Hypersensitivity reactions following measles-mumps-rubella vaccine and dextran-specific IgG response

Novadzki, Iolanda Maria; Zanoni, Giovanna; Chiesa, E.; Puccetti, Antonio; Simone, Rita

doi:10.1016/j.aller.2010.02.006

Cited by 4 publications

(1 citation statement)

References 5 publications

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“…The linkage of vaccine databases with data from the national pharmacovigilance network has been the basis of several studies, some of which concern the safety of the hexavalent vaccine [145,146] and of various pneumococcal vaccines. One study using the database of the Italian Pharmacovigilance Network (Rete Nazionale di Farmacovigilanza) and drug utilisation data for the three vaccines against measles, rubella and mumps (MMR) showed a higher rate of hypersensitivity to Morupar than to the other vaccines [147][148][149]. As a result, Morupar was withdrawn and other alternative vaccines were used instead.…”

Section: Vaccinesmentioning

confidence: 99%

The Role of European Healthcare Databases for Post-Marketing Drug Effectiveness, Safety and Value Evaluation: Where Does Italy Stand?

et al. 2018

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Enormous progress has been made globally in the use of evidence derived from patients' clinical information as they access their routine medical care. The value of real-world data lies in their complementary nature compared with data from randomised controlled trials: less detailed information on drug efficacy but longer observational periods and larger, more heterogeneous study populations reflecting clinical practice because individuals are included who would not usually be recruited in trials. Real-world data can be collected in various types of electronic sources, such as electronic health records, claims databases and drug or disease registries. These data sources vary in nature from country to country, according to national healthcare system structures and national policies. In Italy, a growing number of healthcare databases have been used to evaluate post-marketing drug utilisation and safety in the last two decades. The aim of this narrative review is to describe the available Italian sources of real-world data and their contribution to generating post-marketing evidence on drug use and safety. We also discuss the strengths and limitations of the most commonly used Italian healthcare databases in addressing various research questions concerning drug utilisation, comparative effectiveness and safety studies, as well as health technology assessment and other areas. Key PointsEnormous progress has been made in Italy and globally in the use of evidence derived from patients' clinical data as they access their routine medical care.Several data sources in Italy have been used to assess the effectiveness, safety and economic value of medications, including claims databases, electronic health records and patient registries.

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