Hypersensitivity pneumonitis in a metal‐working environment

Hodgson, Michael; Bracker, Anne; Yang, Chin S.; Storey, Eileen; Jarvis, Bruce J.; Milton, Donald K.; Lummus, Zana L.; Bernstein, David I.; Cole, Solon

doi:10.1002/ajim.1061

Cited by 74 publications

(51 citation statements)

References 45 publications

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“…This leads to selection of niche organisms such as mycobacteria. Outbreaks of lung disease characterized as HP have been observed among workers exposed to MWF over the past decade (1)(2)(3)(4)(5). Many of these outbreaks were linked to MWF containing mycobacteria.…”

Section: Discussionmentioning

confidence: 99%

Metalworking Fluid with Mycobacteria and Endotoxin Induces Hypersensitivity Pneumonitis in Mice

Thorne

Adamcakova‐Dodd

Kelly

et al. 2006

Am J Respir Crit Care Med

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Section: Discussionmentioning

confidence: 99%

Metalworking Fluid with Mycobacteria and Endotoxin Induces Hypersensitivity Pneumonitis in Mice

Thorne

Adamcakova‐Dodd

Kelly

et al. 2006

Am J Respir Crit Care Med

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“…Since the first reports (5,27), most described cases of MWFrelated HP have been in the U.S. automotive industry (4,18,20,24,28,32,37,42,56). The first European case clusters were recently reported in automotive plants in Great Britain (8) and in France (41).…”

mentioning

confidence: 99%

Factors Influencing the Microbial Composition of Metalworking Fluids and Potential Implications for Machine Operator's Lung

Murat

Grenouillet

Reboux

et al. 2012

Appl Environ Microbiol

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Hypersensitivity pneumonitis, also known as "machine operator's lung" (MOL), has been related to microorganisms growing in metalworking fluids (MWFs), especially Mycobacterium immunogenum. We aimed to (i) describe the microbiological contamination of MWFs and (ii) look for chemical, physical, and environmental parameters associated with variations in microbiological profiles. We microbiologically analyzed 180 MWF samples from nonautomotive plants (e.g., screw-machining or metalcutting plants) in the Franche-Comté region in eastern France and 165 samples from three French automotive plants in which cases of MOL had been proven. Our results revealed two types of microbial biomes: the first was from the nonautomotive industry, showed predominantly Gram-negative rods (GNR), and was associated with a low risk of MOL, and the second came from the automotive industry that was affected by cases of MOL and showed predominantly Gram-positive rods (GPR). Traces of M. immunogenum were sporadically detected in the first type, while it was highly prevalent in the automotive sector, with up to 38% of samples testing positive. The use of chromium, nickel, or iron was associated with growth of Gram-negative rods; conversely, growth of Gram-positive rods was associated with the absence of these metals. Synthetic MWFs were more frequently sterile than emulsions. Vegetable oil-based emulsions were associated with GNR, while mineral ones were associated with GPR. Our results suggest that metal types and the nature of MWF play a part in MWF contamination, and this work shall be followed by further in vitro simulation experiments on the kinetics of microbial populations, focusing on the phenomena of inhibition and synergy.

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“…Previous studies focusing on specific workplaces, mainly in the automobile industry, have linked exposure to metalworking fluids with respiratory symptoms, lung function changes, and occupational asthma, bronchitis or allergic alveolitis (10)(11)(12)(13)(14)(15)(16)(17)(18)(19)(20). Most of these studies were conducted in North America.…”

mentioning

confidence: 99%

Respiratory symptoms and conditions related to occupational exposures in machine shops

Jaakkola¹,

Suuronen²,

Luukkonen³

et al. 2009

Scand J Work Environ Health

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Hypersensitivity pneumonitis in a metal‐working environment

Abstract: Lung disease in environments with water-based aerosols may be more common than usually recognized. Patients with HP often present with only subtle abnormalities and may be missed if multiple clinical abnormalities are required to document disease.

Cited by 74 publications

References 45 publications

Metalworking Fluid with Mycobacteria and Endotoxin Induces Hypersensitivity Pneumonitis in Mice

Metalworking Fluid with Mycobacteria and Endotoxin Induces Hypersensitivity Pneumonitis in Mice

Factors Influencing the Microbial Composition of Metalworking Fluids and Potential Implications for Machine Operator's Lung

Respiratory symptoms and conditions related to occupational exposures in machine shops

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