Hyperspectral imaging system in the delineation of Ill‐defined basal cell carcinomas: a pilot study

Abstract

HIS has the potential to be an easy and fast aid in the preoperative delineation of ill-defined BCCs, but further adjustment and larger studies are warranted for an optimal outcome.

Key characteristics of basal cell carcinoma with large subclinical extension

“…We found that BCCs within the basosquamous, metatypical, micronodular, infiltrative, morpheaform and sclerosing subtypes were more likely to have LSE (Table ). Our findings are consistent with past literature, which presents these subtypes as more histologically aggressive . As such, it is important for clinicians to remember these subtypes as being more aggressive, since they exhibit more LSE within their particular BCC subtype.…”

“…Both univariate and multivariate analyses suggest BCCs presenting in Zones 1 and 2 are more likely to have LSE than BCCs in Zone 3. BCCs are typically located on the most sun‐exposed areas of the body, particularly the head and neck . Several retrospective studies found the central face to be a high‐risk location for the development of BCC – the nose, cheek, forehead, scalp, periauricular and periorbital areas were the most prominent and sun‐damaged areas .…”

“…BCCs are typically located on the most sun-exposed areas of the body, particularly the head and neck. 16,[24][25][26][27] Several retrospective studies found the central face to be a high-risk location for the development of BCCthe nose, cheek, forehead, scalp, periauricular and periorbital areas were the most prominent and sun-damaged areas. 14,16,24,25,28,29 The ear is another common area for BCC presentation.…”

“…Our findings are consistent with past literature, which presents these subtypes as more histologically aggressive. 7,14,24,27,31 As such, it is important for clinicians to remember these subtypes as being more aggressive, since they exhibit more LSE within their particular BCC subtype. In addition, in our cohort, when adjusting for age, sex, Fitzpatrick skin type, prior history of BCC and location of BCC, superficial and superficial multicentric subtypes were found to have twice the odds of LSE (Table 2).…”

On the spectral signature of melanoma: a non-parametric classification framework for cancer detection in hyperspectral imaging of melanocytic lesions

“…Macroscopic HSI has been thoroughly employed in tissue classification [8][9][10][11][12][13], lesion segmentation [14,15], and quantification of detectable chromophores [16,17], among others (for further discussion on the capabilities of HSI as a clinical technique, please refer to reviews [17], [18], [19] and [20]). In the field of dermatology, multispectral digital skin lesion analysis (MSDSLA) devices are capable of detecting inflammation [21], segmenting and differentiating between malignant and benign melanocytic and non-melanocytic lesions [22][23][24][25][26][27][28][29]. Chromophores present in melanocytic lesions have been evaluated in large spectroscopic studies as well [30].…”