Hypersensitivity reactions to racemic calcium folinate (leucovorin) during FOLFOX and FOLFIRI chemotherapy administrations

Ureña-Tavera, Alicia; Zamora-Verduga, Miriam; Madrigal-Burgaleta, Ricardo; Ángel-Pereira, Denisse; Berges-Gimeno, M P; Álvarez-Cuesta, Emilio

doi:10.1016/j.jaci.2014.09.045

Cited by 20 publications

(41 citation statements)

References 6 publications

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“…Signs and symptoms from initial reactions and characteristics of patients were collected as in previous articles by our group . Additionally, oxaliplatin‐specific IgE was determined by ImmunoCAP ® (Thermo Fisher Scientific Waltham, MA USA) in all oxaliplatin‐reactive patients.…”

Section: Methodsmentioning

confidence: 99%

“…As in previous works by our group , patients were classified into two groups (high‐risk or medium‐/low‐risk) according to their risk assessment.…”

Section: Methodsmentioning

confidence: 99%

“…Trained personnel in adequate settings performed and assessed ST on all referred patients according to previous articles . ST concentrations used by our group are shown in Table .…”

Section: Methodsmentioning

confidence: 99%

“… As in previous studies , drugs were prepared by the Pharmacy Department Cytotoxic Unit. For skin prick test, a drop of the drug at the maximal concentration was applied to the volar surface of the forearm by the use of a skin prick test lancet.…”

Section: Methodsmentioning

confidence: 99%

“…Drug desensitization is a therapeutic technique which induces a temporary state of tolerance to a drug responsible for a proven HSR . An international consensus as well as previous articles by our group recommends diagnostic DPT (whenever feasible) prior to drug desensitization.…”

mentioning

confidence: 99%

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Delving into cornerstones of hypersensitivity to antineoplastic and biological agents: value of diagnostic tools prior to desensitization

Álvarez-Cuesta

Madrigal-Burgaleta

Ángel-Pereira

et al. 2015

Allergy

144

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These are the first reported data based on more than 100 DPTs with antineoplastic and biological agents (paclitaxel, oxaliplatin, rituximab, infliximab, irinotecan, and other drugs). Implementation of DPT in diagnostic protocols helps exclude hypersensitivity (in 36% of all referred patients), and avoids unnecessary desensitizations in nonhypersensitive patients (30-56% of patients, depending on culprit-drug). Drug provocation test is vital to validate diagnostic tools; consequently, quality data are shown on oxaliplatin-specific IgE and oxaliplatin-ST in the largest series of oxaliplatin-reactive patients reported to date (74 oxaliplatin-reactive patients). Identifying phenotypes and predictors of a diagnosis of hypersensitivity may be helpful for tailored plans.

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Section: Methodsmentioning

confidence: 99%

“…As in previous works by our group , patients were classified into two groups (high‐risk or medium‐/low‐risk) according to their risk assessment.…”

Section: Methodsmentioning

confidence: 99%

“…Trained personnel in adequate settings performed and assessed ST on all referred patients according to previous articles . ST concentrations used by our group are shown in Table .…”

Section: Methodsmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

mentioning

confidence: 99%

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