Hypersensitivity Reactions to Marijuana

Characterization of Cannabis Sativa Allergens

“…3,5 In this study, the prominent IgE reactive bands were identified as RuBisCO and oxygen-evolving enhancer protein 2. Multiple peptides for the large (55 kDa) and small chains (14 kDa) of RuBisCO were identified in the LCMS analysis.…”

“…1 As a result of the increasing social and medical usage, reports of allergic sensitization to marijuana are increasing in the peer reviewed literature. [2][3][4][5][6][7][8][9][10] Cases have been reported where hypersensitivity and even anaphylactic responses have been associated with marijuana use and clinical symptoms include sore throat, nasal congestion, rhinitis, pharyngitis, wheezing, dyspnea, angioedema and lacrimation. 2-4, 11, 12 In chronic and high dose users more severe manifestations of bronchitis and asthma with reduced vital capacity have been reported.…”

Evaluation of a medicinal cannabis manufacturing facility with an indoor and outdoor grow operation.

“…Other studies have also demonstrated dermal reactions such as an urticarial rash (hives) in subjects who directly contact cannabis [Basharat et al 2011;Ozyurt et al 2014]. Urticaria has also occurred in forensic specialists and law enforcement officers following the handling of cannabis [Herzinger et al 2011;Majmudar et al 2006;Mayoral et al 2008;Williams et al 2008].…”

Occupational health and safety in cannabis production: an Australian perspective

“…In the 1700s, Bernardino Ramazzini observed in his Treatise on Diseases of Workers that hemp and flax workers were exposed to acrid and harmful dusts that caused ceaseless coughing, followed by asthma [38]. Known health effects of cannabis are predominantly based on the deliberate exposure by inhalation, ingestion, contact, or injection [39][40][41][42][43][44][45], but little is known of the potential health impacts from long-term occupational exposure, especially to THC in medicinal cannabis. Health impacts could relate to the unique chemical profile of cannabis, plant pollens and allergens, organic and inorganic dusts, bioaerosols, and volatile organic compounds.…”