2022
DOI: 10.1089/ars.2021.0139
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Hyperpolarized 13C Magnetic Resonance Imaging as a Tool for Imaging Tissue Redox State, Oxidative Stress, Inflammation, and Cellular Metabolism

Abstract: Significance: Magnetic resonance imaging (MRI) with hyperpolarized 13 C-labelled redoxsensitive metabolic tracers can provide non-invasive functional imaging biomarkers reflecting; tissue redox state, oxidative stress, and inflammation, among others. The capability to use endogenous metabolites as 13 C-enriched imaging tracers without structural modification makes hyperpolarized 13 C MRI a promising tool to evaluate redox state in patients with various diseases. Recent Advances:Recent studies have demonstrated… Show more

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Cited by 5 publications
(6 citation statements)
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References 77 publications
(144 reference statements)
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“…21-0007). In ex vivo and in vivo experiments, HP [1-13 C]pyruvate solutions were prepared by using the smallest hydrogenation reaction chamber with inner volume of 19.4 cm 3 .…”
Section: B Ex Vivo and In Vivo Hp 13 C Mri Experimentsmentioning
confidence: 99%
See 1 more Smart Citation
“…21-0007). In ex vivo and in vivo experiments, HP [1-13 C]pyruvate solutions were prepared by using the smallest hydrogenation reaction chamber with inner volume of 19.4 cm 3 .…”
Section: B Ex Vivo and In Vivo Hp 13 C Mri Experimentsmentioning
confidence: 99%
“…YPERPOLARIZATION of heteronuclear spins such as 13 C and 15 N is a rapidly developing field of molecular imaging wherein nuclear magnetic resonance (NMR) and magnetic resonance imaging (MRI) signals can be transiently enhanced more than 10,000 times compared to that at thermal equilibrium level. This enhancement allows for the noninvasive and real-time monitoring of metabolic reactions of 13 C or 15 N labeled tracers in the body [1], [2], [3], [4]. Hyperpolarization-evoking methodologies can be roughly classified into three types: brute force, dynamic nuclear polarization (DNP), and parahydrogen-induced polarization (PHIP) [5].…”
Section: Introductionmentioning
confidence: 99%
“…In addition, multi-MRS is being used for cardiac studies, the use of 1 H, 13 C and 31 P provides a wealth of metabolic information for accurate diagnosis and treatment [ 54 ]. Hyperpolarized 13 C MRI has the potential to assess tissue redox status, oxidative stress, and inflammation and cellular metabolism [ 55 ]. It also examines the branching points of metabolic pathways to quantify the fate of metabolites in acute lung injury and inflammation [ 56 ].…”
Section: The Physical Phenomenon Of Magnetic Resonancementioning
confidence: 99%
“…All these prerequisites are met by NMR spectroscopy. In-cell NMR spectroscopy benets from compounded improvements in methodology and instrumentation, including hyperpolarized probe molecules, [5][6][7] improved hardware for enhancing nuclear spin polarization, 8 and cryogenically cooled detection electronics. 9 The objective for in-cell spectroscopy is usually different from metabolite characterization in metabolomics approaches on stable samples, whose pH value and temperature can be chosen for analysis.…”
Section: Introductionmentioning
confidence: 99%
“…All these prerequisites are met by NMR spectroscopy. In-cell NMR spectroscopy benefits from compounded improvements in methodology and instrumentation, including hyperpolarized probe molecules, 5–7 improved hardware for enhancing nuclear spin polarization, 8 and cryogenically cooled detection electronics. 9…”
Section: Introductionmentioning
confidence: 99%