Hypersensitivity to Vespa velutina nigrithorax: an emerging problem in Portugal?

Caldeira, L.; Silva, M I T; Pedro, Elisa; Cosme, Joana

doi:10.23822/eurannaci.1764-1489.279

Cited by 4 publications

(4 citation statements)

References 6 publications

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“…When considering the frequency of sensitization to Vespa velutina, the number of reported cases of SR due to this Hymenoptera is increasing worldwide, with Portugal mirroring this trend (3,4,26,27).…”

Section: F O R P U B L I C a T I O Nmentioning

confidence: 99%

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Managing systemic reactions and venom immunotherapy in vespid-venom allergy: observations from a retrospective study of Portuguese patients

Ferreira,

Gomes,

Vieira

et al. 2024

Eur Ann Allergy Clin Immunol

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Section: F O R P U B L I C a T I O Nmentioning

confidence: 99%

“…Recently, sensitization profiles of Portuguese patients with VVN reactions have been published helping to further understand VVN hypersensitivity (26,27).…”

Section: F O R P U B L I C a T I O Nmentioning

confidence: 99%

Managing systemic reactions and venom immunotherapy in vespid-venom allergy: observations from a retrospective study of Portuguese patients

Ferreira,

Gomes,

Vieira

et al. 2024

Eur Ann Allergy Clin Immunol

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“…According to studies conducted so far on patients with anaphylaxis due to VVN, fewer than 25% recalled previous stings from the same insect, although they reported previous stings to other Hymenoptera (especially common wasps) (4). Furthermore, different studies results show that patients who experienced anaphylaxis to Hymenoptera venom with and without previous VVN stings have similar sensitization patterns, suggesting that sensitization in patients allergic to VVN may come through a different species (10). Specifically, most patients with anaphylaxis due to VVN show a very high predominance of Vespula spp.…”

mentioning

confidence: 99%

“…venoms suggest that a specific venom for VVN could be relevant for a diagnostic and therapeutic use (14). In particular, a specific VVN immunotherapy in patients with anaphylactic reactions after Hymenoptera sting, documented IgE sensitization to VVN and a high risk of being re-stung in view of their professional and leisure activities should be carefully considered (10).…”

mentioning

confidence: 99%

The increasing cases of allergy to Vespa velutina in Europe: which immunotherapy?

Bilò¹,

Turillazzi²,

Cortellini³

et al. 2023

Eur Ann Allergy Clin Immunol

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Vespa velutina nigrithorax (VVN), accidentally introduced in France in 2004 from South-East Asia and rapidly spread across Europe (1), may cause relevant health problems to humans due to its venom: indeed, the proteins contained in VVN's venom are able to act both as toxins and allergens, and deaths due to organ dysfunction induced by toxins in venom and to fatal allergic reactions were both reported (2-5). The two most dangerous groups of toxins identified are the hemostasis-impairing toxins, that participate in the blood coagulation cascade with a distinct hemolytic effect, probably representing the main lethal factor of the multiple organ failure produced by VVN stings, and neurotoxins, that can induce varying degrees of nerve degeneration and paralysis (2). About the allergenic components, according to the serum samples from patients who had experienced allergenic reactions, two most common allergens have been identified: Vesp v 5, corresponding to antigen 5, and Vesp v 1, corresponded to A1-phospholipase (one of whose most interesting features is its glycosylated nature) (4, 6, 7). Despite this, only Vesp v 5 may be considered a dominant allergen, with more than 85% of patients having IgE against it, while Vesp v 1 has been detected in less than 50% of patients (6-8) Additionally, IgE against Vesp v 5 also resulted higher than IgE against VVN whole venom (9, 10). Other two components purified in the venom of VVN specimen, Vesp v 2A and 2B (two hyaluronidase isoforms) have been characterized as potential allergens, but specific IgE against these isoforms has not yet been demonstrated (4,11,12).Since there is no specific available VIT for VVN yet, several studies focused on the importance of finding out if VVN stung patients with severe systemic reactions may be treated with actual Hymenoptera commercially available extracts. By studying the degree of similarity with respect to antigen 5 and A1-phospholipase from Vespula spp., Vespa crabro and Polistes dominula, it was found that both VVN antigen 5 and A1phospholipase show a very high homology with Vespa crabro and Vespula spp. Instead, a lower percentage of structural identity has been found with antigen 5 and A1-phospholipase present in Polistes dominula (12).

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The risk of anaphylaxis on holidays

Ridolo,

Barone,

Ottoni

et al. 2024

Current Opinion in Allergy &Amp; Clinical Immunology

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Purpose of review The goal of this review is to summarize the potential causes of anaphylaxis in the different holiday contexts, providing practical suggestions aimed to mitigate the stress challenged by allergic patients because of unfamiliar situations. Recent findings A regard was reserved to potential food triggers, particularly uncommon ones and typical of certain destinations, and to arthropods responsible for anaphylaxis. Summary This review highlights the potential risk of anaphylaxis due to the unusual contexts more experienced during holidays (i.e., travels, outdoor activities and eating out). Moreover, it underlines the need for a further allergological education in these cases, in order to prepare allergic patients to avoid and manage undesired situations.

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Hypersensitivity to Vespa velutina nigrithorax: an emerging problem in Portugal?

Cited by 4 publications

References 6 publications

Managing systemic reactions and venom immunotherapy in vespid-venom allergy: observations from a retrospective study of Portuguese patients

Managing systemic reactions and venom immunotherapy in vespid-venom allergy: observations from a retrospective study of Portuguese patients

The increasing cases of allergy to Vespa velutina in Europe: which immunotherapy?

The risk of anaphylaxis on holidays

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