Hyperprolactinaemia and female reproductive function: what does the evidence say?

Hamoda, Haitham; Khalaf, Yakoub; Carroll, Paul

doi:10.1111/j.1744-4667.2012.00093.x

Cited by 12 publications

(7 citation statements)

References 31 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…This is consistent with the study done in Southern part of Ethiopia [13]. It has long been recognized that women who breastfeed their children for longer duration have a longer period of amenorrhea which results in post partum infecundability when compared to their counterparts [34]. During breastfeeding the receptors in the breast nipple are stimulated and this initiates a signal to the hypothalamus: a nerve center in the brain which in turn signals the pituitary gland which inhibits ovulation by reducing the release of gonadotrophic hormone needed for ovulation which results in post partum amenorrhea [35].…”

Section: Discussionsupporting

confidence: 91%

Short birth interval and associated factors among women of child bearing age in northern Ethiopia, 2016

et al. 2019

View full text Add to dashboard Cite

Background Short birth interval is known to have a negative effect on perinatal, neonatal and child health outcomes. In Ethiopia, 29% of births are short birth intervals at less than 24 months. Even though optimum birth spacing is considered as an essential factor for the health of women and their children, to the best of the authors’ knowledge studies conducted on short birth interval are insufficient to inform policy makers. Therefore, the aim of this study was to assess short birth interval and associated factors among women of child bearing age in Tigray, Ethiopia. Methods A community based cross-sectional study was conducted in Tselemti district among women of child bearing age from January 28 to February 28, 2016. Systematic sampling technique was used to select participants. Data were collected through face to face interviews and analyzed using SPSS version 20.0. Odds ratio along with 95% CI was computed to ascertain association between the outcome and predictor variables. A p -value of < 0.05 was considered as cut off point to assess significance of associations in the multivariable analysis. Results The overall prevalence of short birth interval among women of child bearing age was 187 (23.3%). Sub-optimum breastfeeding (AOR = 7.01; 95% CI: 3.64, 13.46), non-use of contraceptive (AOR = 2.44; 95% CI: 1.55, 3.82), being Muslim (AOR = 2.02; 95% CI: 1.20, 3.40) and not having desire to had the last child (AOR = 3.63; 95% CI: 2.23, 5.91) were factors associated with short birth interval. Conclusion Even though currently coverage of family planning use has increased, this study showed that short birth interval is still a concern for Ethiopian women due to factors such as: religion, suboptimum breastfeeding, unwanted pregnancy and non-use of contraceptives. Improving the accessibility and coverage of contraceptive use and involvement of religious leaders in family planning programs are essential strategies to be considered. Electronic supplementary material The online version of this article (10.1186/s12905-019-0776-4) contains supplementary material, which is available to authorized users.

show abstract

Section: Discussionsupporting

confidence: 91%

Short birth interval and associated factors among women of child bearing age in northern Ethiopia, 2016

et al. 2019

View full text Add to dashboard Cite

show abstract

“…Hyperprolactinemia is one of the causes of amenorrhea (absence of menstrual bleeding for three consecutive cycles) (67), and the mechanism suggested for amenorrhea is the suppression of the pulsatile GnRH (68). Also, increasing the level of prolactin can suppress the secretion of luteinizing hormone (LH) and inhibit ovulation in the menstrual cycle (69).…”

Section: Menstrual Cycle Disturbances In Women With Hyperprolactinemiamentioning

confidence: 99%

The Menstrual Disturbances in Endocrine Disorders: A Narrative Review

Naz

Dovom

Tehrani

2020

Int J Endocrinol Metab

View full text Add to dashboard Cite

Context: Menstrual cycle is considered the fifth vital sign among women. This study aimed to summarize the menstrual disturbances that were observed in different endocrine disorders. Evidence Acquisition: In this narrative review, relevant studies (up to December 2019) were searched based on the MeSH keywords diabetes, polycystic ovary syndrome, Cushing’s syndrome, thyroid dysfunction, hyperprolactinemia, menstrual cycle, uterine bleeding, and menstruation. Databases used for searching articles included Google Scholar, Scopus, PubMed, and Web of science for observational, experimental, and review studies. The findings discuss menstrual disturbances in endocrine disorders. Results: Endocrine disorders trigger the onset of menstrual disturbance across the reproductive lifespan of women. Endocrine glands (pituitary, pineal, thyroid, pancreases, adrenal, and ovaries) have a functional role in endocrine regulation of the menstrual cycle. According to available evidence, oligomenorrhea (cycle longer than 35 days) is the most common menstrual disturbance among endocrine disorders (thyrotoxicosis, hypothyroidism, polycystic ovary syndrome, Cushing’s syndrome, and diabetes), most of which impact the amount of menstrual bleeding. Complex endocrine pathways play an essential role in a women’s menstrual calendar. Conclusions: The menstrual cycle length and amount of bleeding are indicative of endocrine disorders. Further studies are needed to identify the unknowns about the association between endocrine disorders and the menstrual cycle.

show abstract

“…8,9 The study conducted by Hamoda et al, shows that Cabergoline is more effective than bromocriptin in lowering prolactin levels, with substantially fewer adverse effects and higher patient compliance. 10 Cabergoline has a very long elimination half-life and can, therefore, be administered once or twice a week. It has been shown to result in resumption of ovulation in 95% of cases.…”

Section: Discussionmentioning

confidence: 99%

Effectiveness of Cabergoline therapy in hyperprolactinemic infertility

Pitale¹

2019

Int J Reprod Contracept Obstet Gynecol

View full text Add to dashboard Cite

Background: Hyperprolactinemia may be associated with ovulatory dysfunction and resultant subfertility. Hyperprolactinemia affects the pulsatile release of GnRH, which in turn impairs the secretion of FSH and LH. It may also affect the endocrine activity of ovarian follicles, resulting into luteal phase defect and ovulatory dysfunction. Hyperprolactinemia may be associated with infertility in up to one-third of women undergoing infertility workup. Women with hyperprolactinemia are generally treated with dopamine receptor agonists to reduce serum prolactin levels and regularisation of menses. The aim of this study was to study the effectiveness of cabergoline therapy in hyperprolactinaemic infertility. Methods: This prospective study was performed from June 2017 to July 2018 in women with Hyperprolactinemic infertility attending the infertility clinic at INHS Patanjali. In this study, 20 women with hyperprolactinemic infertility who satisfied the inclusion and exclusion criteria were started on four week cabergoline therapy. The effectiveness of therapy was evaluated on the basis of normalization of prolactin levels, regularization of menses, reduction in galactorrhea, successful conception and adverse effects if any. Results: The women on Cabergoline therapy showed marked improvement in menstrual irregularity, near normal prolactin levels and reduced galactorrhea. After the four week Cabergoline therapy the frequency of galactorrhea and irregular menses was reduced in 8 (80%) and 14 (93.3) per cent, of women respectively. Successful conception was achieved in 17 (85%) women after regularization of menses with no any major adverse effects. Conclusions: This study shows the effectiveness of cabergoline therapy both on lowering the serum prolactin levels and successful Conception with no any major adverse effects. Cabergoline therapy is a cost effective and safe option in hyperprolactinaemic infertility.

show abstract

Hyperprolactinaemia and female reproductive function: what does the evidence say?

Cited by 12 publications

References 31 publications

Short birth interval and associated factors among women of child bearing age in northern Ethiopia, 2016

Short birth interval and associated factors among women of child bearing age in northern Ethiopia, 2016

The Menstrual Disturbances in Endocrine Disorders: A Narrative Review

Effectiveness of Cabergoline therapy in hyperprolactinemic infertility

Contact Info

Product

Resources

About