Hypersensitivity to cold stimulation associated with regional osteoporotic changes in tail-suspended mice

Ibe, Koji; Iba, Kousuke; Hanaka, Megumi; Kiyomoto, Kenta; Hayakawa, Hikaru; Teramoto, Atsushi; Emori, Makoto; Yamashita, Toshihiko

doi:10.1007/s00774-020-01086-1

Cited by 3 publications

(2 citation statements)

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“…On the other hand, we previously reported several studies focused on the relationship between transient receptor potential vanilloid 1 (TRPV1) and bone pain. [8][9][10][11][12] In those studies, we demonstrated that TRPV1 has important roles as a nociceptive sensor for increased pain-related molecules under pathophysiological conditions in bone tissue. We, therefore, focused on TRPV1 expression in the current CRPS mouse model in response to fracture and immobilization of limb in this study.…”

Section: Introductionmentioning

confidence: 87%

“…In particular, this method of physical therapy could afford a suitable tool for treating patients who avoid movement and functional use due to hypersensitivity. On the other hand, we previously reported several studies focused on the relationship between transient receptor potential vanilloid 1 (TRPV1) and bone pain 8–12 . In those studies, we demonstrated that TRPV1 has important roles as a nociceptive sensor for increased pain‐related molecules under pathophysiological conditions in bone tissue.…”

Section: Introductionmentioning

confidence: 96%

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Remission of hypersensitivity by simple weight load stimuli in a complex regional pain syndrome mouse model

Kiyomoto,

Emori,

Hanaka

et al. 2023

Journal Orthopaedic Research

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Painful sensitivity of the hand or foot are the most common and debilitating symptoms of complex regional pain syndrome (CRPS). Physical therapy is standard treatment for CRPS, but evidence supporting its efficacy is minimal and it can be essentially impossible for CRPS patients to actively exercise the painful limb. Using the well‐characterized distal tibial fracture CRPS mouse model, we compared the therapeutic effects of several weeks of daily hindlimb loading versus rotarod walking exercise. The effects of loading and exercise were evaluated by weekly testing of hind‐paw withdrawal thresholds to von Frey fibers and radiant heat, as well as measurements of paw and ankle edema. At 6 weeks after fracture, the mice were killed and the ipsilateral femur, spinal cord and L4/5 dorsal root ganglia, and hind‐paw skin collected for PCR assays and paw skin Immunohistochemistry evaluation. Hindlimb loading reduced hind‐paw von Frey allodynia and heat hyperalgesia and edema within a week and these effects persisted for at least a week after discontinuing treatment. These therapeutic effects of loading exceeded the beneficial effects observed with rotarod walking exercise in fracture mice. Levels of nerve growth factor and transient receptor potential vanilloid 1 (TRPV1) immunostaining in the hind‐paw skin were increased at 6 weeks after fracture, and both loading and exercise treatment reduced increases. Collectively, these results suggest that loading may be an effective and possibly curative treatment in CRPS patients with sensitivity in the affected limb.

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Section: Introductionmentioning

confidence: 87%

Section: Introductionmentioning

confidence: 96%

Remission of hypersensitivity by simple weight load stimuli in a complex regional pain syndrome mouse model

Kiyomoto,

Emori,

Hanaka

et al. 2023

Journal Orthopaedic Research

Self Cite

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Static stretching of the ankle prevents cold hypersensitivity associated with limb immobilization in model mice

Ibe,

Iba,

Emori

et al. 2023

Journal of Orthopaedic Science

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Osteosarcopenia and Pain: Do We Have a Way Out?

et al. 2023

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Osteosarcopenia (OSP) is a geriatric syndrome characterized by the coexistence of osteoporosis and sarcopenia and associated with an increased risk of fragility fractures, disability, and mortality. For patients with this syndrome, musculoskeletal pain represents the most significant challenge since, in addition to limiting the individual’s functionality and promoting disability, it has a huge psychological burden involving anxiety, depression, and social withdrawal. Unfortunately, the molecular mechanisms involved in the development and persistence of pain in OSP have not yet been fully elucidated, although immune cells are known to play a key role in these processes. Indeed, they release several molecules that promote persistent inflammation and nociceptive stimulation, resulting in the gating of ion channels responsible for the generation and propagation of the noxious stimulus. The adoption of countermeasures to counteract the OSP progression and reduce the algic component appears to be necessary, providing patients with a better quality of life and greater adherence to treatment. In addition, the development of multimodal therapies, based on an interdisciplinary approach, appears to be crucial, combining the use of anti-osteoporotic drugs with an educational programme, regular physical activity, and proper nutrition to eliminate risk factors. Based on this evidence, we conducted a narrative review using the PubMed and Google Scholar search engines to summarize the current knowledge on the molecular mechanisms involved in the pain development in OSP and the potential countermeasures to be taken. The lack of studies addressing this topic highlights the need to conduct new research into the resolution of an ever-expanding social problem.

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Hypersensitivity to cold stimulation associated with regional osteoporotic changes in tail-suspended mice

Cited by 3 publications

References 39 publications

Remission of hypersensitivity by simple weight load stimuli in a complex regional pain syndrome mouse model

Remission of hypersensitivity by simple weight load stimuli in a complex regional pain syndrome mouse model

Static stretching of the ankle prevents cold hypersensitivity associated with limb immobilization in model mice

Osteosarcopenia and Pain: Do We Have a Way Out?

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