Hyperscalcemia of Thyrotoxicosis

Hypercalcaemia in thyrotoxicosis with and without hyperparathyroidism

“…Barium Torsti & Lamberg (1963). However, Baxter & Bondy (1966), on reviewing the records of 302 hyperthyroid patients, found nineteen to have hypercalcaemia, in only two of these due to associated hyperparathyroidism. Adams et al (1967) have shown that the mean serum calcium of hyperthyroid patients tends to be higher than that of normal subjects, matched for sex and age; and the serum ionized calcium is also higher in hyperthyroid patients (Frizel, Malleson & Marks, 1967), possibly because of a tendency to hypoalbuminaemia (Man, Gildea & Peters, 1940).…”

Development of Hypercalcemic Crisis in a Graves' Hyperthyroid Patient Associated with Central Diabetes Insipidus.

“…Howver, the incidence of hypercalcemia with greater than 12.0 mg/dl, is very low (1-3) because of hypercalciuria due to the decrease in serum PTH level (3,5,6) and the decrease of intestinal calcium absorption due to the decrease in serum 1,25-dihydroxy vitamin D3 [1,25(OH) 2D3] level (5). It has been also known that hypercalcemia induces a nephrogenic diabetes insipidus (DI)-like state (7).…”

“…It has been well known that hypercalcemia (1-3) due to direct stimulation of bone resorption by thyroid hormoneexcess (4) occurs in hyperthyroidism and its association is as frequent as 16 to 27% (1)(2)(3).…”

Severe Hypercalcaemia Mimicking Primary Hyperparathyroidism in the Context of Thyrotoxicosis: A Case Report

“…Firstly, a severe and symptomatic hypercalcemia associated with thyrotoxicosis, demonstrated on two separate occasions. This degree of hypercalcemia (3.34 mmol/L) is the most significant we have seen documented in the literature [4][5][6]. It was clear from her presentation that she had symptoms of both hypercalcemia and thyrotoxicosis; however, this may not always be clear-cut, therefore it is important to consider hyperthyroidism in patients with predominant symptoms of hypercalcemia.…”