Hypersensitivity to Milk and Sudden Death in Infancy

Parish, W. E.; Barrett, A. M.; Coombs, R.R.A.; Gunther, Mavis; Camps, Francis E.

doi:10.1016/s0140-6736(60)92187-5

Cited by 134 publications

(27 citation statements)

References 4 publications

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“…A high incidence and a high concentration of such antibodies have been reported in children with chronic respiratory disease, in cot deaths, ulcerative colitis in the acute phase, systemic lupus erythematosus and a-y-A-globulinaemia [3,4,7,15,18]. These antibodies are not believed to be the primary cause of the disease but more probably a secondary phenomenon.…”

Section: Discussionmentioning

confidence: 99%

Human Antibodies to Bovine γ-Globulin

Foucard¹,

Bennich²,

Johansson³

et al. 1975

Int Arch Allergy Immunol

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Antibodies to bovine γ-globulin (anti-BGG antibodies) were detectable by a radio-immunoassay in 70% of healthy blood donors but, generally, the titres were low. Significantly increased concentrations of anti-BGG antibodies were found in patients lacking IgA but not in patients with allergic disorders. The anti-BGG antibodies were shown to give rise to falsely high IgE values in the radio-immunosorbent test for IgE determination (RIST) when a sheep anti-IgE antiserum was used. Furthermore, falsely positive results can sometimes be caused by such antibodies in the determination of cow-dander- or cow’s-milk-specific IgE by the radio-allergosorbent test (RAST). When a rabbit anti-IgE antiserum was used instead of the sheep anti-IgE, normal IgE levels and negative RAST results were obtained. The difference is explained by the higher degree of cross-reactivity between the anti-BGG antibodies and sheep γ-globulin than between anti-BGG antibodies and rabbit γ-globulin.

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Section: Discussionmentioning

confidence: 99%

Human Antibodies to Bovine γ-Globulin

Foucard¹,

Bennich²,

Johansson³

et al. 1975

Int Arch Allergy Immunol

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“…Indeed it has been noted 'that sudden unexpected deaths at home are a "mixed bag" ',1 and the possible causes include respiratory infections,2 and hypersensitivity to cows' milk protein. 3 Considerable effort has been made to define procedures for predicting infants at increased risk of sudden unexpected death (referred to as high risk infants in this paper). Carpenter and Emery" developed a scoring technique based on parameters available at birth (mother's age, blood group, and incidence of urinary tract infection; duration of second stage labour; birthweight; twin; determination to breast feed).…”

mentioning

confidence: 99%

Respiratory patterns and risk of sudden unexpected death in infancy.

Franks¹,

Watson²,

Brown³

et al. 1980

Archives of Disease in Childhood

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SUMMARY The overnight respiratory patterns of 25 infants at high risk and 42 infants at low risk of sudden unexpected death were studied during the first 6 months of life. 'Risk' was determined using the birth scoring criteria of Carpenter and Emery. Recordings were made at home using a twinchannel radar chest movement detector which was designed to avoid the need for contact with the infant. The recordings were analysed for respiratory frequency, total duration of apnoea, periodic breathing, duration of regular breathing, and amount of body movement. The high risk group of infants showed respiratory frequencies that were significantly higher than those of the low risk group. None of the other parameters showed significant differences between the groups. These findings do not support the widespread use of home apnoea monitors for infants.

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“…It is now known that small amounts of certain ingested proteins can enter the circulation in an apparently unaltered anti genic state [1][2][3][4][5][6][7][8][9][10]. Antibodies against milk proteins are present in the sera of a substantial number of children [11,12] and the possibility of a relationship between this phenomenon and chronic respiratory [13-15J and gastrointestinal [14, 16] diseases as well as cot death [17] has been discussed.Although the absorption of different antigens has been proven, investigation into the factors which might determine whether or not a given antigen might enter the circulation has been neglected. To study this problem, a method employing a modification of the passive cutaneous anaphylaxis (PCA) technique [18] to detect the presence of antigen in the circulation after its administration directly into the stomach of guinea pigs was used.…”

mentioning

confidence: 99%