Hypersensitivity pneumonitis secondary to residential exposure to Aureobasidium pullulans in 2 siblings

Temprano, James; Becker, Bradley A.; Hutcheson, Patricia S.; Knutsen, Alan P.; Dixit, Anupma; Slavin, Raymond G.

doi:10.1016/s1081-1206(10)60387-0

Cited by 23 publications

(8 citation statements)

References 20 publications

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“…Up to 25% of the cases reported previously in the pediatric literature [5] and few additional case reports [2,3,22] were “familial” cases. Reasons may include (1) publication bias from preferring familial cases; (2) insensitivity of history to detect alone standing early disease, or (3) a higher likelihood for serologic testing in families with affected other members.…”

Section: Discussionmentioning

confidence: 99%

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Hypersensitivity pneumonitis: lessons for diagnosis and treatment of a rare entity in children

Griese

Haug

Hartl

et al. 2013

Orphanet J Rare Dis

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Hypersensitivity pneumonitis (HP) also called exogenous allergic alveolitis = extrinsic allergic alveolitis in children is an uncommon condition and may not be recognized and treated appropriately.To assess current means of diagnosis and therapy and compare this to recommendations, we used the Surveillance Unit for Rare Paediatric Disorders (ESPED) to identify incident cases of HP in Germany during 2005/6. In addition, cases of HP reported for reference from all over Germany to our center in the consecutive year were included.Twenty-three children with confirmed pediatric HP were identified. All (age 9.4 y (4.4-15.1) presented with dyspnoea at rest or with exercise, mean FVC was 39% of predicted, seven of the 23 children already had a chronic disease state at presentation. IgG against bird was elevated in 20, and against fungi in 15. Bronchoalveolar lavage was done in 18 subjects (41% lymphocytes, CD4/CD8 1.99), and lung biopsy in 6. Except 2, all children were treated with prolonged courses of systemic steroids. Outcome was not favourable in all cases.Late diagnosis in up to a quarter of the children with HP and inappropriate steroid treatment must be overcome to improve management of HP. Inclusion of children with HP into international, web-based registry studies will help to study and follow up such rare lung diseases.

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Section: Discussionmentioning

confidence: 99%

“…In children it is a relatively uncommon condition and the two major inciting allergens are bird (avian) allergens including down and inhaled particles derived from fungi, like thermophilic actinomycetes, or rarely fusarium [1], aureobasidium [2,3] and epicoccum [4]. …”

Section: Introductionmentioning

confidence: 99%

Hypersensitivity pneumonitis: lessons for diagnosis and treatment of a rare entity in children

Griese

Haug

Hartl

et al. 2013

Orphanet J Rare Dis

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“…Pupils or the staff may also have been a source of them as these fungi have been isolated from people (Salkin et al 1986;Bolignano, Criseo 2003;Garcia-Martos et al 1996). The presence of A. pullulans in indoor air can intensify asthma symptoms (Niedorzytko et al 2007) or lead to the development of pulmonary hypersensitivity to its spores (Temprano et al 2007). …”

Section: Discussionmentioning

confidence: 99%

Yeast-like fungi isolated from indoor air in school buildings and the surrounding outdoor air

Ejdys

Michalak²,

Szewczyk

2013

Acta Mycol

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A total of 111 isolates of yeast-like fungi and yeasts belonging to 40 species of 19 genera were identified in indoor air and outdoor air. Only one species, Kluyveromyces marxianus, was recorded in both types of air and seasons (spring and autumn). Kluyveromyces lactis and Yarrowia lipolytica, a species having the greatest symbiotic abilities, dominated in indoor air and outdoor air, respectively. Intensely used rooms, especially those with limited access of air, have the broadest range of species of yeast-like fungi. A comparison of both habitats shows that school rooms pose a greater epidemiological risk of yeast-like infections than outdoor air. The indoor as well as outdoor mycobiota undergoes phenological changes although it is determined by other biotic and abiotic factors.

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“…Состояние также может быть хроническим и опосредованным лимфоцитами. Хроническое состояние рентгенографически характеризуется ретикулонодулярными инфильтратами в легких [14][15][16].…”

Section: обзорные и оригинальные статьиunclassified

Aureobasidium pullulans place among human pathogens opportunistic infections (literature review)

Багирова¹

2018

Lab. sluzh.

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Aureobasidium pullulans-сапрофитный гриб, который широко распространен в окружающей среде и активно используется в различных промышленных технологиях. Как и многие сапрофитные грибы, при определенных условиях A. pullulans может вызывать оппортунистические микозы у человека. Глубокий микоз, обусловленный A. pullulans, зачастую трудно поддается лечению, стандартная терапия отсутствует. Тактика ведения таких пациентов основана на данных in vitro в экспериментах на животных, на клиническом опыте, полученном, в основном, при экспертной оценке описанных клинических случаев.

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Hypersensitivity pneumonitis secondary to residential exposure to Aureobasidium pullulans in 2 siblings

Cited by 23 publications

References 20 publications

Hypersensitivity pneumonitis: lessons for diagnosis and treatment of a rare entity in children

Hypersensitivity pneumonitis: lessons for diagnosis and treatment of a rare entity in children

Yeast-like fungi isolated from indoor air in school buildings and the surrounding outdoor air

Aureobasidium pullulans place among human pathogens opportunistic infections (literature review)

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