Hypersensitive and selective biosensing based on microfiber interferometry and molecular imprinted nanoparticles

Shrivastav, Anand M.; Sharma, Gaurav; Jha, Rajan

doi:10.1016/j.bios.2019.111347

Cited by 33 publications

(16 citation statements)

References 44 publications

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“…The efficient performance of the probe depends on several key parameters of the probe, such as template concentration, amount of solvent, the concentration of the cross‐linking agent, polymerization temperature, and time. [ 22 ] Among these, the template concentration and the cross‐linking agent concentration influence most on the probe performance. The concentration of the template determines the number of imprinted sites on the polymer surface.…”

Section: Resultsmentioning

confidence: 99%

Artificial Receptor‐Based Optical Sensors (AROS): Ultra‐Sensitive Detection of Urea

Gorai

Singh

Jha

2021

Advanced Photonics Research

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The combined approach of optical fiber interferometry with molecular imprinting technology has shown a tremendous potential for developing a specific and sophisticated bio‐detection system with high degree of resolution and sensitivity. However, the specificity limitation of the fiber optic sensors renders them unsuitable for several key applications. Molecular imprinted polymer (MIP), an indispensable artificial molecular receptor with a complementary structure and functionality for the target analyte, possesses the ability to overcome the limitations of specificity. Therefore, a new class of artificial receptor‐based optical sensors (AROS) constructed from an optical fiber interferometer integrated with artificial MIP for selective and ultrasensitive sensing of urea is demonstrated. The sensor device shows an unprecedented sensitivity of 0.584 × 1011 nm m −1 and a lower detection limit of 17.1 fM with a wide dynamic range of 10−11–10−4 m. This demonstration of an ultrasensitive, selective, and accurate AROS system is bound to find potential applications that requires remote sensing in harsh environmental conditions with large fluctuations in the temperature, pressure, and humidity.

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Section: Resultsmentioning

confidence: 99%

Artificial Receptor‐Based Optical Sensors (AROS): Ultra‐Sensitive Detection of Urea

Gorai

Singh

Jha

2021

Advanced Photonics Research

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“…In this process, initially, 4 mM of p -cresol is dissolved into 40 mL of dry acetonitrile (AcN) along with 1.012 mL of methacrylic acid (MAA). After that, the sample mixture is sonicated for 120 min . The p -cresol molecules bind with MAA through hydrogen bonding and make a pre-polymerized complex assembly.…”

Section: Fabrication Of the Sensing Probementioning

confidence: 99%

Molecular Imprinting Polymer Nanoparticles Coupled with an Optical Sensor for Sensitive and Label-Free Detection of p-Cresol

Gorai

Mizuno

Kumar

et al. 2023

ACS Appl. Nano Mater.

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Selective detection of toxic pollutants present in water has been a severe challenge to the scientific community for a long time. The noble integration of optical fiber-based interferometry with a bio-recognizing element molecular imprinting polymer (MIP) exhibits a promising technique for selective and susceptible biochemical detection. Here, we report a compact, stable, reproducible, and label-free optical sensor using a combined approach of photonic crystal fiber (PCF)-based modal interferometry and MIP nanoparticles (MIP-NPs) for selective detection of water pollutant p-cresol with an extremely low limit of detection (LOD). The MIP-NPs having a greater surface-to-volume aspect ratio allows more target analytes to bind. The sensor immobilized with MIP-NPs shows unprecedented sensitivity of 1.865 × 108 nm/M with specific and repeatable detection performance for a broad dynamic detection range of 10–8–10–3 M. The sensor offers a remarkable detection ability of as low as 1.55 nM concentrations of p-cresol in the aqueous medium, for water quality monitoring. Fast response, high resolution, compact size, label-free broad detection range, and selective reusable performance of the proposed sensor exhibit potential for board practical utilizations, including medical sectors, online and remote biosensing, and water resource monitoring.

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“…The evanescent field associated with the cladding mode becomes highly influenced by the medium surrounding the taper and causes a phase shift. A biosensor has been developed based on MZI through the tapered fiber by the coatings of specific layer over the tapered region of SMF [68]. Additionally, the splicing of several specially designed optical fibers with SMF, also produces MZI like SMF-multimode fiber (MMF)-SMF [69], SMF-photonic crystal fiber (PCF)-SMF [70], and SMF-hollow core fiber (HCF)-SMF structure [71].…”

Section: Interference Based Optical Fiber Sensorsmentioning

confidence: 99%

Optical Biomedical Diagnostics Using Lab-on-Fiber Technology: A Review

2022

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Point-of-care and in-vivo bio-diagnostic tools are the current need for the present critical scenarios in the healthcare industry. The past few decades have seen a surge in research activities related to solving the challenges associated with precise on-site bio-sensing. Cutting-edge fiber optic technology enables the interaction of light with functionalized fiber surfaces at remote locations to develop a novel, miniaturized and cost-effective lab on fiber technology for bio-sensing applications. The recent remarkable developments in the field of nanotechnology provide innumerable functionalization methodologies to develop selective bio-recognition elements for label free biosensors. These exceptional methods may be easily integrated with fiber surfaces to provide highly selective light-matter interaction depending on various transduction mechanisms. In the present review, an overview of optical fiber-based biosensors has been provided with focus on physical principles used, along with the functionalization protocols for the detection of various biological analytes to diagnose the disease. The design and performance of these biosensors in terms of operating range, selectivity, response time and limit of detection have been discussed. In the concluding remarks, the challenges associated with these biosensors and the improvement required to develop handheld devices to enable direct target detection have been highlighted.

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Hypersensitive and selective biosensing based on microfiber interferometry and molecular imprinted nanoparticles

Cited by 33 publications

References 44 publications

Artificial Receptor‐Based Optical Sensors (AROS): Ultra‐Sensitive Detection of Urea

Artificial Receptor‐Based Optical Sensors (AROS): Ultra‐Sensitive Detection of Urea

Molecular Imprinting Polymer Nanoparticles Coupled with an Optical Sensor for Sensitive and Label-Free Detection of p-Cresol

Optical Biomedical Diagnostics Using Lab-on-Fiber Technology: A Review

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