Hyperprolactinemia is associated with a high prevalence of serum autoantibodies, high levels of inflammatory cytokines and an abnormal distribution of peripheral B-cell subsets

Liu, Yaoyang; Zhang, Zhiguo; Jin, Qianmei; Yang, Lei; Kang, Zijian; Huo, Yongbao; He, Zhengwen; Xu, Feng; Yin, Jian; Wu, Xinyu; Wang, Huaizhou; Xu, Huji

doi:10.1007/s12020-019-01896-y

Cited by 16 publications

(7 citation statements)

References 34 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Moreover, pro-inflammatory cytokines stimulate pituitary PRL secretion [140] and lymphocytes express dopamine receptors (predominantly D4R and D5R) modulating local PRL production and secretion [8]. A recent case control study by Liu et al [141] of 202 patients with hyperprolactinaemia found that a significantly higher proportion of hyperprolactinaemic patients had at least one detectable autoantibody, as well as higher levels of IL-4 and IL-6 compared to healthy controls.…”

Section: Hyperprolactinaemia and Autoimmunitymentioning

confidence: 99%

Hyperprolactinaemia

Samperi

Lithgow

Karavitaki

2019

JCM

View full text Add to dashboard Cite

Hyperprolactinaemia is one of the most common problems in clinical endocrinology. It relates with various aetiologies (physiological, pharmacological, pathological), the clarification of which requires careful history taking and clinical assessment. Analytical issues (presence of macroprolactin or of the hook effect) need to be taken into account when interpreting the prolactin values. Medications and sellar/parasellar masses (prolactin secreting or acting through "stalk effect") are the most common causes of pathological hyperprolactinaemia. Hypogonadism and galactorrhoea are well-recognized manifestations of prolactin excess, although its implications on bone health, metabolism and immune system are also expanding. Treatment mainly aims at restoration and maintenance of normal gonadal function/fertility, and prevention of osteoporosis; further specific management strategies depend on the underlying cause. In this review, we provide an update on the diagnostic and management approaches for the patient with hyperprolactinaemia and on the current data looking at the impact of high prolactin on metabolism, cardiovascular and immune systems.

show abstract

Section: Hyperprolactinaemia and Autoimmunitymentioning

confidence: 99%

Hyperprolactinaemia

Samperi

Lithgow

Karavitaki

2019

JCM

View full text Add to dashboard Cite

show abstract

“…Prolactin (PRL) is a pro‐inflammatory hormone implicated in the development of autoimmune diseases 1 . Hyperprolactinemia has been associated with endothelial dysfunction and insulin resistance, which are precursors of atherosclerosis 2,3 . The neutrophil/lymphocyte ratio (NLR) is a potential marker for detecting inflammation in cardiac and non‐cardiac disorders 4 .…”

Section: Variables Group 1 Normal Prolactin (N = 537) Group 2 High...mentioning

confidence: 99%

Correlation of prolactin levels with the neutrophil/lymphocyte ratio

Carranza-Lira

Quezada

López

et al. 2021

Intl J Gynecology & Obste

View full text Add to dashboard Cite

show abstract

“…[ 30 ] Moreover, the hyperprolactinaemia resulting in formation of auto‐antibodies further elevates the serum levels of IL‐4 and IL‐6, and BND cells. [ 31 ] Genetic factors : RA is about 12–15% more common in monozygotic twins as compared to 1% for the general population, which is approximately 2–5% indicating polymorphism in signalling transducers and STAT% in sibling. [ 32,33 ] The heritability of rheumatoid arthritis or genetic link is approximately 40–65% associated due to the mutation of human leucocyte antigen (HLA) gene and other immune‐ as well as inflammatory‐like interleukin (IL‐4, IL‐10) genes which are responsible for the risk of rheumatoid arthritis.…”

Section: Aetiological Factors Of Rheumatoid Arthritismentioning

confidence: 99%

“…[ 91 ] The bioactive phytochemical constituents of this plant include berberine, umbellatine, baluchistanamine, karakoramine, gilgitine, jhelumine, punjabine, sindamine, chinabine, berbamine, β‐sitosterol, 4,4‐dimethylhexadeca‐3‐ol and 3‐(4′‐(6‐methylbutyl) phenyl) propan‐1‐ol. [ 31,92–96 ] Berberis lycium crude extract has been used for both acute and chronic inflammation in mice. It acts by the inhibition of prostaglandin synthesis in carrageenan‐induced inflammation, whereas inhibition of phospholipase A2 was reported in xylene‐induced inflammation.…”

Section: The Various Herbal Plants Used In the Treatment Of Rheumatoimentioning

confidence: 99%

Medicinal plants used against various inflammatory biomarkers for the management of rheumatoid arthritis

Singh

Mahajan

et al. 2020

Journal of Pharmacy and Pharmacology

View full text Add to dashboard Cite

Objectives Rheumatoid arthritis is a chronic autoimmune disease manifested clinically by polyarthralgia associated with joint dysfunction triggering the antibodies targeting against the self‐neoepitopes determined by autoimmune responses associated with chronic arthritic attacks. The activation of macrophages and other defence cells in response to self‐epitopes as biomarkers in RA provides a better understanding of pathogenesis of disease and has led to the development of novel therapeutic approaches acting as potent inhibitors of these cells. Key findings The current review retrieved the various medicinal plants possessing an active phytoconstituents with anti‐inflammatory and antioxidant properties, which tends to be effective alternative approach over the synthetic drugs concerned with high toxic effects. The current available literature provided an evident data concluding that the active constituents like fatty acids, flavonoids, terpenes and sesquiterpene lactones attenuate the RA symptoms by targeting the inflammatory biomarkers involved in the pathogenesis of RA. Summary Despite the various synthetic treatment approaches targeting immune cells, cytokines improved the quality of life but still the drug management is challenging due to toxic and chronic teratogenic effects with anti‐arthritic drugs. The current review has elaborated the selected traditionally used herbal medicinal plants with phytoconstituents possessing anti‐inflammatory activity by suppressing the inflammatory biomarkers with lesser side effects and providing the future exploration of natural drug therapy for rheumatoid arthritis.

show abstract

Hyperprolactinemia is associated with a high prevalence of serum autoantibodies, high levels of inflammatory cytokines and an abnormal distribution of peripheral B-cell subsets

Cited by 16 publications

References 34 publications

Hyperprolactinaemia

Hyperprolactinaemia

Correlation of prolactin levels with the neutrophil/lymphocyte ratio

Medicinal plants used against various inflammatory biomarkers for the management of rheumatoid arthritis

Contact Info

Product

Resources

About