Hyperpolarized <sup>129</sup>Xe NMR as an Alternative Approach for Investigating Structure and Transport in Ordered Mesoporous Materials Prepared via Pseudomorphic Transformation

Hollenbach, Julia; Küster, Christian; Uhlig, Hans; Wagner, Maximilian; Abel, Bernd; Gläser, Roger; Einicke, Wolf‐Dietrich; Enke, Dirk; Matysik, Jörg

doi:10.1021/acs.jpcc.7b04365

Cited by 5 publications

(3 citation statements)

References 47 publications

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“…Matysik and co‐workers tried to answer this question for the transformation of a silica gel, LiChrospher, which possesses a broad pore size distribution between 10 and 50 nm, to the well‐ordered MCM‐41 exhibiting hexagonally arranged pores with a very narrow pore size distribution of ≈4 nm. [ 99 ] They detected a 129 Xe signal with a chemical shift characteristic for the starting LiChrospher pore system throughout the reaction, until a conversion of ≈50% to MCM‐41 is reached. These observations support the domain model.…”

Section: Recent Applicationsmentioning

confidence: 99%

¹²⁹Xe NMR on Porous Materials: Basic Principles and Recent Applications

Wisser

Hartmann

2020

Adv Materials Inter

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A large number of functional and catalytic materials exhibit porosity, often on different length scales and with a hierarchical structure. The assessment of pore sizes, pore geometry, and pore interconnectivity is complex and usually not feasible by classical spectroscopic and diffraction techniques. One of the most powerful methods to probe these parameters is nuclear magnetic resonance (NMR) spectroscopy of xenon, which is introduced into the pore system. Adsorbed to the pore walls, it acts as probe nucleus. In this tutorial review, an introduction into the basic principles of 129Xe NMR spectroscopy and the models developed to determine pore sizes in different materials are given. The possibilities and limitations of this method for obtaining insights into hierarchical structures of functional materials are highlighted and a review of recent works is presented.

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Section: Recent Applicationsmentioning

confidence: 99%

¹²⁹Xe NMR on Porous Materials: Basic Principles and Recent Applications

Wisser

Hartmann

2020

Adv Materials Inter

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“…In addition to a variety of loaded drug molecules, the proposed approach shows promise for characterizing other nanocarriers featuring regular nanopores suitable for hosting 129 Xe atoms. For instance, the specific structures of MOFs − and ordered porous nanomaterials , can effectively modulate the microenvironments required for 129 Xe atoms hosting. Consequently, distinct MR signals can be generated for each individual nanocarrier.…”

Section: Discussionmentioning

confidence: 99%

Hyperpolarized ¹²⁹Xe Atoms Sense the Presence of Drug Molecules in Nanohosts Revealed by Magnetic Resonance Imaging

Zhang,

Yang,

Yuan

et al. 2024

Anal. Chem.

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Assessing the effectiveness of nanomedicines involves evaluating the drug content at the target site. Currently, most research focuses on monitoring the signal responses from loaded drugs, neglecting the changes caused by the nanohosts. Here, we propose a strategy to quantitatively evaluate the content of loaded drugs by detecting the signal variations resulting from the alterations in the microenvironment of the nanohosts. Specifically, hyperpolarized (HP) 129Xe atoms are employed as probes to sense the nanohosts’ environment and generate a specific magnetic resonance (MR) signal that indicates their accessibility. The introduction of drugs reduces the available space in the nanohosts, leading to a crowded microenvironment that hinders the access of the 129Xe atoms. By employing 129Xe atoms as a signal source to detect the alterations in the microenvironment, we constructed a three-dimensional (3D) map that indicated the concentration of the nanohosts and established a linear relationship to quantitatively measure the drug content within the nanohosts based on the corresponding MR signals. Using the developed strategy, we successfully quantified the uptake of the nanohosts and drugs in living cells through HP 129Xe MR imaging. Overall, the proposed HP 129Xe atom-sensing approach can be used to monitor alterations in the microenvironment of nanohosts induced by loaded drugs and provides a new perspective for the quantitative evaluation of drug presence in various nanomedicines.

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“…The degree of transformation can be controlled by the synthetic conditions, allowing the creation of materials with both the original and the newly formed porous structures, and the creation of complex hierarchical architectures with well-defined morphology. This process, called pseudomorphic synthesis, has been studied with HP 129 Xe NMR in the case of the transformation of LiChrospher 60 silica gel and controller pore glasses (CPG) into MCM-41 by analyzing materials with different degrees of transformation [104,105]. The authors were able to distinguish between two different transformation mechanisms for LiChrospher 60 and CPG, respectively.…”

Section: Mesoporous Silicamentioning

confidence: 99%

129Xe: A Wide-Ranging NMR Probe for Multiscale Structures

2022

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Porous materials are ubiquitous systems with a large variety of applications from catalysis to polymer science, from soil to life science, from separation to building materials. Many relevant systems of biological or synthetic origin exhibit a hierarchy, defined as spatial organization over several length scales. Their characterization is often elusive, since many techniques can only be employed to probe a single length scale, like the nanometric or the micrometric levels. Moreover, some multiscale systems lack tridimensional order, further reducing the possibilities of investigation. 129Xe nuclear magnetic resonance (NMR) provides a unique and comprehensive description of multiscale porous materials by exploiting the adsorption and diffusion of xenon atoms. NMR parameters like chemical shift, relaxation times, and diffusion coefficient allow the probing of structures from a few angstroms to microns at the same time. Xenon can evaluate the size and shape of a variety of accessible volumes such as pores, layers, and tunnels, and the chemical nature of their surface. The dynamic nature of the probe provides a simultaneous exploration of different scales, informing on complex features such as the relative accessibility of different populations of pores. In this review, the basic principles of this technique will be presented along with some selected applications, focusing on its ability to characterize multiscale materials.

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Hyperpolarized ¹²⁹Xe NMR as an Alternative Approach for Investigating Structure and Transport in Ordered Mesoporous Materials Prepared via Pseudomorphic Transformation

Cited by 5 publications

References 47 publications

¹²⁹Xe NMR on Porous Materials: Basic Principles and Recent Applications

¹²⁹Xe NMR on Porous Materials: Basic Principles and Recent Applications

Hyperpolarized ¹²⁹Xe Atoms Sense the Presence of Drug Molecules in Nanohosts Revealed by Magnetic Resonance Imaging

129Xe: A Wide-Ranging NMR Probe for Multiscale Structures

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Hyperpolarized 129Xe NMR as an Alternative Approach for Investigating Structure and Transport in Ordered Mesoporous Materials Prepared via Pseudomorphic Transformation

Cited by 5 publications

References 47 publications

129Xe NMR on Porous Materials: Basic Principles and Recent Applications

129Xe NMR on Porous Materials: Basic Principles and Recent Applications

Hyperpolarized 129Xe Atoms Sense the Presence of Drug Molecules in Nanohosts Revealed by Magnetic Resonance Imaging

129Xe: A Wide-Ranging NMR Probe for Multiscale Structures

Contact Info

Product

Resources

About

Hyperpolarized ¹²⁹Xe NMR as an Alternative Approach for Investigating Structure and Transport in Ordered Mesoporous Materials Prepared via Pseudomorphic Transformation

¹²⁹Xe NMR on Porous Materials: Basic Principles and Recent Applications

¹²⁹Xe NMR on Porous Materials: Basic Principles and Recent Applications

Hyperpolarized ¹²⁹Xe Atoms Sense the Presence of Drug Molecules in Nanohosts Revealed by Magnetic Resonance Imaging