Hyperprolactinemia due to pituitary metastasis: A case report

Liu, Chunyang; Wang, Yübo; Zhu, Hongxia; You, Jinliang; Liu, Zhuang; Zhang, Xianfeng

doi:10.12998/wjcc.v9.i1.190

Cited by 6 publications

(5 citation statements)

References 13 publications

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“…Kelestimur reports on a patient with Sheehan's syndrome and hyperprolactinemia, in which the hyperprolactinemia disappeared after the reduction of thyroxine to a suboptimal level [33]. A case report describing a patient with pituitary metastasis indicates that prolactin levels can be elevated during panhypopituitarism with a poor prognosis [34]. Oxytocin is also known to lead to prolactin secretion, which could explain the elevated prolactin level in our patient, although oxytocin was likely administered in the other cases included in this review [35].…”

Section: Discussionmentioning

confidence: 78%

Acute Sheehan’s syndrome manifesting initially with diabetes insipidus postpartum: a case report and systematic literature review

Olmes

Solomayer

Radosa

et al. 2021

Arch Gynecol Obstet

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Purpose Acute Sheehan’s syndrome is a rare, but potentially life-threatening, obstetric event that can be complicated by diabetes insipidus. Little information on the diagnosis and treatment of Sheehan’s syndrome with diabetes insipidus is available. We report on a 28-year-old patient who developed acute Sheehan’s syndrome with diabetes insipidus after giving birth, and on a systematic review of similar cases. Methods We performed a systematic review of the literature cataloged in PubMed and Google Scholar using the keywords “Sheehan syndrome” OR “Sheehan's syndrome” AND “diabetes insipidus” to identify relevant case reports published between 1990 and 2021. Eight Reports met the inclusion criteria (English-language abstracts available, onset in the puerperium, information about the day of the onset). Results In the present case, postpartum curettage was necessary to remove the residual placenta. The total amount of blood loss was severe (2500 ml). On the second day postpartal, the patient developed polyuria. Laboratory analysis revealed hypernatremia with increased serum osmolality and decreased urinary osmolality. Hormone analysis showed partial hypopituitarism involving the thyroid, corticotropic, and gonadotropic axes. The prolactin level was elevated. Brain magnetic resonance imaging showed pituitary gland infarction. Desmopressin therapy was initiated and resolved the polyuria. Hormone replacement therapy was administered. Four months later, the patient was well, with partial diabetes insipidus. The literature review indicated that this case was typical in terms of symptoms and disease onset. Most reported cases involve hypotension and peripartum hemorrhage, but some patients without hemorrhage also develop Sheehan’s syndrome. Elevated prolactin levels are uncommon and associated with poor prognosis in patients with Sheehan’s syndrome. Conclusion Acute Sheehan’s syndrome with diabetes insipidus involves nearly all pituitary hormone axes, indicating severe disease. Prolactin elevation could suggest that a case of Sheehan’s syndrome is severe.

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Section: Discussionmentioning

confidence: 78%

Acute Sheehan’s syndrome manifesting initially with diabetes insipidus postpartum: a case report and systematic literature review

Olmes

Solomayer

Radosa

et al. 2021

Arch Gynecol Obstet

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“…Autopsies have revealed that pituitary metastases account for nearly 5% of all pituitary metastases in sellar tumors. In surgical sections, less than 1% of all sellar tumors are associated with pituitary metastasis[ 3 ]. Pituitary metastases always metastasize from the lungs and breasts, accounting for 39.7% and 23.7% of cases, respectively[ 4 ].…”

Section: Discussionmentioning

confidence: 99%

Pituitary metastasis from lung adenocarcinoma: A case report

Wang,

Liu,

Chen

2024

World J Clin Cases

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BACKGROUND Pituitary gland metastasis is an unusual event, and pituitary metastasis from lung adenocarcinoma is extremely rare and associated with poor prognosis. To date, approximately 15 cases have been reported. CASE SUMMARY Here, we present the case of a 64-year-old woman with pituitary metastasis derived from lung adenocarcinoma, which was difficult to distinguish from other sellar tumors. The patient presented to the neurosurgery clinic with blurred vision and intermittent headache. During hospitalization, brain computed tomography (CT) and magnetic resonance imaging revealed a pituitary macroadenoma. Chest CT revealed irregular nodules in the basal segment of the lower lobe of the left lung, which were likely lung cancer. Positron emission tomography-CT revealed a carbohydrate metabolism tumor in the lungs and sellar region, which was considered malignant. Postoperative pathological examination of the sellar tumor revealed lung adenocarcinoma. CONCLUSION Excision of pituitary metastases combined with radiotherapy and chemotherapy should be a priority treatment for patients with pituitary metastasis.

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Section: Discussionmentioning

confidence: 99%

“…3 However, its prevalence in autopsy series was estimated to be higher and varies between 1% and 4% in patients with advanced cancer, which suggests that this entity may go undiagnosed. 4 The most common cancers metastasizing to the pituitary gland are breast and lung carcinomas responsible for more than half of all reported cases of PM. 3 Other primary cancers responsible for PM in 3%-5% of cases include kidney, prostate, and colon.…”

Section: Discussionmentioning

confidence: 99%

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Apoplexy in pituitary metastasis revealing a lung carcinoma

Maamri

Taieb

Ghorbel

et al. 2023

Respirology Case Reports

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Pituitary metastasis (PM) is an uncommon manifestation of systemic malignant tumours. It is the least common site of intracranial metastases. As PM has no clinical or radiological pathognomonic features, their diagnosis is challenging. Herein, we present a rare case of a PM unveiling lung cancer. A 60‐year‐old male with no medical history of malignancy was admitted with a sudden headache, retro‐orbital pain, and a severe loss of both eyes' visual acuity. After proper investigations and endoscopic resection of the sellar mass, the diagnosis was confirmed to be pituitary metastasis of lung carcinoma. PM can be the initial presentation of an otherwise unknown malignancy. Their diagnosis and management are complex and depend on many factors. Endoscopic surgical resection provides histopathological proof, helps with symptomatic relief, and improves the quality of life but has no effect on survival.

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Hyperprolactinemia due to pituitary metastasis: A case report

Cited by 6 publications

References 13 publications

Acute Sheehan’s syndrome manifesting initially with diabetes insipidus postpartum: a case report and systematic literature review

Acute Sheehan’s syndrome manifesting initially with diabetes insipidus postpartum: a case report and systematic literature review

Pituitary metastasis from lung adenocarcinoma: A case report

Apoplexy in pituitary metastasis revealing a lung carcinoma

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