Hypersensitivity to ketoconazole

Verschueren, G. L. A.; Bruynzeel, D. P.

doi:10.1111/j.1600-0536.1992.tb00868.x

Cited by 7 publications

(1 citation statement)

References 9 publications

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“…A number of case reports have mentioned hypersensitivity reactions in patients receiving ketoconazole in either oral or dermal form [ 1 – 4 ]. Liu et al described a 72-year-old woman who developed anaphylaxis and severe hypotension unresponsive to 2 L of 0.9% NaCl intravenous (IV) fluid resuscitation after taking ketoconazole [ 2 ].…”

Section: Introductionmentioning

confidence: 99%

Severe Adverse Reactions Following Ketoconazole, Fluconazole, and Environmental Exposures: A Case Report

Lieberman

Curtis

2018

Drug Saf - Case Rep

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In this case report, we describe a 66-year-old man who developed multiple adverse reactions beginning at age 56 after exposure to several azole antifungal drugs including ketoconazole and fluconazole. He also had a history of more than 40 years exposure to chemicals including pesticides, wood preservatives, fertilizers, and welding chemicals. His reactions involved dehydration (requiring several liters of intravenous fluids in less than an hour to alleviate this condition), angioedema, nausea, tinnitus, hypotension, and difficulty breathing. His acute adverse reactions were triggered by a wide range of chemicals including gasoline, diesel fuel, pesticides, chlorine, topical isopropyl alcohol, and paper mill emissions. His acute reactions were also triggered by a wide range of foods such as bananas, apples, milk, white potatoes, and processed sweets. A number of mechanisms could be responsible for his increased sensitivity to chemicals following exposure to fluconazole/ketoconazole, including inhibition of P450 and other detoxification enzymes, acetaldehyde buildup, and neurogenic sensitization.

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Section: Introductionmentioning

confidence: 99%

Severe Adverse Reactions Following Ketoconazole, Fluconazole, and Environmental Exposures: A Case Report

Lieberman

Curtis

2018

Drug Saf - Case Rep

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Contact dermatitis from ketoconazole cream

et al. 1992

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titis had occurred 10 years previously after using Macmiror Complex® pessaries.Patch tests with European standard series showed a reaction to PTBPF resin at 2 and 3 days ( + I + + ).Patch tests with components of Macmiror® and Macmiror Complex® pessaries showed a reaction to nifuratel I% acet. at 2 and 3 days (+I++), with no reactions to nystatin 1% acet. and 1% aq., propyl and ethyl parabens 3% pet., or propylene glycol 2% pet. DiscussionTo our knowledge, only 5 cases of allergic contact dermatitis from nifuratel have been reported: 3 from Macmiror® and 2 from EmorriJ®. Although nifuratel is widely prescribed to women, paradoxically, all previous reports concerned males using topical nifuratel as an antihaemorrhoidal or having sexual intercourse with partners using topical nifuratel.Britz & Maibach (5) showed that vulvar skin was more susceptible to irritants than the forearm. Women with chronic vulvovaginitis run the risk of developing medicament dermatitis (6). In our case, vulvar contact dermatitis was observed with no vaginal involvement. Fisher (7) underlines that vulvar -SHORT COMMUNICATIONS skin is more easily irritated than the vaginal mucosa; might vulvar -skin also be more easily sensitized?

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