Hyperserotonemia in Adults with Autistic Disorder

Hranilović, Dubravka; Bujas-Petković, Zorana; Vragović, Renata; Vuk, Tomislav; Hock, Karlo; Jernej, Branimir

doi:10.1007/s10803-006-0324-6

Cited by 108 publications

(71 citation statements)

References 28 publications

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“…An early study in 1961 showed an increased levels of endogenous 5-HT in whole blood in 26% of autistic children [19]. These results have also been confirmed by other studies [20].…”

Section: Discussionsupporting

confidence: 62%

Autism and Fragile X: Is There a Neurochemical Link?

Meguid

Atta

Rashed

et al. 2014

Open Access Maced J Med Sci

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“…An early study in 1961 showed an increased levels of endogenous 5-HT in whole blood in 26% of autistic children [19]. These results have also been confirmed by other studies [20].…”

Section: Discussionsupporting

confidence: 62%

Autism and Fragile X: Is There a Neurochemical Link?

Meguid

Atta

Rashed

et al. 2014

Open Access Maced J Med Sci

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“…Evidence suggests that there is a large amount of genetic, phenotypic, and clinical heterogeneity among individuals with ASD. For example, preliminary evidence suggests that about 30% of people with ASD might have hyperserotonaemia 133 and thus are likely to respond well to drugs that modulate the serotonergic system, whereas about 70% do not, which could also explain the low treatment response to serotonergic drugs in large-scale clinical trials. Thus, ASD probably cannot be treated with a one-size-fi ts-all approach; treatment needs to be more personalised and individually tailored.…”

Section: Diagnostic Methods For Asd and Their Limitationsmentioning

confidence: 99%

Neuroimaging in autism spectrum disorder: brain structure and function across the lifespan

Ecker

Bookheimer

Murphy

2015

The Lancet Neurology

377

294

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Over the past decade, in-vivo MRI studies have provided many invaluable insights into the neural substrates underlying autism spectrum disorder (ASD), which is now known to be associated with neurodevelopmental variations in brain anatomy, functioning, and connectivity. These systems-level features of ASD pathology seem to develop diff erentially across the human lifespan so that the cortical abnormalities that occur in children with ASD diff er from those noted at other stages of life. Thus, investigation of the brain in ASD poses particular methodological challenges, which must be addressed to enable the comparison of results across studies. Novel analytical approaches are also being developed to facilitate the translation of fi ndings from the research to the clinical setting. In the future, the insights provided by human neuroimaging studies could contribute to biomarker development for ASD and other neurodevelopmental disorders, and to new approaches to diagnosis and treatment.

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“…The first one was the immediate 5HT precursor, which elevated 5HT levels without acting that genes which regulate 5HT metabolism should be considered as potential candidates in 5HT-related behavioral disorders. Indeed, our findings in autistic subjects indicated that disrupted 5HT homeostasis is related to alterations in 5HT metabolism rather than 5HT uptake [45,46]. Second, the developmental disbalance induced in both 5HT-compartments …”

Section: The Effects Of Pharmacological Treatments On the Expression mentioning

confidence: 64%

Expression of 5HT-related genes after perinatal treatment with 5HT agonists

Blažević

Hranilović

2013

Translational Neuroscience

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Serotonin (5HT) is a biologically active amine with diverse roles in the mammalian organism. Developmental alterations in 5HT homeostasis could lead to exposure of the developing brain to non-optimal serotonin concentrations that may result in developmental and behavioral deficits. In order to explore the molecular basis of the effects of developmental disturbances on 5HT metabolism on adult central 5HT homeostasis, observed in our previous studies, we measured changes in gene expression of the neuronal 5HT-regulating proteins in adult animals after perinatal treatment with the immediate 5HT precursor 5-hydroxytryptophan (5HTP, 25 mg/kg), or monoamine oxidase (MAO) inhibitor tranylcypromine (TCP 2 mg/kg), during the period of the most intensive development of 5HT neurons -from gestational day 12 until postnatal day 21. Adult animals were sacrificed and the relative mRNA levels for tryptophan hydroxylase 2, MAO A, MAO B, receptors 5HT 1A and 5HT 2A , 5HT transporter (5HTT) and vesicular monoamine transporter (VMAT) were determined in the raphe nuclei region and prefrontal cortex using Real-Time Relative qRT-PCR. In comparison to the saline treated animals, treatment with 5HTP caused mild but significant increase in MAO A and MAO B mRNA abundance. TCP-treated animals, besides an increase in mRNA abundance for both MAO genes, displayed significantly increased 5HTT and VMAT2 mRNA levels and significantly decreased 5HT 1A receptor mRNA levels. Our results suggest that perinatal exposure of rats to 5HTP, and especially TCP, induces long-lasting/permanent changes in the expression of 5HT-regulating genes, that presumably underlie 5HT-related neurochemical and behavioral changes in adult animals.

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Hyperserotonemia in Adults with Autistic Disorder

Cited by 108 publications

References 28 publications

Autism and Fragile X: Is There a Neurochemical Link?

Autism and Fragile X: Is There a Neurochemical Link?

Neuroimaging in autism spectrum disorder: brain structure and function across the lifespan

Expression of 5HT-related genes after perinatal treatment with 5HT agonists

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