Hyperpigmented Plaques of the Alar Crease: An Unusual Presentation of Acanthosis Nigricans

Abstract

Although acanthosis nigricans of the posterior neck and intertriginous areas is common, acanthosis nigricans of the supra-alar creases is rare. We present the case of an obese 16-year-old African American boy with hyperpigmented plaques along the supra-alar creases of his nose. Clinicians should be aware of this rare manifestation, because newly diagnosed acanthosis nigricans should prompt examination for insulin resistance.

The metabolic salute: A unique presentation of transverse nasal acanthosis nigricans and allergic rhinitis in an obese pediatric patient

“…While various pediatric nasal creases and lines have been reported, they have only recently been identified in the literature as uncommon presentations of AN . Furthermore, we did not find any previously reported association of transverse nasal AN with allergic saluting or allergic rhinitis in a pediatric patient during our review of the literature.…”

Acanthosis nigricans in obese adolescents: prevalence, impact, and management challenges

“…In contrast, the face, eyelids, supra-alar nasal creases, inner thigh, antecubital fossa, popliteal fossa, umbilicus, palms, soles, knuckles (Figure 5), nipples, and areolas are less frequently involved areas 25,28. The neck and axillae are frequently involved and are sites that are more socially acceptable than others for screening.…”

Lelis Syndrome: A Rare Cause of Acanthosis Nigricans

“…A rare cause of acanthosis nigricans that is often overlooked is Lelis syndrome (LS), a unique clinical syndrome characterized by ectodermal dysplasia and acanthosis nigricans . Some authors have suggested that LS occurs secondary to mutations in the EDA gene.…”