Hyperpolarized xenon in NMR and MRI

Oros, A. M.; Shah, N. Jon

doi:10.1088/0031-9155/49/20/r01

Cited by 126 publications

(106 citation statements)

References 258 publications

(378 reference statements)

Supporting

Mentioning

102

Contrasting

Order By: Relevance

“…Radioactive 133 Xe is used as a tracer for measuring physiological blood flow (1) and also in detecting long-range fallout from nuclear weapons testing (2). Stable isotope 129 Xe has a spin-half nucleus that can be hyperpolarized to generate very large signals for MRI (3). Host molecules have been identified that bind xenon with high affinity (4), motivating further technological applications.…”

mentioning

confidence: 99%

Measurement of radon and xenon binding to a cryptophane molecular host

Jacobson

Khan²,

Collé³

et al. 2011

Proc. Natl. Acad. Sci. U.S.A.

View full text Add to dashboard Cite

Xenon and radon have many similar properties, a difference being that all 35 isotopes of radon ( 195 Rn– 229 Rn) are radioactive. Radon is a pervasive indoor air pollutant believed to cause significant incidence of lung cancer in many geographic regions, yet radon affinity for a discrete molecular species has never been determined. By comparison, the chemistry of xenon has been widely studied and applied in science and technology. Here, both noble gases were found to bind with exceptional affinity to tris-(triazole ethylamine) cryptophane, a previously unsynthesized water-soluble organic host molecule. The cryptophane–xenon association constant, K a = 42,000 ± 2,000 M -1 at 293 K, was determined by isothermal titration calorimetry. This value represents the highest measured xenon affinity for a host molecule. The partitioning of radon between air and aqueous cryptophane solutions of varying concentration was determined radiometrically to give the cryptophane–radon association constant K a = 49,000 ± 12,000 M -1 at 293 K.

show abstract

mentioning

confidence: 99%

Measurement of radon and xenon binding to a cryptophane molecular host

Jacobson

Khan²,

Collé³

et al. 2011

Proc. Natl. Acad. Sci. U.S.A.

View full text Add to dashboard Cite

show abstract

“…[82]). These results have been obtained by clinical research teams participating in the PHIL project (Polarized Helium to Image the Lung), a joint effort of nine European research teams in five countries [83].…”

Section: Current Status Of Researchmentioning

confidence: 99%

Magnetic Resonance Imaging: From Spin Physics to Medical Diagnosis

Nacher

2009

The Spin

View full text Add to dashboard Cite

Abstract. Two rather similar historical evolutions are evoked, each one originating in fundamental spin studies by physicists, and ending as magnetic resonance imaging (MRI), a set of invaluable tools for clinical diagnosis in the hands of medical doctors. The first one starts with the early work on nuclear magnetic resonance, the founding stone of the usual proton-based MRI, of which the basic principles are described. The second one starts with the optical pumping developments made to study the effects of spin polarization in various fundamental problems. Its unexpected outcome is a unique imaging modality, also based on MRI, for the study of lung physiology and pathologies.

show abstract

“…MRI provides exquisite anatomic images, with high spatial resolution (as good as tens of micrometers for preclinical studies and $1 mm for clinical studies) and excellent soft tissue contrast. Image contrast can often be selectively enhanced utilizing a range of passive contrast agents, some based on paramagnetic atoms, particularly gadolinium [1], some on superparamagnetic iron oxide particles [2], and others on hyperpolarized gases such as xenon [3]. MRI can interrogate aspects of physiology; for example, functional MRI (fMRI) takes advantage of the physiologic consequences of neuronal activation (the BBOLD[ effect) to visualize task-dependent responses [4].…”

Section: Introductionmentioning

confidence: 99%

The Integration of Positron Emission Tomography With Magnetic Resonance Imaging

Cherry¹,

Louie

Jacobs

2008

Proc. IEEE

View full text Add to dashboard Cite

| A number of laboratories and companies are currently exploring the development of integrated imaging systems for magnetic resonance imaging (MRI) and positron emission tomography (PET). Scanners for both preclinical and human research applications are being pursued. In contrast to the widely distributed and now quite mature PET/computed tomography technology, most PET/MRI designs allow for simultaneous rather than sequential acquisition of PET and MRI data. While this offers the possibility of novel imaging strategies, it also creates considerable challenges for acquiring artifact-free images from both modalities. This paper discusses the motivation for developing combined PET/MRI technology, outlines the obstacles in realizing such an integrated instrument, and presents recent progress in the development of both the instrumentation and of novel imaging agents for combined PET/MRI studies. The performance of the first-generation PET/MRI systems is described. Finally, a range of possible biomedical applications for PET/MRI are outlined.

show abstract

Hyperpolarized xenon in NMR and MRI

Cited by 126 publications

References 258 publications

Measurement of radon and xenon binding to a cryptophane molecular host

Measurement of radon and xenon binding to a cryptophane molecular host

Magnetic Resonance Imaging: From Spin Physics to Medical Diagnosis

The Integration of Positron Emission Tomography With Magnetic Resonance Imaging

Contact Info

Product

Resources

About