Hyperprolactinemia in some Ménière patients even in the absence of incapacitating vertigo

Falkenius-Schmidt, Karolina; Rydmarker, S; Horner, Kathleen C.

doi:10.1016/j.heares.2004.11.015

Cited by 11 publications

(6 citation statements)

References 33 publications

(33 reference statements)

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“…Previous findings have suggested a potential role of Prl in inner ear function. For example, a hyperprolactenemia has been reported in patients presenting with an inner ear dysfunction [52] , [53] . These observations were followed by a study demonstrating that hyperprolactenemia induced by a long-term estrogen treatment in guinea pig led to conductive hearing loss probably linked to an inner ear ionic homeostasis defect [54] .…”

Section: Discussionmentioning

confidence: 99%

Transcriptomic Analysis of the Developing and Adult Mouse Cochlear Sensory Epithelia

et al. 2012

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The adult mammalian cochlea lacks regenerative ability and the irreversible degeneration of cochlear sensory hair cells leads to permanent hearing loss. Previous data show that early postnatal cochlea harbors stem/progenitor-like cells and shows a limited regenerative/repair capacity. These properties are progressively lost later during the postnatal development. Little is known about the genes and pathways that are potentially involved in this difference of the regenerative/repair potentialities between early postnatal and adult mammalian cochlear sensory epithelia (CSE). The goal of our study is to investigate the transcriptomic profiles of these two stages. We used Mouse Genome 430 2.0 microarray to perform an extensive analysis of the genes expressed in mouse postnatal day-3 (P3) and adult CSE. Statistical analysis of microarray data was performed using SAM (Significance Analysis of Microarrays) software. We identified 5644 statistically significant differentially expressed transcripts with a fold change (FC) >2 and a False Discovery Rate (FDR) ≤0.05. The P3 CSE signature included 3,102 transcripts, among which were known genes in the cochlea, but also new transcripts such as, Hmga2 (high mobility group AT-hook 2) and Nrarp (Notch-regulated ankyrin repeat protein). The adult CSE overexpressed 2,542 transcripts including new transcripts, such as Prl (Prolactin) and Ar (Androgen receptor), that previously were not known to be expressed in the adult cochlea. Our comparative study revealed important genes and pathways differentially expressed between the developing and adult CSE. The identification of new candidate genes would be useful as potential markers of the maintenance or the loss of stem cells and regenerative/repair ability during mammalian cochlear development.

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Section: Discussionmentioning

confidence: 99%

Transcriptomic Analysis of the Developing and Adult Mouse Cochlear Sensory Epithelia

et al. 2012

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“…Although experimental chronic estrogen-induced hyperprolactinemia in the guinea pig may not represent all categories of hyperprolactinemia in humans, the data allow us to speculate that hyperprolactinemia observed by us earlier, in some patients with Ménière disease (30,49), might have played some causative role in the symptoms. In fact, otosclerosis and Ménière disease can coexist, although the causal relationship remains controversial (84,87).…”

Section: Discussionmentioning

confidence: 71%

“…Recently, our group (49) investigated stress hormones in patients with Ménière disease and, unexpectedly, revealed several cases of Ménière disease with marked hyperprolactinemia and subsequent MRI-confirmed pituitary adenoma. A further study in Sweden confirmed the association of hyperprolactinemia in several patients with Ménière disease, and one had a pituitary adenoma (30). The data are particularly intriguing because hyperprolactinemia has never before been described in this pathology; furthermore, clinical diagnostic schema for hyperprolactinemia do not include any otological pathological features (6).…”

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confidence: 99%

Experimental estrogen-induced hyperprolactinemia results in bone-related hearing loss in the guinea pig

Horner¹,

Cazals²,

Guieu³

et al. 2007

American Journal of Physiology-Endocrinology and Metabolism

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Our group (Horner KC, Guieu R, Magnan J, Chays A, Cazals Y. Neuropsychopharmacology 26: 135–138, 2002) has earlier described hyperprolactinemia in some patients presenting inner ear dysfunction. However, in that study, it was not possible to determine whether hyperprolactinemia was a cause or an effect of the symptoms. To investigate the effect of hyperprolactinemia on inner ear function, we first developed a model of hyperprolactinemia in estrogen-primed Fischer 344 rats and then performed functional studies on pigmented guinea pigs. Hyperprolactinemia induced, after 2 mo, a hearing loss of ∼30–40 dB across all frequencies, as indicated by the compound action potential audiogram. During the 3rd mo, the hearing loss continued to deteriorate. The threshold shifts were more substantial in males than in females. Observations under a dissection microscope revealed bone dysmorphology of the bulla and the cochlea. Light microscopy observations of cryostat sections confirmed bone-related pathology of the bony cochlear bulla and the cochlear wall and revealed morphopathology of the stria vascularis and spiral ligament. Scanning electron microscopy revealed loss of hair cells and stereocilia damage, in particular in the upper three cochlear turns and the two outermost hair cell rows. The data provide the first evidence of otic capsule and hair cell pathology associated with estrogen-induced prolonged hyperprolactinemia and suggest that conditions such as pregnancy, anti-psychotic drug treatment, aging, and/or stress might lead to similar ear dysfunctions.

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“…A subset of Ménière's patients can also present otosclerosis (Paparella et al, 1984;Shea et al, 1994;Sismanis et al, 1986;Yoon et al, 1990). While hyperprolactinemia has been reported in some patients (Falkenius-Schmidt et al, 2005;Horner et al, 2002), there is no data to link hyperprolactinemia in some Ménière-like patients to otosclerosis in those patients. One clue is provided by estrogen-induced hyperprolactinemia which was reported to provoke hearing loss and otic capsule dysmorphology in guinea pigs (Horner et al, 2007).…”

Section: Prolactin Is Linked To Other Labyrinthine Pathologiesmentioning

confidence: 99%

Hyperprolactinemia in some Ménière patients even in the absence of incapacitating vertigo

Cited by 11 publications

References 33 publications

Transcriptomic Analysis of the Developing and Adult Mouse Cochlear Sensory Epithelia

Transcriptomic Analysis of the Developing and Adult Mouse Cochlear Sensory Epithelia

Experimental estrogen-induced hyperprolactinemia results in bone-related hearing loss in the guinea pig

The effect of sex hormones on bone metabolism of the otic capsule – an overview

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