Hyperprogesteronism associated with adrenocortical tumours in two dogs

Farges, Anais; Crawford, Dave; da Silva, Carlos Adrega; Ramsey, Ian

doi:10.1002/vrc2.794

Cited by 3 publications

(1 citation statement)

References 28 publications

(63 reference statements)

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“…The PRDM is often observed during physiological diestrus but also may be secondary to pregnancy, ovarian remnant syndrome, and possible other ovarian diseases, or even iatrogenic due to the use of synthetic progestins [ 11 , 14 , 29 , 54 ]. Curiously, CDM secondary to P4-secreting corticoadrenal tumors is yet to be demonstrated in dogs [ 55 ]. Figure 2 depicts a chart of the progesterone-related conditions associated with PRDM in dogs.…”

Section: Estrus Cycle Effects On Insulin Sensitivitymentioning

confidence: 99%

Progesterone-Related Diabetes Mellitus in the Bitch: Current Knowledge, the Role of Pyometra, and Relevance in Practice

Pöppl,

Lopes,

Nogueira

et al. 2024

Animals

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Progesterone-related diabetes mellitus (PRDM) in dogs is known for its particular potential for diabetes remission. This narrative review aims to provide relevant detailed information on (1) the canine estrus cycle and its impact on canine diabetes mellitus (CDM) etiology and management, (2) the role of pyometra as a further cause of insulin resistance, and (3) useful individual therapeutic and preventive strategies. PRDM is recognized due to diestrus, exogenous progestogen exposure, pregnancy, and P4-production ovarian dysfunction. Pyometra represents additional inflammatory and septic negative influence on insulin sensitivity, and its diagnosis associated with CDM is therapeutically challenging. The estrus cycle’s hormone fluctuations seem to modulate peripheric insulin sensibility by influencing insulin receptor (IR) affinity and its binding capacity, as well as modulating tyrosine kinase activity. Pyometra was shown to negatively influence IR compensatory mechanisms to insulin resistance causing glucose intolerance. Spaying and pregnancy termination may cause diabetes remission in PRDM cases in a median time of 10 days (1–51). Pharmacological annulment of progesterone effects may benefit patients unable to undergo surgery; however, remission chances are virtually null. The ALIVE (Agreeing Language in Veterinary Endocrinology) project proposed new criteria for CDM diagnoses and subclinical diabetes recognition. These new concepts may increase the frequency of a PRDM diagnosis and, even more, its relevance. Spaying represents a preventive measure against pyometra and PRDM that should be individually assessed in light of its recognized benefits and harms.

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Section: Estrus Cycle Effects On Insulin Sensitivitymentioning

confidence: 99%

Progesterone-Related Diabetes Mellitus in the Bitch: Current Knowledge, the Role of Pyometra, and Relevance in Practice

Pöppl,

Lopes,

Nogueira

et al. 2024

Animals

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Subdiagnostic Cushing's syndrome in a Labrador retriever diagnosed with progesterone‐secreting adrenocortical neoplasia and late liver metastasis

Celliers,

Pazzi,

Mitchell

et al. 2024

Vet Record Case Reports

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A 5‐year‐old, neutered male Labrador retriever was presented for poor hair regrowth following clipping, lethargy, exercise intolerance, polyphagia, polydipsia, polyuria and heat‐seeking behaviour. A bradyarrhythmia due to a second‐degree atrioventricular block and poor cardiac contractility was found. On abdominal ultrasound, a left adrenal mass was detected, and a functional progesterone‐secreting tumour was diagnosed and confirmed on histopathology and electron microscopy. After the initiation of inodilator drug therapy and adrenalectomy with a subsequent decline in progesterone concentrations, the clinical signs resolved. The dog was represented 2 years later with similar clinical signs. The dog's progesterone concentrations were again elevated, and a metastatic liver mass was detected on abdominal ultrasound examination and computed tomography scan. After liver lobectomy, the diagnosis was confirmed on histopathology, the clinical signs resolved, and progesterone concentrations normalised. This report describes the presentation of a dog with progesterone‐secreting adrenocortical neoplasia and late metastasis.

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Progesterone: An Essential Diagnostic Resource in Veterinary Medicine

Tiberiu Constantin,

Petrișor Posastiuc,

Raluca Andrei

2024

Progesterone - Basic Concepts and Emerging New Applications

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Progesterone (P4), a steroid hormone, is widely recognized for its vital function in maintaining pregnancy across various animal species. Its functions extend beyond pregnancy management, encompassing the determination of pregnancy, optimal reproductive timing, anticipation of parturition, scheduling of elective cesarean sections, and identification of conditions like growth hormone disorders, insulin-dependent diabetes, and infertility. Its versatility extends to involvement in bone marrow trophication, stress response assessment, and neuroprotection following traumatic brain injuries or fetal hypoxia. Although the aforementioned are mostly directed toward females, it is important to note that progesterone is also used clinically in males. Monitoring blood progesterone levels in animals is essential in both healthy and pathological states, as emphasized in this chapter.

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Hyperprogesteronism associated with adrenocortical tumours in two dogs

Cited by 3 publications

References 28 publications

Progesterone-Related Diabetes Mellitus in the Bitch: Current Knowledge, the Role of Pyometra, and Relevance in Practice

Progesterone-Related Diabetes Mellitus in the Bitch: Current Knowledge, the Role of Pyometra, and Relevance in Practice

Subdiagnostic Cushing's syndrome in a Labrador retriever diagnosed with progesterone‐secreting adrenocortical neoplasia and late liver metastasis

Progesterone: An Essential Diagnostic Resource in Veterinary Medicine

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