Hyperplastic Callus Formation in Osteogenesis Imperfecta

Burchardt, A.-J.; Wagner, A.; Basse, P

doi:10.1080/02841859409174329

Cited by 8 publications

(5 citation statements)

References 7 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…2 The patients have usually had many previous fractures. 3,4 The occurrence of hyperplastic callus may be an isolated event or there may be involvement of other bones at intervals of months or years.…”

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Bilateral total hip replacement in osteogenesis imperfecta with hyperplastic callus

Ramaswamy¹,

Kosashvili²,

Cameron³

2009

The Journal of Bone and Joint Surgery. British volume

View full text Add to dashboard Cite

Osteogenesis imperfecta is a rare inherited disorder of connective tissue which may present with recurrent fractures which are prone to nonunion and malunion resulting in deformity. Some patients develop osteoarthritis of the hip. Formation of hyperplastic callus after recurrent fractures may deform the shape of the femur and preclude the use of standard implants at joint replacement. Replacement can thus be technically demanding. We present a case of bilateral hip replacement in a patient with osteogenesis imperfecta and hyperplastic callus which was treated by the use of long femoral allografts and cemented femoral stems.

show abstract

Section: Discussionmentioning

confidence: 99%

“…[1][2][3][4][5] Sub-clinical fractures involving the joints and ligamentous laxity are two major causes of osteoarthritis in these patients. The anatomy of the pelvis, femur and acetabulum is grossly distorted.…”

Section: Discussionmentioning

confidence: 99%

Bilateral total hip replacement in osteogenesis imperfecta with hyperplastic callus

Ramaswamy¹,

Kosashvili²,

Cameron³

2009

The Journal of Bone and Joint Surgery. British volume

View full text Add to dashboard Cite

show abstract

“…Hyperplastic callus formation in OI was first described more than 90 years ago (6) . Although generally believed to be rare, (7) a number of case reports can be found in the literature (5,8–13) . The incidence of hyperplastic callus among OI patients is unknown, but in a series of 60 type IV patients, 10 (17%) had developed at least one hyperplastic callus before the age of 20 years (14) .…”

Section: Introductionmentioning

confidence: 99%

Type V Osteogenesis Imperfecta: A New Form of Brittle Bone Disease

Glorieux

Rauch

Plotkin

et al. 2000

Journal of Bone and Mineral Research

449

300

View full text Add to dashboard Cite

Osteogenesis imperfecta (OI) is commonly subdivided into four clinical types. Among these, OI type IV clearly represents a heterogeneous group of disorders. Here we describe 7 OI patients (3 girls), who would typically be classified as having OI type IV but who can be distinguished from other type IV patients. We propose to call this disease entity OI type V. These children had a history of moderate to severe increased fragility of long bones and vertebral bodies. Four patients had experienced at least one episode of hyperplastic callus formation. The family history was positive for OI in 3 patients, with an autosomal dominant pattern of inheritance. All type V patients had limitations in the range of pronation/supination in one or both forearms, associated with a radiologically apparent calcification of the interosseous membrane. Three patients had anterior dislocation of the radial head. A radiodense metaphyseal band immediately adjacent to the growth plate was a constant feature in growing patients. Lumbar spine bone mineral density was low and similar to age-matched patients with OI type IV. None of the type V patients presented blue sclerae or dentinogenesis imperfecta, but ligamentous laxity was similar to that in patients with OI type IV. Levels of biochemical markers of bone metabolism generally were within the reference range, but serum alkaline phosphatase and urinary collagen type I N-telopeptide excretion increased markedly during periods of active hyperplastic callus formation. Qualitative histology of iliac biopsy specimens showed that lamellae were arranged in an irregular fashion or had a meshlike appearance. Quantitative histomorphometry revealed decreased amounts of cortical and cancellous bone, like in OI type IV. However, in contrast to OI type IV, parameters that reflect remodeling activation on cancellous bone were mostly normal in OI type V, while parameters reflecting bone formation processes in individual remodeling sites were clearly decreased. Mutation screening of the coding regions and exon/intron boundaries of both collagen type I genes did not reveal any mutations affecting glycine codons or splice sites. In conclusion, OI type V is a new form of autosomal dominant OI, which does not appear to be associated with collagen type I mutations. The genetic defect underlying this disease remains to be elucidated. (J Bone Miner Res 2000;15:1650 -1658)

show abstract

“…Radiographs may be misleading in the early stage of hyperplastic callus formation because of spiculated ªsun-burstº radiations resembling osteosarcoma (Fig. 1) [1,5]. This phenomenon was observed by Strach [5] but fell into oblivion later.…”

Section: Discussionmentioning

confidence: 90%