Hyperreactio luteinalis associated with fetal hyperandrogenism and cystic hygroma

Abstract

A 23‐year‐old woman with a gestational age of 17 weeks presented with abdominal pain. The ultrasound showed maternal hyperreactio luteinalis with fetal cystic hygroma. After termination of pregnancy, the female fetus showed masculinization features with muscular hypertrophy. The hyperreactio luteinalis regressed under hormonal suppression therapy.

Hyperreactio luteinalis and follicle-stimulating hormone receptor gene activation mutations: A case report

“…Elevated thyroid-stimulating hormone levels may contribute to the development of HL through cross-reactivity with human chorionic gonadotropin and follicle-stimulating hormone receptors. Ghassan et al suggested that luteal hyperresponsiveness is associated with fetal hyperandrogenemia and cystic hydrops [ 5 ]. In the present case, the fetus was normal, and the mother did not show signs of hyperandrogenemia.…”