Hyperpigmentation induced by topical 5-aminolaevulinic acid plus visible light

Monfrecola, Giuseppe; Procaccini, Enrico Maria; D’Onofrio, Donatella; Roberti, G.; Liuzzi, Raffaele; Staibano, Stefania; Manco, A; Rosa, Gaetano De; Santoianni, P

doi:10.1016/s1011-1344(02)00384-6

Cited by 18 publications

(12 citation statements)

References 21 publications

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“…These results suggest that the effect of blue light appears to be manifested when melanin formation in melanocytes has been adequately activated by repeated UVB exposure, rather than in the initial stages when melanocytes have not yet been sufficiently activated. Although hyperpigmentation induced by photosensitizer plus visible light was reported (16), blue light only inhibited hyperpigmentation induced by UVB in this study. These results suggest that the amount of photoproduct produced by blue light was not enough to induce hyperpigmentation in guinea‐pig skin.…”

Section: Discussioncontrasting

confidence: 68%

Blue light inhibits melanin synthesis in B16 melanoma 4A5 cells and skin pigmentation induced by ultraviolet B in guinea‐pigs

Ohara

Kobayashi

Fujiwara

et al. 2004

Photoderm Photoimm Photomed

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Section: Discussioncontrasting

confidence: 68%

Blue light inhibits melanin synthesis in B16 melanoma 4A5 cells and skin pigmentation induced by ultraviolet B in guinea‐pigs

Ohara

Kobayashi

Fujiwara

et al. 2004

Photoderm Photoimm Photomed

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“…In contrast to the present study, a few studies demonstrated PDT‐induced hyperpigmentation in vivo (Juzeniene et al., ; Monfrecola et al., ). In addition, post‐inflammatory hyperpigmentation is one of the side effects of PDT in clinical practice.…”

Section: Discussioncontrasting

confidence: 99%

Photodynamic therapy inhibits melanogenesis through paracrine effects by keratinocytes and fibroblasts

Kim

Park

et al. 2017

Pigment Cell Melanoma Res

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Photodynamic therapy (PDT) is a treatment option for skin cancer and premalignant skin diseases and exhibits rejuvenation effects, including reducing fine wrinkles and whitening, on aged skin. In this study, we investigated the mechanism underlying the whitening effects of PDT on melanocytes (MCs) in vitro and in vivo. Exposure of MCs to PDT in vitro reduced their melanin content and tyrosinase activity without, however, affecting cell survival. Interestingly, melanogenesis was also inhibited by exposing MCs to conditioned media of PDT-treated keratinocytes or dermal fibroblasts. This paracrine effect was likely due to a decreased release of melanocyte-stimulating cytokines such as Kit ligand and hepatocyte growth factor from these cells. Furthermore, we observed that PDT reduced mottled hyperpigmentation of photoaged patient skin in vivo, highlighting the clinical importance of skin whitening by PDT.

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“…Postinflammatory hypopigmentation or hyperpigmentation can occur following PDT 1 . Studies on healthy skin showed that hyperpigmentation following PDT is dependent on ALA dose, occurs after 48–72 h and increases during the 2 weeks following treatment 26,210 . Hyperpigmentation of psoriatic lesions following PDT appears to be common.…”

Section: Adverse Effectsmentioning

confidence: 99%

“…1 Studies on healthy skin showed that hyperpigmentation following PDT is dependent on ALA dose, occurs after 48-72 h and increases during the 2 weeks following treatment. 26,210 Hyperpigmentation of psoriatic lesions following PDT appears to be common. Mild to moderate pigmentation was seen in all PDT-treated lesions in a study of 21 patients with psoriasis and in seven of eight patients in a further study.…”

Section: Chronicmentioning

confidence: 99%

Guidelines for topical photodynamic therapy: update

Morton

McKenna

Rhodes

et al. 2008

British Journal of Dermatology

431

385

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Summary Multicentre randomized controlled studies now demonstrate high efficacy of topical photodynamic therapy (PDT) for actinic keratoses, Bowen’s disease (BD) and superficial basal cell carcinoma (BCC), and efficacy in thin nodular BCC, while confirming the superiority of cosmetic outcome over standard therapies. Long‐term follow‐up studies are also now available, indicating that PDT has recurrence rates equivalent to other standard therapies in BD and superficial BCC, but with lower sustained efficacy than surgery in nodular BCC. In contrast, current evidence does not support the use of topical PDT for squamous cell carcinoma. PDT can reduce the number of new lesions developing in patients at high risk of skin cancer and may have a role as a preventive therapy. Case reports and small series attest to the potential of PDT in a wide range of inflammatory/infective dermatoses, although recent studies indicate insufficient evidence to support its use in psoriasis. There is an accumulating evidence base for the use of PDT in acne, while detailed study of an optimized protocol is still required. In addition to high‐quality treatment site cosmesis, several studies observe improvements in aspects of photoageing. Management of treatment‐related pain/discomfort is a challenge in a minority of patients, and the modality is otherwise well tolerated. Long‐term studies provide reassurance over the safety of repeated use of PDT.

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Hyperpigmentation induced by topical 5-aminolaevulinic acid plus visible light

Cited by 18 publications

References 21 publications

Blue light inhibits melanin synthesis in B16 melanoma 4A5 cells and skin pigmentation induced by ultraviolet B in guinea‐pigs

Blue light inhibits melanin synthesis in B16 melanoma 4A5 cells and skin pigmentation induced by ultraviolet B in guinea‐pigs

Photodynamic therapy inhibits melanogenesis through paracrine effects by keratinocytes and fibroblasts

Guidelines for topical photodynamic therapy: update

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