-7 days as assessed by vessel wall DNA content and synthesis and by capacity to contract In addition, ballooned arteries recovered their capacity to exhibit diameter reductions induced by decreased blood flow once the endothelium had regenerated. The two injuries that caused endothelial denudation, ballooning and Triton treatment, resulted in equal intimal thickening after 6 weeks despite lower short-and long-term rates of cell replication after Triton-induced Injury. Only ballooning resulted in chronic turnover of intimal smooth muscle cells after injury. No neointimal proliferation followed hyperdistension with saline despite significant medial injury. These latter findings suggest that even severe medial injury does not lead to intimal proliferation in the absence of endothelial denudation.

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“…The foramen sets a limit to the maximum size of the vessel and so should reflect the extent of blood flow through it. The size of the blood vessel, and consequently the foramen, is affected by rheological properties of blood in the vessel -stretch and shear stress (Berry, 1978;Birchard, 1997;Ward et al, 2000). Stretch is related to the radial force exerted on a vessel wall due to the balance between blood pressure and the mechanical properties of the wall.…”

Section: Introductionmentioning

confidence: 99%

Blood flow for bone remodelling correlates with locomotion in living and extinct birds

Allan

Cassey

Snelling

et al. 2014

Journal of Experimental Biology

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Nutrient arteries enter limb bones through discrete foramina on the shafts. They are required for bone remodelling in response to mechanical loading and dynamic forces imposed by locomotion. The cross-sectional area of the nutrient foramen of the femur represents an index of blood flow rate to the shaft and thus provides insight into the animal's level of activity. Morphometric data on femoral length, mass and foramen size from 100 extant bird species and eight extinct moa species were analysed allometrically and phylogenetically. The nutrient foramen blood flow index (Q i ) and femur mass (M f ) increase with body mass (M b ). At 1 kg body mass, cursorial species have approximately 2.1 times higher Q i and 1.9 times heavier M f than volant species. The scaling of Q i on M f is independent of the primary mode of locomotion, but the ratio Q i /M f decreases significantly in larger birds, although absolute Q i increases. The overall avian equation for Q i on M b is not significantly different from previous data from mammals, but when differences in blood pressure are accounted for, estimated blood flow to the femur is approximately 1.9 times higher in cursorial birds than in mammals, possibly in relation to bipedalism and quadrupedalism, respectively. Femoral bone blood flow in both endothermic groups is estimated to be 50-100 times higher than in ectothermic reptiles.

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Hypertension and arterial development. Long-term considerations.

Cited by 56 publications

References 49 publications

Placental Circulation, Fetal Growth, and Stiffness of the Abdominal Aorta in Newborn Infants

Placental Circulation, Fetal Growth, and Stiffness of the Abdominal Aorta in Newborn Infants

Structural changes and recovery of function after arterial injury.

Blood flow for bone remodelling correlates with locomotion in living and extinct birds

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