Hyperplastic tuberculosis of the stomach causing hour-glass deformity, with complete squamous metaplasia of the upper loculus

Watson, G. W.; Flint, E. R.; Stewart, Matthew

doi:10.1002/bjs.1800249413

Cited by 24 publications

(8 citation statements)

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“…Although the pathophysiology of squamous metaplasia in the stomach remains obscure, prolonged injury appears to be a prerequisite for this mucosal abnormality. The presence of squamous epithelium in the gastric mucosa has been described in patients with underlying diseases such as peptic ulcer [ 9 ], tuberculosis [ 10 ], syphilis [ 4 ], corrosive gastritis [ 3 ], pernicious anemia [ 11 ], and aberrant pancreatic tissue [ 12 ]. These cases support the hypothesized relationship between injurious stimuli and the development of squamous metaplasia.…”

Section: Discussionmentioning

confidence: 99%

Exuberant squamous metaplasia of the gastric mucosa in a patient with gastric adenocarcinoma

2015

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BackgroundThe presence of squamous epithelium in the stomach is only occasionally encountered and is associated with prolonged mucosal injury. Squamous metaplasia in patients with cancer is relatively rare and only four cases have been reported in the stomach, all of which have been associated with squamous cell carcinomas. We present the first case of exuberant squamous metaplasia in a patient with gastric adenocarcinoma of the cardia.Case presentationA 56-year-old woman presented with epigastric pain and weight loss. Endoscopy showed an irregular depressed hyperemic lesion covered with a whitish plaque on the cardia. A total gastrectomy was performed and the tumor in the subcardia was found to extend up to the proximal stomach with diffuse squamous metaplasia in the surface of the tumor and proximal gastric mucosa in contiguity with the esophageal squamous epithelium. It is believed that the squamous extension from the esophagus to the proximal stomach and the gastric adenocarcinoma occurred at the same time.ConclusionsSynchronous squamous metaplasia and underlying adenocarcinoma in the stomach is extremely rare. Recognition of this entity would be beneficial for clinicians to avoid unnecessary treatment.Virtual SlidesThe virtual slide(s) for this article can be found here: http://www.diagnosticpathology.diagnomx.eu/vs/1035146445160150.

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Section: Discussionmentioning

confidence: 99%

Exuberant squamous metaplasia of the gastric mucosa in a patient with gastric adenocarcinoma

2015

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“…It can occur during healing of inflammatory conditions,1 tuberculosis,2 or even with an aberrant pancreatic tissue 3. So far, only several cases have been reported referring the endoscopic findings of gastric squamous metaplasia 4,5.…”

Section: Introductionmentioning

confidence: 99%

A Case of Squamous Metaplasia of the Stomach

et al. 2013

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Intestinal metaplasia of the stomach is a common metaplastic lesion associated with chronic gastritis and mucosal atrophy. However, squamous metaplasia is a comparatively rare condition. On endoscopy, squamous metaplasia is usually observed as a whitish mucosal lesion in the lesser curvature of the cardiac region of the stomach. When Lugol's iodine solution is applied, the lesion stains brown in the same way as normal esophageal mucosa. We report a case of 79-year-old man with a whitish flat lesion in the lesser curvature of the cardiac region on surveillance endoscopy after endoscopic treatment of gastric adenoma. The endoscopic biopsy showed stratified squamous epithelial mucosa.

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“…It has been rarely described with other associated diseases, such as peptic ulcers [4] , tuberculosis [5] , syphilis [6] , corrosive gastritis [7] , extreme cachexia [8] , pernicious anemia [9] and aberrant pancreatic tissue [10] . It may coexist with neoplasms [11,12] .…”

Section: Introductionmentioning

confidence: 99%

A squamous metaplasia in a gastric ulcer scar of the antrum

Cho¹,

Kim²,

Ji³

et al. 2008

WJG

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An 81-year-old man presented with epigastric pain and weight loss for one month. He had a past history of pulmonary tuberculosis, 10 years ago. We performed a gastroscopy, which showed a linear depressed whitish gastric ulcer scar (0.8 cm in length) in the posterior wall of the prepyloric antrum. The result of biopsy was reported as squamous epithelium. Immunohistochemical staining using an antibody to high molecular weight cytokeratin (HMC) revealed positive staining in the squamous epithelium. Two years later, the lesion was followed up. The lesion remained at same site endoscopically, but no squamous epithelium could be seen microscopically.

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Hyperplastic tuberculosis of the stomach causing hour-glass deformity, with complete squamous metaplasia of the upper loculus

Cited by 24 publications

References 0 publications

Exuberant squamous metaplasia of the gastric mucosa in a patient with gastric adenocarcinoma

Exuberant squamous metaplasia of the gastric mucosa in a patient with gastric adenocarcinoma

A Case of Squamous Metaplasia of the Stomach

A squamous metaplasia in a gastric ulcer scar of the antrum

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