Hypertension after renal transplantation and polymorphism of genes involved in essential hypertension: ACE, AGT, AT1R and ecNOS

el-EA, Basset; Berthoux, P; Cecillon, S; Deprle, C; Thibaudin, Damien; Filippis, De; E, Alamartin; Berthou, Flavien

doi:10.5414/cnp57192

Cited by 30 publications

(3 citation statements)

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“…Therefore, hypertension is one of the imperative contributing factors associated with both causation and progression of renal failure [ 6 ]. It is a common, polygenic and complex disorder resulting from interaction of several genes with each other and with environmental factors [ 7 ].…”

Section: Introductionmentioning

confidence: 99%

High prevalence of ACE DD genotype among north Indian end stage renal disease patients

et al. 2006

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BackgroundThe Renin-Angiotensin system (RAS) is a key regulator of both blood pressure and kidney functions and their interaction. In such a situation, genetic variability in the genes of different components of RAS is likely to contribute for its heterogeneous association in the renal disease patients. Angiotensin converting enzyme-1 (ACE-1) is an important component of RAS which determines the vasoactive peptide Angiotensin-II.MethodsIn the present study, we have investigated 127 ESRD patients and 150 normal healthy controls from north India to deduce the association between ACE gene polymorphism and ESRD. The inclusion criteria for patients included a constantly elevated serum creatinine level above normal range (ranging from 3.4 to 15.8) and further the patients were recommended for renal transplantation. A total of 150 normal healthy controls were also genotyped for ACE I/D polymorphism. The criterion of defining control sample as normal was totally based on the absence of any kidney disease determined from the serum creatinin level. Genotyping of ACE I/D were assayed by polymerase chain reaction (PCR) based DNA amplification using specific flanking primers Based on the method described elsewhere.ResultsThe difference of DD and II genotypes was found highly significant among the two groups (p = 0.025; OR = 3.524; 95%CI = 1.54-8.07). The combined genotype DD v/s ID+II comparison validated that DD genotype is a high risk genotype for ESRD (p = 0.001; OR = 5.74; 95%CI limit = 3.4-8.5). However, no correlation was obtained for different biochemical parameters of lipid profile and renal function among DD and non DD genotype. Interestingly, ~87% of the DD ESRD patients were found hypertensive in comparison to the 65% patients of non DD genotypeConclusionBased on these observations we conclude that ACE DD genotype implicate a strong possible role in the hypertensive state and in renal damage among north Indians. The study will help in predetermining the timing, type and doses of anti-hypertensive therapy for ESRD patients.

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Section: Introductionmentioning

confidence: 99%

High prevalence of ACE DD genotype among north Indian end stage renal disease patients

et al. 2006

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“…El‐Essawy et al found no differences between transplant recipients and controls with respect to AGT M235T polymorphism (17). The same authors noted no relationships between the AGT M235T variants and the prevalence or severity of post‐transplantation hypertension.…”

Section: Discussionmentioning

confidence: 99%

Angiotensinogen and plasminogen activator inhibitor‐1 gene polymorphism in relation to chronic allograft dysfunction*

Reis¹,

Arınsoy²,

Derici³

et al. 2004

Clinical Transplantation

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: Chronic allograft dysfunction (CAD) is the most common cause of allograft failure in the long‐term, and current immunologic strategies have little effect on this condition. The renin‐angiotensin system (RAS) plays important roles progression of chronic renal disease. It is thought that plasminogen activator inhibitor‐1 (PAI‐1) functions in the RAS, in addition to involvement in thrombotic risk and fibrosis. This study investigated possible links between angiotensinogen (AGT) genotypes (M235T/MM, MT, TT) and PAI‐1 genotypes (4G4G, 4G5G, 5G5G) and CAD assessments of both types of polymorphism were performed in 82 renal allograft recipients. One hundred healthy subjects were also investigated for AGT polymorphism, and 80 healthy subjects for PAI‐1 polymorphism. Genotypes were determined using polymerase chain reaction (PCR) sequence‐specific primers, and PCR followed by restriction fragment length polymorphism analysis. Kidney recipients with CAD had significantly lower frequencies of the MM genotype and the M allele than the recipients without CAD (p < 0.05 and <0.001). The transplant recipients with CAD also had significantly lower frequencies of the 5G5G genotype and the 5G allele than those without CAD (p < 0.001 and <0.05). Determination of AGT M235T and PAI‐1 genotypes prior to transplantation may help identify patients who at risk for chronic renal transplant dysfunction.

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“…The distribution of the ACE gene polymorphisms in the Caucasian population is similar in different European countries; with incidences of II, ID, and DD genotypes in Germany [88] of 26%, 50%, and 27%, respectively; in France [89] of 22%, 51%, and 27%; in Sweden [90] of 23%, 50%, and 27%. In the present study we accumulated data for the Hungarian population (23%, 55%, 22%) that were in accordance with these studies.…”

Section: Gene Polymorphisms Of the Renin-angiotensin System In Juvenimentioning

confidence: 92%

Pathogenetic studies in juvenile essential hypertension and uremia

Papp

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Hypertension after renal transplantation and polymorphism of genes involved in essential hypertension: ACE, AGT, AT1R and ecNOS

Cited by 30 publications

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High prevalence of ACE DD genotype among north Indian end stage renal disease patients

High prevalence of ACE DD genotype among north Indian end stage renal disease patients

Angiotensinogen and plasminogen activator inhibitor‐1 gene polymorphism in relation to chronic allograft dysfunction*

Pathogenetic studies in juvenile essential hypertension and uremia

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