Hyperpolarized 13C Magnetic Resonance Treatment Response Monitoring: A New Paradigm for Multiorgan Metabolic Assessment of Pharmacological Interventions?

Laustsen, Christoffer

doi:10.2337/dbi16-0055

Cited by 3 publications

(4 citation statements)

References 15 publications

(26 reference statements)

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“…Expression of the genes encoding regulatory enzymes PEPCK ( Pck1 ) and glucose-6-phosphatase ( G6pc) were both increased in kidney whereas only Pck1 expression was increased in heart, a non-gluconeogenic organ. Both of these sets of results suggested that hyperpolarized 13 C MR may be valuable in assessing systemic processes (exemplified by gluconeogenesis) in which various organs have distinct roles [ 117 ].…”

Section: Imaging Oxygen Consumption and Utilizationmentioning

confidence: 99%

“…The authors concluded that hyperpolarized 13 C-DHA enabled non-invasive assessment of redox capacity in diabetic renal injury and in response to treatment [ 78 ]. Oxidative stress is also the purported mechanism driving the CRS, and as such, progressive monitoring of the DHA/VitC ratio in models of primary and secondary CRS could provide important information regarding the interplay of the two organs [ 117 ].…”

Section: Imaging Oxygen Consumption and Utilizationmentioning

confidence: 99%

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Imaging oxygen metabolism with hyperpolarized magnetic resonance: a novel approach for the examination of cardiac and renal function

Schroeder

Laustsen

2017

Bioscience Reports

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Every tissue in the body critically depends on meeting its energetic demands with sufficient oxygen supply. Oxygen supply/demand imbalances underlie the diseases that inflict the greatest socio-economic burden globally. The purpose of this review is to examine how hyperpolarized contrast media, used in combination with MR data acquisition methods, may advance our ability to assess oxygen metabolism non-invasively and thus improve management of clinical disease. We first introduce the concept of hyperpolarization and how hyperpolarized contrast media have been practically implemented to achieve translational and clinical research. We will then analyse how incorporating hyperpolarized contrast media could enable realization of unmet technical needs in clinical practice. We will focus on imaging cardiac and renal oxygen metabolism, as both organs have unique physiological demands to satisfy their requirements for tissue oxygenation, their dysfunction plays a fundamental role in society’s most prevalent diseases, and each organ presents unique imaging challenges. It is our aim that this review attracts a multi-disciplinary audience and sparks collaborations that utilize an exciting, emergent technology to advance our ability to treat patients adversely affected by an oxygen supply/demand mismatch.

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Section: Imaging Oxygen Consumption and Utilizationmentioning

confidence: 99%

Section: Imaging Oxygen Consumption and Utilizationmentioning

confidence: 99%

Imaging oxygen metabolism with hyperpolarized magnetic resonance: a novel approach for the examination of cardiac and renal function

Schroeder

Laustsen

2017

Bioscience Reports

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“…The ability to alter metabolic substrate selection and to monitor the metabolic consequence of treatment in real time is believed to be crucial in personalized medicine. This is particularly true in patients with abnormal metabolic patterns which could significantly alter the treatment response . In the normal heart, energy is primarily (>95%) produced via oxidative metabolism of free fatty acids (FFAs) and glucose, with each energy source contributing to ATP production at 60–90% and 10–40%, respectively .…”

Section: Introductionmentioning

confidence: 99%

“…This is particularly true in patients with abnormal metabolic patterns which could significantly alter the treatment response. 10,11 In the normal heart, energy is primarily (>95%) Abbreviations used: ANOVA, analysis of variance; AUC, area under the curve; CINE-LVF, CINE left ventricular function; CSI, chemical shift image; ECG, electrocardiogram; EF, ejection fraction; ELISA, enzyme-linked immunosorbent assay; FA, flip angle; FFA, free fatty acid; FOV, field of view; GIK, glucose-insulinpotassium; ICC, interclass correlation coefficient; MR, magnetic resonance; MRI, magnetic resonance imaging; MRS, magnetic resonance spectroscopy; PET, positron emission tomography; RF, radiofrequency; ROI, region of interest produced via oxidative metabolism of free fatty acids (FFAs) and glucose, with each energy source contributing to ATP production at 60-90% and 10-40%, respectively. 12 These ratios vary widely under normal physiological conditions, e.g.…”

Section: Introductionmentioning

confidence: 99%

Imaging porcine cardiac substrate selection modulations by glucose, insulin and potassium intervention: A hyperpolarized [1‐¹³C]pyruvate study

et al. 2017

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Cardiac metabolism has received considerable attention in terms of both diagnostics and prognostics, as well as a novel target for treatment. As human trials involving hyperpolarized magnetic resonance in the heart are imminent, we sought to evaluate the general feasibility of detection of an imposed shift in metabolic substrate utilization during metabolic modulation with glucose-insulin-potassium (GIK) infusion, and thus the limitations associated with this strategy, in a large animal model resembling human physiology. Four [1- C]pyruvate injections did not alter the blood pressure or ejection fraction over 180 min. Hyperpolarized [1- C]pyruvate conversion showed a generally high reproducibility, with intraclass correlation coefficients between the baseline measurements at 0 and 30 min as follows: lactate to pyruvate, 0.85; alanine to pyruvate, 1.00; bicarbonate to pyruvate, 0.83. This study demonstrates that hyperpolarized [1- C]pyruvate imaging is a feasible technique for cardiac studies and shows a generally high reproducibility in fasted large animals. GIK infusion increases the metabolic conversion of pyruvate to its metabolic derivatives lactate, alanine and bicarbonate, but with increased variability.

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Comprehensive Literature Review of Hyperpolarized Carbon-13 MRI: The Road to Clinical Application

2021

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This review provides a comprehensive assessment of the development of hyperpolarized (HP) carbon-13 metabolic MRI from the early days to the present with a focus on clinical applications. The status and upcoming challenges of translating HP carbon-13 into clinical application are reviewed, along with the complexity, technical advancements, and future directions. The road to clinical application is discussed regarding clinical needs and technological advancements, highlighting the most recent successes of metabolic imaging with hyperpolarized carbon-13 MRI. Given the current state of hyperpolarized carbon-13 MRI, the conclusion of this review is that the workflow for hyperpolarized carbon-13 MRI is the limiting factor.

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Hyperpolarized 13C Magnetic Resonance Treatment Response Monitoring: A New Paradigm for Multiorgan Metabolic Assessment of Pharmacological Interventions?

Cited by 3 publications

References 15 publications

Imaging oxygen metabolism with hyperpolarized magnetic resonance: a novel approach for the examination of cardiac and renal function

Imaging oxygen metabolism with hyperpolarized magnetic resonance: a novel approach for the examination of cardiac and renal function

Imaging porcine cardiac substrate selection modulations by glucose, insulin and potassium intervention: A hyperpolarized [1‐¹³C]pyruvate study

Comprehensive Literature Review of Hyperpolarized Carbon-13 MRI: The Road to Clinical Application

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Hyperpolarized 13C Magnetic Resonance Treatment Response Monitoring: A New Paradigm for Multiorgan Metabolic Assessment of Pharmacological Interventions?

Cited by 3 publications

References 15 publications

Imaging oxygen metabolism with hyperpolarized magnetic resonance: a novel approach for the examination of cardiac and renal function

Imaging oxygen metabolism with hyperpolarized magnetic resonance: a novel approach for the examination of cardiac and renal function

Imaging porcine cardiac substrate selection modulations by glucose, insulin and potassium intervention: A hyperpolarized [1‐13C]pyruvate study

Comprehensive Literature Review of Hyperpolarized Carbon-13 MRI: The Road to Clinical Application

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Imaging porcine cardiac substrate selection modulations by glucose, insulin and potassium intervention: A hyperpolarized [1‐¹³C]pyruvate study