Hypersensitivity reaction during epirubicin infusion in a cat

Abstract

LETTERWhile the risk, is deemed low, cats should be monitored closely for infusion-related reactions when epirubicin is administered as hypersensitivity reactions can be serious and require urgent intervention. It may also be prudent to consider a slower rate of drug infusion. If a reaction occurs then drug administration should be discontinued and treatment with H1-antagonists, corticosteroids and/or adrenaline given, depending on severity. Infusion could be continued if the reaction was mild and the clinical signs controlled but this will be case-dependent. The current case suggests that further doses of epirubicin may be administered after hypersensitivity has been observed following H1 blockade. Further studies would however be required to corroborate this. Given the seemingly low incidence of hypersensitivity during epirubicin infusions in cats, it is not believed that routine premedication is necessary at this time.

Comparison of two transarterial chemoembolization regimens in patients with unresectable hepatocellular carcinoma: raltitrexed plus oxaliplatin versus 5-fluorouracil plus oxaliplatin

“…Moreover, there were no allergic reactions or cardiotoxicity during transarterial infusion with raltitrexed, and no studies to date have reported any adverse events in this context. In contrast, allergic reactions and cardiotoxicity frequently occur when antitumor drugs such as oxaliplatin and epirubicin are used [ 10 , 21 - 23 ]. These results indicate that the combination of raltitrexed and oxaliplatin in TACE in patients with unresectable HCC is safe and tolerable.…”

Hypersensitivity reaction associated with subcutaneous glargine insulin therapy in a cat

“…2,3 Previous reports of suspected HRs to pharmaceuticals in veterinary medicine include dexamethasone, 4 ophthalmic medication 5 and human albumin 6 among others. 7,8 …”

“…2,3 Previous reports of suspected HRs to pharmaceuticals in veterinary medicine include dexamethasone, 4 ophthalmic medication 5 and human albumin 6 among others. 7,8 HRs to insulin have been rarely reported in human medicine. [9][10][11]12 To our knowledge, an HR to insulin has not been previously reported in the veterinary literature.…”