Hyperprolactinemia contributes to reproductive deficit in male rats chronically administered PDE5 inhibitors (sildenafil and tadalafil) and opioid (tramadol)

Nna, Victor Udo; Akpan, U. P.; Osim, E. E.

doi:10.1016/j.apjr.2016.07.004

Cited by 10 publications

(8 citation statements)

References 21 publications

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“…Severe sperm deterioration may occur from the association of leucocytospermia, smoking, additional drugs abuse with tramadol. Several reports supported that sperm DNA integrity is compromised with any condition, drugs or injurious exposure to testicular tissue affecting spermatogenesis (Abedi, Nabi, Mangoli, & Talebi, ; Aziz, Sharma, Mahfouz, Jha, & Agarwal, ; Cui, Jing, Wu, Wang, & Li, ; Desai et al., ; Lackner, Agarwal, Mahfouz, du Plessis, & Schatzl, ; Mahfouz, Sharma, et al., ; Nna et al., ; Talebi, Sarcheshmeh, Khalili, & Tabibnejad, ).…”

Section: Discussionmentioning

confidence: 98%

“…Our findings agree with previous reports of tramadol association of hyperprolactinaemia and hypogonadotropic hypogonadism (Abdellatief, Elgamal, & Mohamed, ; Ahmed & Kurkar, ; Fitzgerald & Dinan, ; Osadolor & Omo‐Erhabor, ). The increased prolactin level could result from central vs peripheral tramadol effect on monoamine reuptake and its differential action on hypothalamic–pituitary axis, where it increases hypothalamic factors that increase prolactin contrast to little tramadol direct stimulation of lactotrophic cells in the pituitary (Nna, Akpan, & Osim, ; Osadolor & Omo‐Erhabor, ). Low androgen and increase hypothalamic release could explain hypergonadotropinaemia.…”

Section: Discussionmentioning

confidence: 99%

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Tramadol (opioid) abuse is associated with a dose- and time-dependent poor sperm quality and hyperprolactinaemia in young men

et al. 2018

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Tramadol, one of the most commonly abused drugs in Middle East, impacts spermatogenesis and disturbs reproductive hormones in animal studies. We aimed to investigate tramadol impact on sperm quality and on levels of testosterone, prolactin and gonadotropins, in tramadol abusers (n = 30) to age-matched control (n = 30). Abusers had significantly low percentages of sperm motility, normal forms and vitality compared with control (95% CI -40.7 to -19.3, -13.5 to -9.3 and -31.9 to -9.7 respectively). Hypoandrogenism (95% CI -4.5 to -2.8), hyperprolactinaemia (CI (95%) 4.9 to 9.4) and hypergonadotropinaemia (95% CI 2.9 to 7.2 for FSH and 2.0 to 7.8 for LH) were observed in tramadol abusers vs controls. Smokers (26 of 30), concurrently abusing other drugs (11 of 30) and asymptomatic leucocytospermic (15 of 30) patients subgroups significantly abused tramadol beyond 3 years (p = .02, <.001, = .03 respectively) and in excess >450 mg/day (p = .02, = .01, = .005 respectively). Progressive motility (a + b%) was significantly low in young men <25 years old (p = .03) subgroup. Tramadol abuse is associated with poor sperm quality, hyperprolactinaemia and hypergonadotropic hypogonadism. We recommend semen analysis for tramadol long-intakes, question sperm donors and follow-up studies to prevent and reverse tramadol-induced testicular damage.

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Section: Discussionmentioning

confidence: 98%

Section: Discussionmentioning

confidence: 99%

Tramadol (opioid) abuse is associated with a dose- and time-dependent poor sperm quality and hyperprolactinaemia in young men

et al. 2018

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“…On the other hand, TRAM showed a signi cant decrease in serum HDL, which is in agreement with the nding of Ahmed and Kurkar [39], who reported that TRAM administration decreased serum concentration of total cholesterol. This may be based on the action of TRAM on lipid metabolism or lipid peroxidation [40]. Nna et al [41] also reported that TRAM may inhibit cholesterol synthesis.…”

Section: Discussionmentioning

confidence: 99%

A novel model possible cardiotoxicity associated with administration of Boldenone and Tramadol, alone or in combination in Wistar rats

El-Shamarka

Asaad

Mowaad

et al. 2022

Preprint

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A risk of cardiotoxicity has been associated with the use of anabolic-androgenic steroids (AAS) and analgesics, several deaths have been attributed to such medications. This study investigates the effects on the heart of AAS; namely, boldenone (BOLD) and opioid analgesics; namely, tramadol (TRAM) given alone or in combination, for the first time. Forty adult male rats were randomly divided into four groups; (n = 10). Normal control group, BOLD (5 mg/kg, i.m.) per week, tramadol Hcl (TRAM) (20 mg/kg, i.p.) daily, and a combination of BOLD (5 mg/kg) and TRAM (20 mg/kg), respectively for two months. Those that received BOLD and TRAM alone and in combination showed deteriorated cardiac functions, elevated serum biochemical parameters (AST, CK) and deviations in lipid profiles, elevation in oxidative and inflammatory parameters (MDA, TNF-α & IL-1β) and decrease in GSH, up-regulated cardiac troponin I as well as distorted cardiac histopathological pictures. The current study elucidated the risk of administration of these drugs for sustained periods as well as the marked detrimental effects of using these drugs in combination.

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“…We hypothesise that the mechanism of physiological reproductive suppression, through the use of prolactin, may be the cause of the vast differences between breeders and non-breeders in females and to some extent males [49]. The physiological suppression in NMRs from elevated plasma prolactin levels [49,50] inherently suppresses reproductive hormones such as oestrogen, progesterone and testosterone [71,72]. BF NMRs possesses higher levels of both oestrogen, progesterone and testosterone [36,50].…”

Section: Discussionmentioning

confidence: 99%

Plasma oxidative stress in reproduction of two eusocial African mole-rat species, the naked mole-rat and the Damaraland mole-rat

2021

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One of the most prominent life-history trade-offs involves the cost of reproduction. Oxidative stress has been proposed to be involved in this trade-off and has been associated with reduced life span. There is currently an unclear relationship between oxidative cost and the reproduction-longevity trade-off. The current study, using a non-lethal and minimally invasive (only a single blood sample and no euthanasia) method, investigated whether an oxidative cost (oxidative stress) to reproduction would be apparent in two long-lived eusocial mole-rats, the naked mole-rat (NMR), Heterocephalus glaber, and the Damaraland mole-rat (DMR), Fukomys damarensis, where breeding colony members live longer than non-breeder conspecifics. We measured the direct redox balance in plasma by measuring the oxidative stress index (OSI) based on the ratio of total oxidant status and total antioxidant activity in breeders and non-breeders of both sexes, in the two species. NMR had significantly higher OSI between breeders and non-breeders of each sex, whereas DMR showed no significant differences except for total antioxidant capacity (TAC). The mode of reproductive suppression and the degree of reproductive investment in NMR may explain to some degree the redox balance difference between breeders and non-breeders. DMR show minimal physiological changes between breeders and non-breeders except for the mode of reproduction, which may explain some variations in TAC and TOS values, but similar OSI between breeders and non-breeders.

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Hyperprolactinemia contributes to reproductive deficit in male rats chronically administered PDE5 inhibitors (sildenafil and tadalafil) and opioid (tramadol)

Cited by 10 publications

References 21 publications

Tramadol (opioid) abuse is associated with a dose- and time-dependent poor sperm quality and hyperprolactinaemia in young men

Tramadol (opioid) abuse is associated with a dose- and time-dependent poor sperm quality and hyperprolactinaemia in young men

A novel model possible cardiotoxicity associated with administration of Boldenone and Tramadol, alone or in combination in Wistar rats

Plasma oxidative stress in reproduction of two eusocial African mole-rat species, the naked mole-rat and the Damaraland mole-rat

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