Hyperreactivity of Platelets to Serotonin (5-Hydroxytryptamine) in Patients with Cardiovascular Diseases

Cree, J. De; Roels, Vera; Verhaegen, H.

doi:10.2165/00003495-198800361-00015

Cited by 8 publications

(4 citation statements)

References 9 publications

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“…High plasma cholesterol, a known risk factor for cardiovascular disease, may also in¯uence platelet reactivity and the thrombotic phenomena, and hence in¯uence the progression of the atheromatosus plaque and its complications. De Cree Â et al [31] demonstrated that platelets from hypercholesterolemic patients or patients affected of coronary disease had more sensitivity to 5-hydroxytryptamine (5HT) in in vitro aggregation studies. In an experimental model of homozygous hypercholesterolemia in rabbits we had previously shown that platelet adhesion and thrombus formation on the vessel wall was increased, indicating a prothrombotic risk [32].…”

Section: Discussionmentioning

confidence: 99%

“…De Creé et al . [ 31] demonstrated that platelets from hypercholesterolemic patients or patients affected of coronary disease had more sensitivity to 5‐hydroxytryptamine (5HT) in in vitro aggregation studies. In an experimental model of homozygous hypercholesterolemia in rabbits we had previously shown that platelet adhesion and thrombus formation on the vessel wall was increased, indicating a pro‐thrombotic risk [ 32].…”

Section: Discussionmentioning

confidence: 99%

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Effect of gemfibrozil on peripheral atherosclerosis and platelet activation in a pig model of hyperlipidemia

Royo

Alfón

Berrozpe

et al. 2000

Eur J Clin Investigation

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Effect of gemfibrozil on peripheral atherosclerosis and platelet activation in a pig model of hyperlipidemia

Royo

Alfón

Berrozpe

et al. 2000

Eur J Clin Investigation

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“…Serotonin (5-HT) is one of a variety of humoral factors capable of activating blood platelets [1,2] and may play a role in various cardiovascular diseases, including certain ischemic cardiac syndromes [3,4]. Recent evidence suggests that platelet aggregation and the resultant release of serotonin at sites of coronary stenosis may be important mechanistic components of unstable angina and acute myocardial infarction [5].…”

mentioning

confidence: 99%

“…The 5-HT 2 antagonist ketanserin is one of the drugs shown to be capable of inhibiting induced platelet aggregation in patients with cardiovascular diseases [3,4], as well as abolishing cyclic flow reductions in the abovementioned canine model [6][7][8].…”

mentioning

confidence: 99%

Effect of encainide, ODE, MODE, and flecainide on ADP/5-HT Induced platelet aggregation and in the anesthetized dog coronary artery stenosis-occlusion model of intravascular thrombosis

Fleming

Buchanan

Yocca

et al. 1991

Cardiovasc Drug Ther

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Encainide is a class 1C antiarrhythmic agent that is indicated for the treatment of life-threatening arrhythmias, such as sustained ventricular tachycardia. Furthermore, encainide possesses a moderate degree of antiserotonin activity, which was quantitated in this present study by determining displacement of [3H]spiperone binding from rat cortical 5-HT2 binding sites. The Ki for encainide in this model was 66.1 nM, compared to 2.6 nM for ketanserin. Two encainide metabolites, ODE and MODE, were also active, but were weaker than encainide. Additionally, these agents were found to inhibit platelet aggregation induced in vitro in human platelet-rich plasma by the combination of ADP and serotonin. In view of the fact that serotonin is one of a variety of humoral factors capable of activating blood platelets and has been recently implicated as playing a role in certain thrombotic syndromes, encainide, along with its two principal human metabolites, ODE and MODE, and another class 1C antiarrhythmic, flecainide, were evaluated in an in vivo model of intravascular thrombosis. Intraduodenal doses of 1 mg/kg of either encainide, ODE, or MODE significantly inhibited thrombosis in a canine model of coronary artery stenosis-occlusion.

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5-Hydroxytryptamine2 (5-HT2) structure-function relationships of the nitro and amino phenylpiperazines on intact human platelets

Britt

Redpath

Gonias

1989

Biochemical Pharmacology

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Hyperreactivity of Platelets to Serotonin (5-Hydroxytryptamine) in Patients with Cardiovascular Diseases

Cited by 8 publications

References 9 publications

Effect of gemfibrozil on peripheral atherosclerosis and platelet activation in a pig model of hyperlipidemia

Effect of gemfibrozil on peripheral atherosclerosis and platelet activation in a pig model of hyperlipidemia

Effect of encainide, ODE, MODE, and flecainide on ADP/5-HT Induced platelet aggregation and in the anesthetized dog coronary artery stenosis-occlusion model of intravascular thrombosis

5-Hydroxytryptamine2 (5-HT2) structure-function relationships of the nitro and amino phenylpiperazines on intact human platelets

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